DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rac1 and RhoBTB

DIOPT Version :9

Sequence 1:	NP_001261247.1	Gene:	Rac1 / 38146	FlyBaseID:	FBgn0010333	Length:	192	Species:	Drosophila melanogaster
Sequence 2:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster

Alignment Length:	203	Identity:	78/203 - (38%)
Similarity:	110/203 - (54%)	Gaps:	30/203 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QAIKCVVVGDGAVGKTCLLISYTTN------AFPGEYIPTVF--DNYS--ANVM------VDAKP 50
            :.:|||:|||.|||||.|:.:...|      .....::|||:  |.|.  .:|:      ||...
  Fly    12 ELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERSWEVVDGVN 76

  Fly    51 INLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVNPASFENVRAKWYPEVRHHCPSTPIILVGT 115
            ::|.||||.|  |:|:.|..:|.::||.|:|||:.:|.|..|.:..||||:|..||..|:||||.
  Fly    77 VSLRLWDTFG--DHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVPVILVGC 139

  Fly   116 KLDLR---DDKNTIEKLRDK--------KLAPITYPQGLAMAKEIGAVKYLECSALTQKGLKTVF 169
            |.|||   .|:|.:....:|        |...:...:..|:|||:| |.|.|.|..|..|:..||
  Fly   140 KNDLRYMYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELG-VAYYETSVFTYFGVNEVF 203

  Fly   170 DEAIRSVL 177
            :.||||.|
  Fly   204 ENAIRSAL 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rac1	NP_001261247.1	Rac1_like	3..176	CDD:206663	76/199 (38%)
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	76/200 (38%)
		RHO	16..211	CDD:197554	76/197 (39%)
		BTB	<392..446	CDD:295341
		BTB	481..575	CDD:279045
		BTB	485..582	CDD:197585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466335
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24072
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840