DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scf and rcn3

DIOPT Version :9

Sequence 1:	NP_477392.1	Gene:	scf / 38145	FlyBaseID:	FBgn0025682	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_001002158.1	Gene:	rcn3 / 415248	ZFINID:	ZDB-GENE-040625-175	Length:	316	Species:	Danio rerio

Alignment Length:	324	Identity:	155/324 - (47%)
Similarity:	217/324 - (66%)	Gaps:	12/324 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MLLLVVALTAVISGASASSIP--EELPHNPLEHDPLHPRHFDGGEHNAQFDHEAFLGPDESKKFD 70
            |.||.:...|:.:|.|. ::|  |:..|:.|:...    |.....|..|||||||||.:|||.||
Zfish     1 MQLLFLGTLALFAGLSV-AVPAQEKRIHHKLDLSD----HAHDDAHGFQFDHEAFLGKEESKTFD 60

  Fly    71 SLTPEESRRRLGVIVDRIDENKDGSVTLAELKNWIAYTQRRYIEEDVGRVWKQHNPDNNETISWD 135
            .|:||||:.|||.|||:||.:|||.|:.|||.:||.:.|||||||:|.:.|.:::.:.:..|.|.
Zfish    61 QLSPEESKDRLGKIVDKIDTDKDGFVSHAELHHWIKHRQRRYIEENVDKHWNEYDQNKDGKIGWI 125

  Fly   136 SYMQTVYGFMDDLSPDEKEQEENGVSYKSLLKRDRYRWSVADQDLDDNLTKDEFTAFLHPEDHPS 200
            .|..|.||:..|...|:.:.:   .:|||:|.||..|:..||:|.|...|::|||||||||:...
Zfish   126 EYKNTTYGYYIDTEFDDVDDK---ATYKSMLNRDERRFKSADRDGDGVATREEFTAFLHPEEFDF 187

  Fly   201 MKGVVLRETITDLDKDHDGKISVDEYIGDMYRSTGAEDEEPEWVANEREAFSTHRDLDKDGYLNE 265
            |:.:|::|||.|:||:.||||.:.|||||||.....| .||:||..|::.||..||::|||:|:.
Zfish   188 MRDIVIQETIEDIDKNGDGKIDLQEYIGDMYNPEDGE-TEPDWVTTEKKQFSEFRDMNKDGFLDA 251

  Fly   266 EEVKQWIAPHDFDHSEAEAKHLLFEADADHDDKLTKEEILDKYDVFVGSQATDFGEALA-RHDE 328
            .||..||.|.:.||::.||:||:.|.|.|:|||:||:|||:.:::|||||||::||.|. ||||
Zfish   252 TEVSHWILPTEVDHADNEARHLIHETDKDNDDKITKKEILENWNMFVGSQATNYGEDLTKRHDE 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scf	NP_477392.1	EF-hand_7	170..227	CDD:290234	28/56 (50%)
		EFh	206..273	CDD:238008	34/66 (52%)
		EF-hand_7	248..308	CDD:290234	30/59 (51%)
		EFh	248..306	CDD:298682	29/57 (51%)
rcn3	NP_001002158.1	EF-hand_7	71..128	CDD:290234	27/56 (48%)
		EFh	73..122	CDD:298682	23/48 (48%)
		EF-hand_7	157..214	CDD:290234	28/56 (50%)
		EFh	157..214	CDD:238008	28/56 (50%)
		EFh	193..258	CDD:298682	33/65 (51%)
		EFh	234..292	CDD:298682	29/57 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580660
Domainoid	1	1.000	59	1.000	Domainoid score	I10640
eggNOG	1	0.900	-	-		E1_KOG4223
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2449
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	1	1.000	-	-		otm26091
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1088
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.760