DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scf and rcn2

DIOPT Version :9

Sequence 1:	NP_477392.1	Gene:	scf / 38145	FlyBaseID:	FBgn0025682	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_001025434.1	Gene:	rcn2 / 571340	ZFINID:	ZDB-GENE-050706-62	Length:	322	Species:	Danio rerio

Alignment Length:	327	Identity:	106/327 - (32%)
Similarity:	164/327 - (50%)	Gaps:	24/327 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RTRIQMLLLVVALTAVISGASASSIPEELPHNPLEHDPLHPRHFDGGEHNAQFDHEAFLGPDESK 67
            :.|...|||:|   |.:|||..:.......||          |    ||||    ..|||.::..
Zfish    18 KIRYTFLLLLV---AYVSGAVGNREDHVFKHN----------H----EHNA----NTFLGSEDKD 61

  Fly    68 KFDSLTPEESRRRLGVIVDRIDENKDGSVTLAELKNWIAYTQRRYIEEDVGRVWKQHNPDNNETI 132
            :...|:|.|.|:||..||.:||.|.|..:|..|:..||....|:|..:|....:.:.:.:|:..:
Zfish    62 EIQKLSPSEQRKRLVEIVKKIDTNSDKYLTPEEITVWIQRVYRKYALDDAEERFPEFDSNNDGLV 126

  Fly   133 SWDSYMQTVYGFMDDLSPDEKEQEENGVSYKSLLKRDRYRWSVADQDLDDNLTKDEFTAFLHPED 197
            |||.|...::|...::..|...::....|.:.|..:::.|:..|:.|....|...||.||.||.:
Zfish   127 SWDEYNMVMHGHTVEVDADAVLEDPEEESLRFLHAKEKRRFDFANMDGSAGLNLTEFLAFTHPSE 191

  Fly   198 HPSMKGVVLRETITDLDKDHDGKISVDEYIGDMYRSTGAEDEEPEWVANEREAFSTHRDLDKDGY 262
            ...|....:.:.:::.|.|.||.||:.|:|||:  .|..:||..:|...|...|....|.|:||.
Zfish   192 VDHMTDFAIEDVLSEYDLDKDGFISLSEFIGDL--RTNEQDEPSQWEIEETVRFKDLYDQDQDGK 254

  Fly   263 LNEEEVKQWIAPHDFDHSEAEAKHLLFEADADHDDKLTKEEILDKYDVFVGSQATDFGEAL-ARH 326
            ||.:|..:|:||:.:..:..||.||:.|.|.|.|::|::.|||...|.|:.|:.||:|..| ..|
Zfish   255 LNRDEQLRWVAPNSYGSAREEALHLIKEMDQDGDNRLSETEILKNQDTFMHSEVTDYGRQLHVPH 319

  Fly   327 DE 328
            ||
Zfish   320 DE 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scf	NP_477392.1	EF-hand_7	170..227	CDD:290234	18/56 (32%)
		EFh	206..273	CDD:238008	24/66 (36%)
		EF-hand_7	248..308	CDD:290234	23/59 (39%)
		EFh	248..306	CDD:298682	22/57 (39%)
rcn2	NP_001025434.1	EFh	74..136	CDD:298682	20/61 (33%)
		EF-hand_7	75..131	CDD:290234	18/55 (33%)
		EF-hand_7	164..221	CDD:290234	18/56 (32%)
		EFh	165..221	CDD:298682	18/55 (33%)
		EFh	200..265	CDD:238008	24/66 (36%)
		EF-hand_7	200..259	CDD:290234	22/60 (37%)
		EF-hand_7	245..298	CDD:290234	21/52 (40%)
		EFh	245..298	CDD:298682	21/52 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4223
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920