DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rabex-5 and ANKRD27

DIOPT Version :9

Sequence 1:	NP_612093.1	Gene:	Rabex-5 / 38144	FlyBaseID:	FBgn0262937	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_115515.2	Gene:	ANKRD27 / 84079	HGNCID:	25310	Length:	1050	Species:	Homo sapiens

Alignment Length:	699	Identity:	144/699 - (20%)
Similarity:	236/699 - (33%)	Gaps:	199/699 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 LRIPDDGKRKLKLEIQRLDSDIRKY---MNGNGGKNINELSDLVQNAYTKVSDIVHNDPSFEIAT 203
            |:..:|.:..|....:|.|.:|..:   ......|::....|.....|||....:..|...::..
Human   135 LKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANALYTKCLQQLLRDSHLKMLA 199

  Fly   204 NEDRDSAIDFFEKVVMTQNHKFLFSPYF----TTDEDSDVKVQKRIRQLSWITAKHLDCSIDEVN 264
            .:  ::.::..::.|....|..:::..|    |.:...|....|..|.|..:..|.:.     |.
Human   200 KQ--EAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIG-----VK 257

  Fly   265 SEARDLVYNAISELVGIDSYYSPQEKLQCTWRCCRHIFELLKRATGGPAS--------ADDFLPA 321
            .|....:..|..||..::...|||:||.    |.|.:.:|:   |..|:.        |||.|..
Human   258 PEFSFNIPRAKRELAQLNKCTSPQQKLV----CLRKVVQLI---TQSPSQRVNLETMCADDLLSV 315

  Fly   322 LIFVVLKANPVRLHSNINFVTRFTNASRLMSGESGYYFTNLCSAIAFIENLNGESLGVSSEEFE- 385
            |:::::|.......:|::::..| ..|.|...|.||..|:..:||.:|..   .||.....|.|
Human   316 LLYLLVKTEIPNWMANLSYIKNF-RFSSLAKDELGYCLTSFEAAIEYIRQ---GSLSAKPPESEG 376

  Fly   386 -----------ALMSGQQPYSTPWESALLACESLHLISENMKRMEMLQKRNALISSGITSFEKEL 439
                       :|:|  |..|:|.:     |...|:.|.|.|.:|.|..:.        ..:|:.
Human   377 FGDRLFLKQRMSLLS--QMTSSPTD-----CLFKHIASGNQKEVERLLSQE--------DHDKDT 426

  Fly   440 I-----------DFQREVTERVD--TVI--------AKAPLNLLPIKTPAFLI------------ 471
            :           |.::.|:.|::  :|:        ...||::..:...|.||
Human   427 VQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNA 491

  Fly   472 ----GQARAHLLNESEAG---------HYQANM----------LH-------------------- 493
                |....||  ..:.|         ||:|:.          ||
Human   492 TDYHGATPLHL--ACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVE 554

  Fly   494 ------GGSLTSQSLTAAG-----GLVKPA---AASKESGLSLKDT-----------SMSSMGRL 533
                  |.......|..|.     |:::..   .||.|....||:|           |:.....|
Human   555 SCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHL 619

  Fly   534 S----------PLQQNVQPADHLF-ASPIFNYTAFDAVSLLEEPVPDANTDVLMLGSEFQGGLTN 587
            |          |:|...:..|.:. .|...::::..|.|..||...|......:|.:...|.|..
Human   620 SFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEM 684

  Fly   588 INY-----DFDLSDQSGENSTADESKLNLDEF-DPL--------AQKGLVAKPPPPLPETSLLDS 638
            :.|     :.||.|.....|.||      .|| .||        |||.|...|...|........
Human   685 VRYLLEWTEEDLEDAEDTVSAAD------PEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQD 743

  Fly   639 TTDSLIDSEVPGTAVLLPSPLKPEVSNYRGFSNFD--IP-SISCNTGDF 684
            .:..|..:.:.|.|.|:|..||...:  .|..|.|  :| .::|..|.|
Human   744 GSSPLHVAALHGRADLIPLLLKHGAN--AGARNADQAVPLHLACQQGHF 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rabex-5	NP_612093.1	zf-A20	17..40	CDD:280010
Rabex-5	NP_612093.1	VPS9	274..373	CDD:280383	30/106 (28%)
ANKRD27	NP_115515.2	Sufficient for GEF activity towards RAB21. /evidence=ECO:0000269\|PubMed:16525121	1..372		55/254 (22%)
		VPS9	264..363	CDD:308039	29/106 (27%)
		Sufficient for interaction with VPS29. /evidence=ECO:0000269\|PubMed:24856514	396..460		13/76 (17%)
		Interaction with RAB32. /evidence=ECO:0000250\|UniProtKB:Q3UMR0	451..730		55/286 (19%)
		Interaction with RAB38. /evidence=ECO:0000250\|UniProtKB:Q3UMR0, ECO:0000269\|PubMed:18477474	451..600		24/150 (16%)
		ANK	458..585	CDD:238125	18/128 (14%)
		ANK repeat	462..493	CDD:293786	5/30 (17%)
		ANK repeat	495..526	CDD:293786	7/32 (22%)
		ANK repeat	564..595	CDD:293786	6/30 (20%)
		Ank_2	<567..>896	CDD:330894	55/232 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	625..665		8/39 (21%)
		Required for interaction with VAMP7. /evidence=ECO:0000250\|UniProtKB:Q3UMR0, ECO:0000269\|PubMed:19745841, ECO:0000269\|PubMed:23104059	658..707		12/48 (25%)
		ANK repeat	673..741	CDD:293786	20/73 (27%)
		Sufficient for interaction with VPS29. /evidence=ECO:0000269\|PubMed:24856514	692..746		16/59 (27%)
		ANK	738..863	CDD:238125	14/55 (25%)
		ANK repeat	743..774	CDD:293786	8/32 (25%)
		ANK 8	743..772		7/30 (23%)
		ANK 9	776..805		5/15 (33%)
		ANK repeat	780..807	CDD:293786	4/11 (36%)
		ANK repeat	809..840	CDD:293786
		ANK 10	809..838
		ANK repeat	842..873	CDD:293786
		ANK 11	842..871
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	987..1050
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2319
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810