DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctr9 and ctr-9

DIOPT Version :9

Sequence 1:	NP_788448.1	Gene:	Ctr9 / 38149	FlyBaseID:	FBgn0035205	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	NP_001255000.1	Gene:	ctr-9 / 176335	WormBaseID:	WBGene00007184	Length:	1150	Species:	Caenorhabditis elegans

Alignment Length:	1162	Identity:	460/1162 - (39%)
Similarity:	675/1162 - (58%)	Gaps:	101/1162 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IEIPLQDT--DEVIEVDPDQLPDCPEVLSILKQERAPLHVWVNVALAYYKQKKTEDFVTLLEESR 67
            |.|||:|:  |||||::..:|||..|||.||:.|.|.|..|:.|||.||:|.:.:.|:.:| ||.
Worm    14 IAIPLKDSHEDEVIEINCSELPDGEEVLQILEAEEAKLSYWIEVALEYYRQDRVDLFMMIL-ESA 77

  Fly    68 SDDATKEYRDSDKDLMRALDMLAAHYVQEAYREKSKDKKRELFMKATNLYTSADKIIMYDQSHLL 132
            ...|..||....:|.|||||:|||:::.:.||||:||||.:.|.|||.|:.:||||.||:.|||.
Worm    78 GSRAGLEYEGVKQDQMRALDILAAYWMTQGYREKAKDKKSDFFSKATVLFNTADKIAMYEWSHLT 142

  Fly   133 GRAYFCLLEGD----KMDQADAQFNFVLNQSPSNIPSLLGKACIAFNRKDYRGAMAFYKKALRTN 193
            .||:|.|.|.|    |.:.||.|||:|:..:|.|:..|:|||.||||:|||:.|:.:::||:|..
Worm   143 VRAWFYLFERDKSTNKYELADQQFNYVVKTNPKNVLPLIGKAVIAFNKKDYKTAIYYFRKAIRQC 207

  Fly   194 PNCPANVRIGMAHCFLKMGNPEKAKLAFERALQLDQQCVGALIGLAVLKLNQLEPESNKLGVQML 258
            .:..|::|:|:.|||.|||..:|||.|||||::::...|.|:.||.::.||..:.:|.|..|.:.
Worm   208 RHTIADLRVGIGHCFAKMGMMDKAKTAFERAMEIEPYNVSAMCGLGIILLNTYDHDSLKHAVSLF 272

  Fly   259 SKAYTIDNANPMVLNHLANHFFFKKDYQKVHHLALHAFHNTENEAMRAESCYQLARSFHAQSDYD 323
            .::|.:...:|:.|.||||||||||:.::...||.||....:.::::||:.||:.|..|||..:|
Worm   273 GRSYNLQTDHPVALIHLANHFFFKKEIERAWTLAWHAATYNDCDSIKAEAFYQMGRCRHAQGQFD 337

  Fly   324 QAFQYYYQSTQIAPANFVLPHYGLGQMYIYRGDTENAAQCFEKVLKIQPGNYETMKILGSLYAH- 387
            .|::||||:.|.......|.|||||||||:|.:.|.|.:||:.|.|..|.|.:|||||||||||
Worm   338 GAYKYYYQARQANNGEHTLAHYGLGQMYIHRNEIEEAIKCFDTVHKRLPNNTDTMKILGSLYAHV 402

  Fly   388 -----SNSQTKRDMAKTHLKKVTEQFPEDIEAWIELAQILEQNDLQASLSAYGTASSILRDKAKY 447
                 :.:...|...:..|.|......:|.||.|:|||:||..|.:.||..|..|..:|......
Worm   403 QLNDPAQTAEARQKGRDVLGKYLAVENDDYEACIDLAQLLEATDPKRSLELYENAIDLLVTNESI 467

