DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rabex-5 and Rabgef1

DIOPT Version :9

Sequence 1:	NP_612093.1	Gene:	Rabex-5 / 38144	FlyBaseID:	FBgn0262937	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	XP_006504509.1	Gene:	Rabgef1 / 56715	MGIID:	1929459	Length:	510	Species:	Mus musculus

Alignment Length:	491	Identity:	162/491 - (32%)
Similarity:	251/491 - (51%)	Gaps:	48/491 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTAARPPSLRLGQQDLKCRSGCGFYGTPQNEGLCSMCFREKFND-KQRKLKQTGGETGPGSSSS 64
            ||..:....:.:.|.:|.|:.|||:||.|..:|.||.|:||:::. :||::::         ...
Mouse    19 MSLKSERRGIHVDQSELLCKKGCGYYGNPAWQGFCSKCWREEYHKARQRQIQE---------DWE 74

  Fly    65 VATLDRRSPQHAHLQGKVEQ--------QVRKPSDKEQDNLGTLQKKKFTAVLQKTLQAGAQKIT 121
            :|...:|..:.|....:..|        :..:....|:....|..||.|:|    :.:||::|..
Mouse    75 LAERLQREEEEAFASSQSSQGAQSLTFSKFEEKKTNEKTRKVTTVKKFFSA----SSRAGSKKAE 135

  Fly   122 QQRGHVPDPTEGQFLLQLRQLRIPDDGKRKLKLEI--------QRLDSDIRKYMNGNGGK---NI 175
            .|....|.|:..      ||..|..|...|..::.        |.:....:.::.....|   :|
Mouse   136 IQEAKAPSPSIN------RQTSIETDRVTKEFIDFLKTFHKTGQEVYKQTKMFLEAMPYKRDLSI 194

  Fly   176 NELSDLVQNAYTKVSDIVHNDPSFEIATNEDRDSAIDFFEKVVMTQNHKFLFSPYFTTDEDSDVK 240
            .|.|:..|:.|..|::.:.....   ...|..:..:|..||.:||:.:||:|.|..|.||..|:.
Mouse   195 EEQSECTQDFYQNVAERMQTRGK---VPPEKVEKIMDQIEKHIMTRLYKFVFCPETTDDEKKDLA 256

  Fly   241 VQKRIRQLSWITAKHLDCSIDEVNSEARDLVYNAISELVGIDSYYSPQEKLQCTWRCCRHIFELL 305
            :|||||.|.|:|.:.|...::|...|..|:|..||::::.:||...|::||.|..||.:|||..:
Mouse   257 IQKRIRALHWVTPQMLCVPVNEEIPEVSDMVVKAITDIIEMDSKRVPRDKLACITRCSKHIFNAI 321

  Fly   306 KRATGGPASADDFLPALIFVVLKANPVRLHSNINFVTRFTNASRLMSGESGYYFTNLCSAIAFIE 370
            |.....|||||||||.||::|||.||.||.|||.::|||.|.||||:||.||||||||.|:||||
Mouse   322 KITKNEPASADDFLPTLIYIVLKGNPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIE 386

  Fly   371 NLNGESLGVSSEEFEALMSGQ----QPYSTPWESALLACESLHLISENMKRMEMLQKRNALISSG 431
            .|:.:||.:|.|:|:..||||    :..|..|...  ||..:..:.:|:..:..|.:|...|.:.
Mouse   387 KLDAQSLNLSQEDFDRYMSGQTSPRKQESESWPPE--ACLGVKQMYKNLDLLSQLNERQERIMNE 449

  Fly   432 ITSFEKELIDFQREVTERVDTVIAKAPLNLLPIKTP 467
            ....||:|||:...:.:.|..::.|.||.:.|...|
Mouse   450 AKKLEKDLIDWTDGIAKEVQDIVEKYPLEIKPPNQP 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rabex-5	NP_612093.1	zf-A20	17..40	CDD:280010	12/22 (55%)
Rabex-5	NP_612093.1	VPS9	274..373	CDD:280383	58/98 (59%)
Rabgef1	XP_006504509.1	zf-A20	35..58	CDD:366793	12/22 (55%)
		DUF5601	177..239	CDD:375592	13/64 (20%)
		VPS9	289..389	CDD:366977	58/99 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839937
Domainoid	1	1.000	128	1.000	Domainoid score	I5313
eggNOG	1	0.900	-	-		E1_KOG3173
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8720
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3152
Isobase	1	0.950	-	0	Normalized mean entropy	S3044
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D944088at2759
OrthoFinder	1	1.000	-	-		FOG0002652
OrthoInspector	1	1.000	-	-		oto92151
orthoMCL	1	0.900	-	-		OOG6_102142
Panther	1	1.100	-	-	LDO	PTHR23101
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1663
SonicParanoid	1	1.000	-	-		X2025
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740