DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rabex-5 and ANKRD27

DIOPT Version :10

Sequence 1:NP_612093.1 Gene:Rabex-5 / 38144 FlyBaseID:FBgn0262937 Length:696 Species:Drosophila melanogaster
Sequence 2:NP_115515.2 Gene:ANKRD27 / 84079 HGNCID:25310 Length:1050 Species:Homo sapiens


Alignment Length:699 Identity:144/699 - (20%)
Similarity:236/699 - (33%) Gaps:199/699 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   142 LRIPDDGKRKLKLEIQRLDSDIRKY---MNGNGGKNINELSDLVQNAYTKVSDIVHNDPSFEIAT 203
            |:..:|.:..|....:|.|.:|..:   ......|::....|.....|||....:..|...::..
Human   135 LKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANALYTKCLQQLLRDSHLKMLA 199

  Fly   204 NEDRDSAIDFFEKVVMTQNHKFLFSPYF----TTDEDSDVKVQKRIRQLSWITAKHLDCSIDEVN 264
            .:  ::.::..::.|....|..:::..|    |.:...|....|..|.|..:..|.:.     |.
Human   200 KQ--EAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIG-----VK 257

  Fly   265 SEARDLVYNAISELVGIDSYYSPQEKLQCTWRCCRHIFELLKRATGGPAS--------ADDFLPA 321
            .|....:..|..||..::...|||:||.    |.|.:.:|:   |..|:.        |||.|..
Human   258 PEFSFNIPRAKRELAQLNKCTSPQQKLV----CLRKVVQLI---TQSPSQRVNLETMCADDLLSV 315

  Fly   322 LIFVVLKANPVRLHSNINFVTRFTNASRLMSGESGYYFTNLCSAIAFIENLNGESLGVSSEEFE- 385
            |:::::|.......:|::::..| ..|.|...|.||..|:..:||.:|..   .||.....|.| 
Human   316 LLYLLVKTEIPNWMANLSYIKNF-RFSSLAKDELGYCLTSFEAAIEYIRQ---GSLSAKPPESEG 376

  Fly   386 -----------ALMSGQQPYSTPWESALLACESLHLISENMKRMEMLQKRNALISSGITSFEKEL 439
                       :|:|  |..|:|.:     |...|:.|.|.|.:|.|..:.        ..:|:.
Human   377 FGDRLFLKQRMSLLS--QMTSSPTD-----CLFKHIASGNQKEVERLLSQE--------DHDKDT 426

  Fly   440 I-----------DFQREVTERVD--TVI--------AKAPLNLLPIKTPAFLI------------ 471
            :           |.::.|:.|::  :|:        ...||::..:...|.||            
Human   427 VQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNA 491

  Fly   472 ----GQARAHLLNESEAG---------HYQANM----------LH-------------------- 493
                |....||  ..:.|         ||:|:.          ||                    
Human   492 TDYHGATPLHL--ACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVE 554

  Fly   494 ------GGSLTSQSLTAAG-----GLVKPA---AASKESGLSLKDT-----------SMSSMGRL 533
                  |.......|..|.     |:::..   .||.|....||:|           |:.....|
Human   555 SCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHL 619

  Fly   534 S----------PLQQNVQPADHLF-ASPIFNYTAFDAVSLLEEPVPDANTDVLMLGSEFQGGLTN 587
            |          |:|...:..|.:. .|...::::..|.|..||...|......:|.:...|.|..
Human   620 SFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEM 684

  Fly   588 INY-----DFDLSDQSGENSTADESKLNLDEF-DPL--------AQKGLVAKPPPPLPETSLLDS 638
            :.|     :.||.|.....|.||      .|| .||        |||.|...|...|........
Human   685 VRYLLEWTEEDLEDAEDTVSAAD------PEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQD 743

  Fly   639 TTDSLIDSEVPGTAVLLPSPLKPEVSNYRGFSNFD--IP-SISCNTGDF 684
            .:..|..:.:.|.|.|:|..||...:  .|..|.|  :| .::|..|.|
Human   744 GSSPLHVAALHGRADLIPLLLKHGAN--AGARNADQAVPLHLACQQGHF 790

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rabex-5NP_612093.1 zf-A20 17..40 CDD:460313
DUF5601 163..220 CDD:465668 8/59 (14%)
VPS9 274..373 CDD:460489 30/106 (28%)
ANKRD27NP_115515.2 Sufficient for GEF activity towards RAB21. /evidence=ECO:0000269|PubMed:16525121 1..372 55/254 (22%)
VPS9 264..363 CDD:460489 29/106 (27%)
Sufficient for interaction with VPS29. /evidence=ECO:0000269|PubMed:24856514 396..460 13/76 (17%)
ANKRD27_zf1 429..468 CDD:439265 5/38 (13%)
Interaction with RAB32. /evidence=ECO:0000250|UniProtKB:Q3UMR0 451..730 55/286 (19%)
Interaction with RAB38. /evidence=ECO:0000250|UniProtKB:Q3UMR0, ECO:0000269|PubMed:18477474 451..600 24/150 (16%)
ANKYR <459..616 CDD:440430 25/158 (16%)
ANK repeat 462..493 CDD:293786 5/30 (17%)
ANK repeat 495..526 CDD:293786 7/32 (22%)
ANK repeat 564..595 CDD:293786 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 625..665 8/39 (21%)
Required for interaction with VAMP7. /evidence=ECO:0000250|UniProtKB:Q3UMR0, ECO:0000269|PubMed:19745841, ECO:0000269|PubMed:23104059 658..707 12/48 (25%)
ANKYR 673..932 CDD:440430 34/126 (27%)
ANK repeat 673..741 CDD:293786 20/73 (27%)
Sufficient for interaction with VPS29. /evidence=ECO:0000269|PubMed:24856514 692..746 16/59 (27%)
ANK repeat 743..774 CDD:293786 8/32 (25%)
ANK 8 743..772 7/30 (23%)
ANK 9 776..805 5/15 (33%)
ANK repeat 780..807 CDD:293786 4/11 (36%)
ANK repeat 809..840 CDD:293786
ANK 10 809..838
ANK repeat 842..873 CDD:293786
ANK 11 842..871
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 987..1050
Blue background indicates that the domain is not in the aligned region.

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