DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scf and calu

DIOPT Version :9

Sequence 1:	NP_477392.1	Gene:	scf / 38145	FlyBaseID:	FBgn0025682	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_998840.1	Gene:	calu / 407965	XenbaseID:	XB-GENE-1007422	Length:	315	Species:	Xenopus tropicalis

Alignment Length:	327	Identity:	162/327 - (49%)
Similarity:	218/327 - (66%)	Gaps:	15/327 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TRIQMLLLVVALTAVISGASASSIPEELPHNPLEHDPLHPRHFDGGEHNAQFDHEAFLGPDESKK 68
            ||..:|.|.:.:..|:|.      |.| ..:.:.|||...........|..:||:||||.:|:|.
Frog     3 TRRLLLCLCLWVACVVSK------PTE-KKDRVHHDPQLSEKVHDDAQNFDYDHDAFLGAEEAKT 60

  Fly    69 FDSLTPEESRRRLGVIVDRIDENKDGSVTLAELKNWIAYTQRRYIEEDVGRVWKQHNPDNNETIS 133
            ||.||||||:.|||.||.:||.:|||.||:.||::||.:.|:|:|.|||.|.||.|:.:.:..:|
Frog    61 FDQLTPEESKERLGRIVGKIDADKDGYVTVNELRDWIIFAQKRWIYEDVERQWKGHDLNGDSMVS 125

  Fly   134 WDSYMQTVYGF-MDDLSPDEKEQEENGVSYKSLLKRDRYRWSVADQDLDDNLTKDEFTAFLHPED 197
            |:.|....||: :||..||      |..:||.::.||..|:.:||||.|...||:|||||||||:
Frog   126 WEEYKNATYGYILDDPDPD------NSFNYKQMMVRDERRFKMADQDGDLIATKEEFTAFLHPEE 184

  Fly   198 HPSMKGVVLRETITDLDKDHDGKISVDEYIGDMYRSTGAEDEEPEWVANEREAFSTHRDLDKDGY 262
            ...||.:|:.||:.|:||:.||.|.::|||||||...| :..|||||..|||.|...||.:.||.
Frog   185 FDYMKDIVVLETMEDIDKNGDGLIDLEEYIGDMYNHDG-DANEPEWVKTEREQFVEFRDKNHDGK 248

  Fly   263 LNEEEVKQWIAPHDFDHSEAEAKHLLFEADADHDDKLTKEEILDKYDVFVGSQATDFGEALARHD 327
            :::||.|.||.|.|:||:|||::||::|:|.:.|.|||:|||:||||:|||||||||||||.|||
Frog   249 MDKEETKDWILPSDYDHAEAESRHLVYESDQNKDSKLTREEIVDKYDLFVGSQATDFGEALVRHD 313

  Fly   328 EF 329
            ||
Frog   314 EF 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scf	NP_477392.1	EF-hand_7	170..227	CDD:290234	29/56 (52%)
		EFh	206..273	CDD:238008	33/66 (50%)
		EF-hand_7	248..308	CDD:290234	31/59 (53%)
		EFh	248..306	CDD:298682	30/57 (53%)
calu	NP_998840.1	EFh_CREC_Calumenin	37..299	CDD:320026	134/268 (50%)
		EF-hand motif	37..66	CDD:320026	12/28 (43%)
		EF-hand motif	72..101	CDD:320026	16/28 (57%)
		EF-hand motif	108..137	CDD:320026	11/28 (39%)
		EF-hand motif	155..184	CDD:320026	18/28 (64%)
		EF-hand motif	192..221	CDD:320026	16/28 (57%)
		EF-hand motif	233..262	CDD:320026	14/28 (50%)
		EF-hand motif	269..299	CDD:320026	17/29 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4781
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H936
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2588
OMA	1	1.010	-	-		QHG48619
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	1	1.000	-	-		otm47679
Panther	1	1.100	-	-	LDO	PTHR10827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3115
SonicParanoid	1	1.000	-	-		X1088
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110