DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scf and rcn3

DIOPT Version :9

Sequence 1:	NP_477392.1	Gene:	scf / 38145	FlyBaseID:	FBgn0025682	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_989389.1	Gene:	rcn3 / 395023	XenbaseID:	XB-GENE-5781886	Length:	323	Species:	Xenopus tropicalis

Alignment Length:	337	Identity:	146/337 - (43%)
Similarity:	214/337 - (63%)	Gaps:	30/337 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IQMLLLVVALTAVISGASASSIPEELPH----NPLEHDPLHPRHFDGGEHNAQFDHEAFLGPDES 66
            :.:.|||....:.:.|.......:.:.|    :..|||         .:...|:|||||||.:|:
Frog     4 LPVFLLVTLCVSWVMGVPTKEKKDRVHHSKDLSDHEHD---------DQKGFQYDHEAFLGKEEA 59

  Fly    67 KKFDSLTPEESRRRLGVIVDRIDENKDGSVTLAELKNWIAYTQRRYIEEDVGRVWKQHNPDNNET 131
            :.||.||||||:.|||.|:|::|::.|..:|..||..||.:..||:..||..:..|:::.:.:..
Frog    60 RTFDQLTPEESQHRLGKIIDQMDKDNDKYITSGELFAWIKHVSRRWNLEDSEKQGKKYDTNKDGM 124

  Fly   132 ISWDSYMQTVYGFM-------DDLSPDEKEQEENGVSYKSLLKRDRYRWSVADQDLDDNLTKDEF 189
            ||||.|.:.|||.:       .|::..:||:      |:.::.||..|:.|||:|.|...|::||
Frog   125 ISWDEYAKGVYGHLLGKGEEFYDVADKDKER------YRKMMMRDERRFKVADKDGDLIATREEF 183

  Fly   190 TAFLHPEDHPSMKGVVLRETITDLDKDHDGKISVDEYIGDMYRSTGAEDE-EPEWVANEREAFST 253
            |||||||::..|:.:|:.|||.|:||:.||.:.|.|||.|||  |..||| ||:||..||:.|:.
Frog   184 TAFLHPEEYGYMQDIVITETIEDIDKNDDGIVDVHEYIADMY--TPNEDEPEPDWVKTERQQFTD 246

  Fly   254 HRDLDKDGYLNEEEVKQWIAPHDFDHSEAEAKHLLFEADADHDDKLTKEEILDKYDVFVGSQATD 318
            .||::|||.::..|:.|||.|||:||::.|||||::|:|.|.|.||||:||||.:::|||||||:
Frog   247 FRDINKDGKMDRTEISQWILPHDYDHADLEAKHLVYESDKDKDGKLTKKEILDNWNMFVGSQATN 311

  Fly   319 FGEALA-RHDEF 329
            :||.|. |||||
Frog   312 YGEDLTRRHDEF 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scf	NP_477392.1	EF-hand_7	170..227	CDD:290234	28/56 (50%)
		EFh	206..273	CDD:238008	34/67 (51%)
		EF-hand_7	248..308	CDD:290234	33/59 (56%)
		EFh	248..306	CDD:298682	31/57 (54%)
rcn3	NP_989389.1	EFh_CREC_Calumenin_like	38..306	CDD:320024	127/284 (45%)
		EF-hand motif	38..67	CDD:320024	15/37 (41%)
		EF-hand motif	73..102	CDD:320024	12/28 (43%)
		EF-hand motif	109..138	CDD:320024	10/28 (36%)
		EF-hand motif	162..191	CDD:320024	17/28 (61%)
		EF-hand motif	199..228	CDD:320024	17/30 (57%)
		EF-hand motif	240..269	CDD:320024	13/28 (46%)
		EF-hand motif	276..306	CDD:320024	18/29 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10954
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2588
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	1	1.000	-	-		otm47679
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1088
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060