DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rabex-5 and RIN3

DIOPT Version :9

Sequence 1:	NP_612093.1	Gene:	Rabex-5 / 38144	FlyBaseID:	FBgn0262937	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_079108.3	Gene:	RIN3 / 79890	HGNCID:	18751	Length:	985	Species:	Homo sapiens

Alignment Length:	397	Identity:	73/397 - (18%)
Similarity:	142/397 - (35%)	Gaps:	91/397 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 QNEGLCSMCFREKFNDKQRKLKQTGGETGPGSSSSVATLDRRSPQHAHLQGKVEQQVRKPSDKEQ 94
            :|..||:          |....:|.....|....|.|:  :...||...|.....|   .|.:.:
Human   479 ENAELCT----------QAMALETPTPGPPREGQSPAS--QAGTQHPPAQATAHSQ---SSPEFK 528

  Fly    95 DNLGTLQKKKFTAVLQKTLQAGAQKITQQRGHVPDPTEGQFLLQLRQLRIPDD--------GKRK 151
            .:|.:|......:|:          .|.|..:....||.    :|.|...|..        ||.:
Human   529 GSLASLSDSLGVSVM----------ATDQDSYSTSSTEE----ELEQFSSPSVKKKPSMILGKAR 579

  Fly   152 LKLEIQRLDSDIRKYMNGNGGKNINELSDLVQNAYTKVSDIVHNDPSFEIATNEDRDSAIDFFEK 216
            .:|......|....::: |..|...::.:|.|:..:....:|.:...:.:.....:.|:.:..::
Human   580 HRLSFASFSSMFHAFLS-NNRKLYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQE 643

  Fly   217 V--VMTQ---------NHKFLFSPYFTTDEDSDVKVQKRI------------------------- 245
            :  :|||         ..|.|..|...::|:.:..|:..:
Human   644 IRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQIHSKDGS 708

  Fly   246 ------RQLSWITAKHLD----CSIDEVNSEARDLVYNAISELVGIDSYYSPQEKLQCTWRCCRH 300
                  .||..:.....|    .|:.||     .::...:.:...:...|||::|:....:.|:.
Human   709 LQQLKENQLVILATTTTDLGVTTSVPEV-----PMMEKILQKFTSMHKAYSPEKKISILLKTCKL 768

  Fly   301 IFELLKRAT-GGPASADDFLPALIFVVLKANPVRLHSNINFVTRFTNASRLMSGESGYYFTNLCS 364
            |::.:.... |.|..||||||.|::|:.::|...:..|:.::....:.: |..||..||.|....
Human   769 IYDSMALGNPGKPYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDPA-LQLGEGSYYLTTTYG 832

  Fly   365 AIAFIEN 371
            |:..|::
Human   833 ALEHIKS 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rabex-5	NP_612093.1	zf-A20	17..40	CDD:280010	3/9 (33%)
Rabex-5	NP_612093.1	VPS9	274..373	CDD:280383	26/99 (26%)
RIN3	NP_079108.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		SH2_RIN3	52..153	CDD:198258
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..202
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..293
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..531		13/66 (20%)
		FtsZ_alphas_C	315..414	CDD:274601
		Interaction with RAB5B. /evidence=ECO:0000269\|PubMed:12972505	587..732		18/145 (12%)
		VPS9	740..842	CDD:280383	26/101 (26%)
		UBQ	882..961	CDD:294102
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149886
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840