  Fly   448 EIPAEIQNNVASLHYRL-------GNLKMAKLTLESALKHATSE----MDKDVKYYESIQVTMKY 501
            :...|:.|||.:|:..:       .:.|.||..||..|.  |.|    :::.....:|..:|::|
Worm   468 QPQPEMLNNVGALYMSMKQYEKAEHHFKRAKERLEEQLN--TDEGSLLLERRSAPEKSHLLTIRY 530

  Fly   502 NLARLNEAMSSYDVADKLYKEILKEHPNYIDCYLRLGCMARDKGLIFVASDFFKDALNINNDNPD 566
            |||...|.:.....|:::||:|:||.|.|||.||||||:.||:..::.:|.:.|..:..:..:|.
Worm   531 NLALCLEHLCRTVEAEQMYKDIVKECPGYIDGYLRLGCITRDRHQVYESSLWLKQGVQFDQASPI 595

  Fly   567 ARSLLGNLHLAKMQFALGQKNFETIL------KNPSTSTDAYSLIALGNFSLQTLHQPSRDKEKE 625
            ..:|:||||.||.::...||.||.||      |.|    |.|||:||||...:.|..|||.||.|
Worm   596 VWTLIGNLHFAKNEWMPAQKKFEFILSKIFNNKIP----DPYSLVALGNVWFEQLLNPSRKKEDE 656

  Fly   626 RKHQEKALAIFKQVLRNDPRNIWATNGIGAVLAHKGCVIEARDIFAQVREATADFCDVWLNIAHV 690
            :|:.::||.::::.|:..|:|::|.||||.|||:|....:|||:|:||||:|::|.|||||||||
Worm   657 KKYIDRALQMYQKALKLQPKNMYAANGIGCVLAYKRNWNDARDVFSQVRESTSEFYDVWLNIAHV 721

  Fly   691 YVEQKQYISAIQMYENCMKKFYKHNNVEVMQYLARAYLRANKLVDAKAVLLKARRVAPQDTVLLF 755
            .:|::|:::|:|||.:.||||.|.|:..:..|||:||.|||.|.:||..|..|......:|.|.|
Worm   722 CMEREQWMAAVQMYSSAMKKFRKENDSTLQHYLAKAYYRANMLNEAKEALECAMLDQLDNTQLKF 786

  Fly   756 NIAVVLSRLAMAILKDEKSTLEIVLQAVHELELAQKYFQYLSVHGDKN------RFNIEVAGIEA 814
            |.|:||.:.|..:|:..|.|.|.|..|:.:|:.|.|.|||:|.:.|:.      |.:..:...||
Worm   787 NYAIVLKKSAKEVLRGHKMTSEQVTAAIDDLKFADKIFQYISKNDDRQSSHTGMRISRTICAEEA 851

  Fly   815 STCQDLLSQAQYHVGRARRIDEEERSLRRKQEEEREAFKIKVAEQRKRREEEAKTSRDQLLAKRQ 879
            ..|:|||:||::.:..|:..|||||.|..|||:|:.|.:.|:.|:.:.:||..|...:.:...|.
Worm   852 KNCKDLLTQAKHKLAAAQTQDEEERRLMEKQEKEKIALQNKMIEEARAKEEAEKQKLEDMKNLRL 916

  Fly   880 EYVEKTKNMLIIADAPPEKERKKGGGRGRK----DDYIS---------GTESDNDGARREGERPS 931
            .::|.||::|.:.:...|| |:.||||.|:    |::::         |.|...||.|||..:..
Worm   917 SFIEMTKDVLRLPEIVEEK-RRGGGGRKRRNDDGDEFVNDSSDAGNYDGEEGGEDGERRERRKKD 980

  Fly   932 KKKGKGERKKGGGRKRKTEKYESDSEEEPGASGKSGKKKGKKPKPVKESKEKLSAKQRLKVLSKE 996
            |...|..|||   |:|:      || ..|.::.:..||:.:|.:..::.:|||||||..|:.|:.
Worm   981 KAAKKASRKK---RERR------DS-GGPDSNRRDEKKRKRKEERDRKLQEKLSAKQSAKIKSRA 1035

