DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scf and RCN2

DIOPT Version :9

Sequence 1:	NP_477392.1	Gene:	scf / 38145	FlyBaseID:	FBgn0025682	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_001258766.1	Gene:	RCN2 / 5955	HGNCID:	9935	Length:	335	Species:	Homo sapiens

Alignment Length:	346	Identity:	115/346 - (33%)
Similarity:	193/346 - (55%)	Gaps:	41/346 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RTRIQMLLLVVALTAVISGASASSIPEELPHNPLEHDPLHPRHFDGGEHNAQFDHEAFLGPDES- 66
            ||....|||   |.|..:||..:   ||| |.||            ||..:.:|.||.||..|.
Human     6 RTAALGLLL---LCAAAAGAGKA---EEL-HYPL------------GERRSDYDREALLGVQEDV 51

  Fly    67 KKFDSLTPEESRRRLGVIVDRIDENKDGSVTLAELKNWIAYTQRRYIEEDVGRVWKQHNPDNNET 131
            .::..|..||.::||..|:.:||.:.||.:|.:||.:||..:.:.|..::..:.:.:::.::::|
Human    52 DEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVEYDKNSDDT 116

  Fly   132 ISWDSYMQTVY----GFMDDLSPDEKEQE----ENGVSYKS-----LLK-----RDRYRWSVADQ 178
            ::||.|...:|    .|.::.:.|:.|:|    |..:..|.     ||:     :|:.|:..|:|
Human   117 VTWDEYNIQMYDRVIDFDENTALDDAEEESFRKEFAICKKQSFCFWLLRFNLHLKDKKRFEKANQ 181

  Fly   179 DLDDNLTKDEFTAFLHPEDHPSMKGVVLRETITDLDKDHDGKISVDEYIGDMYRSTGAEDEEPEW 243
            |....|:.:||.||.|||:...|...|::|.:.:.||:.||.:|::|::|| ||.....:|:|||
Human   182 DSGPGLSLEEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGD-YRWDPTANEDPEW 245

  Fly   244 VANEREAFSTHRDLDKDGYLNEEEVKQWIAPHDFDHSEAEAKHLLFEADADHDDKLTKEEILDKY 308
            :..|::.|....|.|.||.|:.:|:..|:.|::...::.||.||:.|.|.:.|.||::||||:..
Human   246 ILVEKDRFVNDYDKDNDGRLDPQELLPWVVPNNQGIAQEEALHLIDEMDLNGDKKLSEEEILENP 310

  Fly   309 DVFVGSQATDFGEALARHDEF 329
            |:|:.|:|||:|..|  ||::
Human   311 DLFLTSEATDYGRQL--HDDY 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scf	NP_477392.1	EF-hand_7	170..227	CDD:290234	21/56 (38%)
		EFh	206..273	CDD:238008	24/66 (36%)
		EF-hand_7	248..308	CDD:290234	22/59 (37%)
		EFh	248..306	CDD:298682	21/57 (37%)
RCN2	NP_001258766.1	EFh_CREC_RCN2	29..314	CDD:320022	94/297 (32%)
		EF-hand motif	29..59	CDD:320022	12/41 (29%)
		EF-hand motif	65..94	CDD:320022	12/28 (43%)
		EF-hand motif	101..130	CDD:320022	5/28 (18%)
		EF-hand motif	171..200	CDD:320022	12/28 (43%)
		EF-hand motif	208..237	CDD:320022	12/29 (41%)
		EF-hand motif	249..278	CDD:320022	10/28 (36%)
		EF-hand motif	285..314	CDD:320022	14/28 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4223
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920