DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scf and Rcn3

DIOPT Version :9

Sequence 1:	NP_477392.1	Gene:	scf / 38145	FlyBaseID:	FBgn0025682	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_001008694.1	Gene:	Rcn3 / 494125	RGDID:	1359365	Length:	328	Species:	Rattus norvegicus

Alignment Length:	334	Identity:	148/334 - (44%)
Similarity:	205/334 - (61%)	Gaps:	15/334 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARTRIQMLLLVVALTAVISGASASSIPEELPH--NPLEH-DPLHPRHFDGGEHNAQFDHEAFLG 62
            |.|..:.:|||::...|:     ....|:..||  :.:.| .||.....|....|.|:|||||||
  Rat     2 MWRWTLMLLLLLLRHWAL-----GKPSPDAGPHGQDRVHHGTPLSEAPHDDAHGNFQYDHEAFLG 61

  Fly    63 PDESKKFDSLTPEESRRRLGVIVDRID--ENKDGSVTLAELKNWIAYTQRRYIEEDVGRVWKQHN 125
            .|.:|:||.||||||:.|||.||||:|  .:.||.|:||||:.|||:||:|:|.:.|...|..::
  Rat    62 RDVAKEFDQLTPEESQARLGRIVDRMDLAGDSDGWVSLAELRAWIAHTQQRHIRDSVSAAWHTYD 126

  Fly   126 PDNNETISWDSYMQTVYGFMDDLSPDEKEQE-ENGVSYKSLLKRDRYRWSVADQDLDDNLTKDEF 189
            .|.:..:.|:......||..:   |.|:..: |:..:||.:|.||..|:.|||||.|...|::|.
  Rat   127 TDRDGRVGWEELRNATYGHYE---PGEEFHDVEDAETYKKMLARDERRFRVADQDGDSMATREEL 188

  Fly   190 TAFLHPEDHPSMKGVVLRETITDLDKDHDGKISVDEYIGDMYRSTGAEDEEPEWVANEREAFSTH 254
            |||||||:.|.|:.:|:.||:.||||:.||.:.|:|||.|:|.:...| |||.||..||:.|...
  Rat   189 TAFLHPEEFPHMRDIVVAETLEDLDKNKDGYVQVEEYIADLYSAEPGE-EEPAWVQTERQQFRDF 252

  Fly   255 RDLDKDGYLNEEEVKQWIAPHDFDHSEAEAKHLLFEADADHDDKLTKEEILDKYDVFVGSQATDF 319
            |||:|||.|:..||..|:.|...|....||.|||.|:|.|.|.:|:|.|||..:::|||||||::
  Rat   253 RDLNKDGRLDGSEVGYWVLPPSQDQPLVEANHLLHESDTDKDGRLSKAEILSNWNMFVGSQATNY 317

  Fly   320 GEALARHDE 328
            ||.|.||.:
  Rat   318 GEDLTRHHD 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scf	NP_477392.1	EF-hand_7	170..227	CDD:290234	29/56 (52%)
		EFh	206..273	CDD:238008	33/66 (50%)
		EF-hand_7	248..308	CDD:290234	28/59 (47%)
		EFh	248..306	CDD:298682	27/57 (47%)
Rcn3	NP_001008694.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..48		7/23 (30%)
		EFh_CREC_RCN3	44..311	CDD:320028	125/270 (46%)
		EF-hand motif	44..73	CDD:320028	15/28 (54%)
		EF-hand motif	79..110	CDD:320028	18/30 (60%)
		EF-hand motif	117..146	CDD:320028	6/28 (21%)
		EF-hand motif	167..196	CDD:320028	17/28 (61%)
		EF-hand motif	204..233	CDD:320028	15/28 (54%)
		EF-hand motif	245..274	CDD:320028	14/28 (50%)
		EF-hand motif	281..311	CDD:320028	15/29 (52%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	325..328		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340817
Domainoid	1	1.000	59	1.000	Domainoid score	I10385
eggNOG	1	0.900	-	-		E1_KOG4223
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	1	1.000	-	-		otm44637
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1088
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.710