DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scf and RCN3

DIOPT Version :9

Sequence 1:	NP_477392.1	Gene:	scf / 38145	FlyBaseID:	FBgn0025682	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	XP_024307388.1	Gene:	RCN3 / 57333	HGNCID:	21145	Length:	365	Species:	Homo sapiens

Alignment Length:	376	Identity:	148/376 - (39%)
Similarity:	205/376 - (54%)	Gaps:	62/376 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARTRIQMLLLVVALTAVISGASASSIPEELPHN--------PLEHDPLHPRHFDGGEHNAQFDH 57
            |.|..:.:|||::.     .||.....|:..||.        ||...|     .|....|.|:||
Human     2 MWRPSVLLLLLLLR-----HGAQGKPSPDAGPHGQGRVHQAAPLSDAP-----HDDAHGNFQYDH 56

  Fly    58 EAFLGPDESKKFDSLTPEESRRRLGVIVDRIDE--NKDGSVTLAELKNWIAYTQRRYIEEDVGRV 120
            |||||.:.:|:||.||||||:.|||.||||:|.  :.||.|:||||:.|||:||:|:|.:.|...
Human    57 EAFLGREVAKEFDQLTPEESQARLGRIVDRMDRAGDGDGWVSLAELRAWIAHTQQRHIRDSVSAA 121

  Fly   121 WKQHNPDNNETISWDSYMQTVYGFMDDLSPDEKEQE-ENGVSYKSLLKRDRYRWSVADQDLDDNL 184
            |..::.|.:..:.|:......||   ..:|.|:..: |:..:||.:|.||..|:.|||||.|...
Human   122 WDTYDTDRDGRVGWEELRNATYG---HYAPGEEFHDVEDAETYKKMLARDERRFRVADQDGDSMA 183

  Fly   185 TKDEFTAFLHPEDHPSMKGVV-------------------------------------LRETITD 212
            |::|.|||||||:.|.|:.:|                                     |:||:.|
Human   184 TREELTAFLHPEEFPHMRDIVIALPGAKFPREPLTLTPGVQPPPGARVIGPQPQCPFLLQETLED 248

  Fly   213 LDKDHDGKISVDEYIGDMYRSTGAEDEEPEWVANEREAFSTHRDLDKDGYLNEEEVKQWIAPHDF 277
            ||::.||.:.|:|||.|:|.:...| |||.||..||:.|...|||:|||:|:..||..|:.|...
Human   249 LDRNKDGYVQVEEYIADLYSAEPGE-EEPAWVQTERQQFRDFRDLNKDGHLDGSEVGHWVLPPAQ 312

  Fly   278 DHSEAEAKHLLFEADADHDDKLTKEEILDKYDVFVGSQATDFGEALARHDE 328
            |....||.|||.|:|.|.|.:|:|.|||..:::|||||||::||.|.||.:
Human   313 DQPLVEANHLLHESDTDKDGRLSKAEILGNWNMFVGSQATNYGEDLTRHHD 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scf	NP_477392.1	EF-hand_7	170..227	CDD:290234	29/93 (31%)
		EFh	206..273	CDD:238008	33/66 (50%)
		EF-hand_7	248..308	CDD:290234	28/59 (47%)
		EFh	248..306	CDD:298682	27/57 (47%)
RCN3	XP_024307388.1	EFh_CREC_RCN3	44..348	CDD:320028	125/312 (40%)
		EF-hand motif	44..73	CDD:320028	15/33 (45%)
		EF-hand motif	79..110	CDD:320028	18/30 (60%)
		EF-hand motif	117..146	CDD:320028	6/31 (19%)
		EF-hand motif	167..196	CDD:320028	17/28 (61%)
		EF-hand motif	204..270	CDD:320028	15/65 (23%)
		EF-hand motif	282..311	CDD:320028	14/28 (50%)
		EF-hand motif	318..348	CDD:320028	15/29 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10751
eggNOG	1	0.900	-	-		E1_KOG4223
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	1	1.000	-	-		otm40495
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1088
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.780