DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rabex-5 and rin3

DIOPT Version :9

Sequence 1:	NP_612093.1	Gene:	Rabex-5 / 38144	FlyBaseID:	FBgn0262937	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	XP_001339622.2	Gene:	rin3 / 799244	ZFINID:	ZDB-GENE-030131-8871	Length:	1048	Species:	Danio rerio

Alignment Length:	469	Identity:	84/469 - (17%)
Similarity:	169/469 - (36%)	Gaps:	145/469 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 REKFNDKQRKLKQTGGETGPGSSSS-----VATL--------------DRRSPQHAHLQG----- 80
            |.|.::||...:....|..|....|     ||:|              |.::||...:..
Zfish   454 RRKLSEKQASEEPAQQEVNPEPEDSTQQVPVASLICLDDGVEERDKPMDPKTPQVQEVPAEESKV 518

  Fly    81 ---------KVEQQVRKPS-------DKEQDNLGTL-----QKKKFTAVLQKT----------LQ 114
                     :|..|.::|:       .|.|.:...|     |....|..|:.:          :.
Zfish   519 ANGAPMVTPEVASQPKRPNAPVPPPRKKRQSHCSNLSSSTPQNTTSTVPLKSSSPSPVRHSLCIN 583

  Fly   115 AGAQKITQQRGHVPD-------------PTEGQ--------FLLQLRQLRIPDDGKRKLKL-EIQ 157
            |...|::....:.||             .||.:        .|::.....:.|..|::|.: .:.
Zfish   584 ATHPKVSDVSLYSPDGGAPLDHDSYSTSSTEEEADANMATGALIKRTPTIMLDRAKQRLSMVSMA 648

  Fly   158 RLDSDIRKYMNGNG--GKNINELSDLVQNAYTKVSDIVHNDPSFEIATNEDRDSAIDFFEKV--V 218
            .|.:.:..:||.:.  .|.|.|:|   ::..|...::|.:..:|.:.|.....|:.:..:::  :
Zfish   649 NLSNVLTGFMNADRKLQKRIVEMS---RDGNTYFGNLVKDYRAFTLDTMRKHTSSTEMLQEIRQM 710

  Fly   219 MTQNHKFLFSPYFTTDEDSDVKVQKRIRQLSWITAKHLDCSID-----EVNSEARDLVYNAISE- 277
            :||...:|.       :.:::   :.:::.:..:.:.|:..|:     .|....|:.|||.:.:
Zfish   711 ITQLKSYLI-------QSAEL---QNVQETAAYSEEKLEIIIEAAICKSVLKPLREAVYNGLKDI 765

  Fly   278 -------------------------------------------LVGIDSYYSPQEKLQCTWRCCR 299
                                                       |..:...||||:|:....:.|:
Zfish   766 HSRAGNLKKLKENQQVVQGTTTTDLGVITSVPETPIMEKIQTRLGNLHQEYSPQKKIDLLLKTCK 830

  Fly   300 HIFELLKRATGGPA-SADDFLPALIFVVLKANPVRLHSNINFVTRFTNASRLMSGESGYYFTNLC 363
            .|:|.:.....|.| .||||||.|::|:.:.|...|..::.::....:.: |..||..||.|...
Zfish   831 IIYESMSVGCPGRAHGADDFLPVLMYVLARCNITALLLDVEYMMELMDPA-LQLGEGSYYLTTTY 894

  Fly   364 SAIAFIENLNGESL 377
            .|:..|:|.:.:::
Zfish   895 GALEHIKNFDKQAV 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rabex-5	NP_612093.1	zf-A20	17..40	CDD:280010	84/469 (18%)
Rabex-5	NP_612093.1	VPS9	274..373	CDD:280383	30/143 (21%)
rin3	XP_001339622.2	SH2_RIN3	149..249	CDD:198258
		VPS9	803..905	CDD:280383	30/102 (29%)
		UBQ	942..1024	CDD:294102
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584026
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840