DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scf and Calu

DIOPT Version :9

Sequence 1:	NP_477392.1	Gene:	scf / 38145	FlyBaseID:	FBgn0025682	Length:	329	Species:	Drosophila melanogaster
Sequence 2:	NP_031620.1	Gene:	Calu / 12321	MGIID:	1097158	Length:	315	Species:	Mus musculus

Alignment Length:	325	Identity:	160/325 - (49%)
Similarity:	222/325 - (68%)	Gaps:	13/325 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IQMLLLVVALTAVISGASASSIPEELPHNPLEHDPLHPRHFDGGEHNAQFDHEAFLGPDESKKFD 70
            ::..|:.::|....:.:..:...:.:.|.|...|.:|     ....|..:||:||||.:|:|.||
Mouse     3 LRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVH-----NDAQNFDYDHDAFLGAEEAKSFD 62

  Fly    71 SLTPEESRRRLGVIVDRIDENKDGSVTLAELKNWIAYTQRRYIEEDVGRVWKQHNPDNNETISWD 135
            .||||||:.|||.||.:||::|||.||:.|||.||.:.|:|:|.|||.|.||.|:.:.:..:||:
Mouse    63 QLTPEESKERLGKIVSKIDDDKDGFVTVDELKGWIKFAQKRWIHEDVERQWKGHDLNEDGLVSWE 127

  Fly   136 SYMQTVYGF-MDDLSPDEKEQEENGVSYKSLLKRDRYRWSVADQDLDDNLTKDEFTAFLHPEDHP 199
            .|....||: :||..||:      |.:||.::.||..|:.:||:|.|...||:|||||||||::.
Mouse   128 EYKNATYGYVLDDPDPDD------GFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYD 186

  Fly   200 SMKGVVLRETITDLDKDHDGKISVDEYIGDMYRSTGAEDEEPEWVANEREAFSTHRDLDKDGYLN 264
            .||.:|::||:.|:||:.||.|.::|||||||...|..| |||||..|||.|...||.::||.::
Mouse   187 YMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNAD-EPEWVKTEREQFVEFRDKNRDGKMD 250

  Fly   265 EEEVKQWIAPHDFDHSEAEAKHLLFEADADHDDKLTKEEILDKYDVFVGSQATDFGEALARHDEF 329
            :||.|.||.|.|:||:||||:||::|:|.:.|.|||||||:||||:|||||||||||||.|||||
Mouse   251 KEETKDWILPSDYDHAEAEARHLVYESDQNKDGKLTKEEIVDKYDLFVGSQATDFGEALVRHDEF 315

Fly 330 329
Mouse 316 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scf	NP_477392.1	EF-hand_7	170..227	CDD:290234	28/56 (50%)
		EFh	206..273	CDD:238008	34/66 (52%)
		EF-hand_7	248..308	CDD:290234	33/59 (56%)
		EFh	248..306	CDD:298682	32/57 (56%)
Calu	NP_031620.1	EFh_CREC_Calumenin	37..299	CDD:320026	138/273 (51%)
		EF-hand motif	37..66	CDD:320026	13/33 (39%)
		EF-hand motif	72..101	CDD:320026	17/28 (61%)
		EF-hand motif	108..137	CDD:320026	11/28 (39%)
		EF-hand motif	155..184	CDD:320026	17/28 (61%)
		EF-hand motif	192..221	CDD:320026	16/28 (57%)
		EF-hand motif	233..262	CDD:320026	14/28 (50%)
		EF-hand motif	269..299	CDD:320026	19/29 (66%)
		Prevents secretion from ER	312..315		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7309
eggNOG	1	0.900	-	-		E1_KOG4223
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H936
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2448
Isobase	1	0.950	-	0	Normalized mean entropy	S2984
OMA	1	1.010	-	-		QHG48619
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	1	1.000	-	-		otm42569
orthoMCL	1	0.900	-	-		OOG6_105526
Panther	1	1.100	-	-	LDO	PTHR10827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3115
SonicParanoid	1	1.000	-	-		X1088
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820