  Fly   997 TISTSESESDGKRSKSRSRSRSRNRSGSR-------SGSASRSGSDREASRKRSRSR-------- 1046
            .:|:|||..|.|  ...:...|.:....|       |.:.:.|.||||.:.|:.:.:
Worm  1036 FLSSSESSDDDK--PKPAADSSDDEVDPRPPVDEFDSPTRTDSDSDRETTTKKKKKKAVVDSDEG 1098

  Fly  1047 --SGSGSGSD---------SDEATKRKRARNRIESGGES-DRSGSRARSKSSSRSRS 1091
              ||||||||         ||:....|.|      ||.| |..||.|..|....|.|
Worm  1099 SVSGSGSGSDNDDKPIIGGSDDDDDDKPA------GGNSRDSDGSDAPKKKVIESDS 1149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctr9	NP_788448.1	TPR repeat	130..157	CDD:276809	15/30 (50%)
		TPR_11	166..228	CDD:290150	32/61 (52%)
		TPR repeat	166..191	CDD:276809	14/24 (58%)
		TPR repeat	196..227	CDD:276809	17/30 (57%)
		TPR repeat	269..300	CDD:276809	16/30 (53%)
		TPR_11	305..372	CDD:290150	32/66 (48%)
		TPR repeat	306..334	CDD:276809	14/27 (52%)
		TPR repeat	340..370	CDD:276809	16/29 (55%)
		TPR_1	344..374	CDD:278916	17/29 (59%)
		TPR repeat	375..406	CDD:276809	14/36 (39%)
		NRDE-2	400..>532	CDD:285605	45/142 (32%)
		TPR repeat	412..437	CDD:276809	12/24 (50%)
		TPR repeat	501..525	CDD:276809	9/23 (39%)
		TPR repeat	530..560	CDD:276809	13/29 (45%)
		TPR repeat	565..593	CDD:276809	14/33 (42%)
		TPR repeat	646..676	CDD:276809	17/29 (59%)
		TPR repeat	681..709	CDD:276809	15/27 (56%)
		TPR_11	682..748	CDD:290150	34/65 (52%)
		TPR repeat	716..746	CDD:276809	13/29 (45%)
ctr-9	NP_001255000.1	TPR	156..442	CDD:223533	122/285 (43%)
		TPR repeat	180..205	CDD:276809	14/24 (58%)
		TPR repeat	211..241	CDD:276809	17/29 (59%)
		TPR repeat	283..311	CDD:276809	16/27 (59%)
		TPR repeat	320..348	CDD:276809	14/27 (52%)
		TPR repeat	354..384	CDD:276809	16/29 (55%)
		TPR_1	357..388	CDD:278916	17/30 (57%)
		TPR repeat	432..459	CDD:276809	13/26 (50%)
		TPR repeat	464..505	CDD:276809	10/40 (25%)
		TPR_12	473..554	CDD:290160	23/82 (28%)
		TPR repeat	510..554	CDD:276809	11/43 (26%)
		TPR repeat	559..589	CDD:276809	13/29 (45%)
		TPR repeat	594..618	CDD:276809	10/23 (43%)
		TPR_11	631..706	CDD:290150	36/74 (49%)
		TPR repeat	677..707	CDD:276809	17/29 (59%)
		TPR repeat	712..740	CDD:276809	15/27 (56%)
		TPR repeat	748..775	CDD:276809	12/26 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2457
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40668
Inparanoid	1	1.050	742	1.000	Inparanoid score	I300
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54530
OrthoDB	1	1.010	-	-		D396755at2759
OrthoFinder	1	1.000	-	-		FOG0003745
OrthoInspector	1	1.000	-	-		oto18469
orthoMCL	1	0.900	-	-		OOG6_102191
Panther	1	1.100	-	-	LDO	PTHR14027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1541
SonicParanoid	1	1.000	-	-		X4182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.010