DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rabex-5 and gapvd1

DIOPT Version :9

Sequence 1:NP_612093.1 Gene:Rabex-5 / 38144 FlyBaseID:FBgn0262937 Length:696 Species:Drosophila melanogaster
Sequence 2:XP_009302368.1 Gene:gapvd1 / 436693 ZFINID:ZDB-GENE-040718-117 Length:1484 Species:Danio rerio


Alignment Length:438 Identity:109/438 - (24%)
Similarity:182/438 - (41%) Gaps:109/438 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LGQQDLKCRSGCGFYGTPQNEGLCSMCFRE----------------KFNDKQRKLKQTGGETGPG 60
            :||:  .||.|...:.:|::|.|.::...:                .|:|.::||:     ....
Zfish  1077 VGQE--SCREGDSEHDSPKDEALQNISADDLPDSASQTAPPQDKTFSFSDIKKKLR-----LALC 1134

  Fly    61 SSSSV-------ATLDRRSPQHAHLQGKVEQQVRKPSDKE-----QDNLG---TLQKKKFTAVLQ 110
            |:.||       ||.....|.||           .|.|.|     :..|.   .||.|...|.:|
Zfish  1135 SADSVVFPIIPPATTRNGLPDHA-----------DPEDNEIVCFLKVQLAEAINLQDKNQMAQIQ 1188

  Fly   111 KT---------------LQAGAQKITQQRGHVPDPT---EG--------QFLLQLRQLRIPDDGK 149
            :|               |.|.|:...::..::...|   :|        :.||| |.||..:...
Zfish  1189 ETTRCVSHLDPRTCRKLLTAMAEDYRKRAPYIAYLTRCRQGLQTSQAHLERLLQ-RVLRDKEVAN 1252

  Fly   150 RK-----LKLEIQRLDSDIRKYMNGNGGKNINE-----LSDLVQNAYTKVSDIVHNDPSFEIATN 204
            |.     ::|.::.::|.:..::....|....:     :.|.::..|..::    :|..::.|:.
Zfish  1253 RYFTTVCVRLLLEHMESKMLDFIKAFQGCTAADDKTAAVEDFLRYLYGAMA----HDAIWQYASE 1313

  Fly   205 EDRDSAIDFFEKVVMTQNHKFLFSPYFTTDEDSDVKVQKRIRQLS-WITAKHLDCSIDEVNSEAR 268
            |....|....|:.||.:..|..|.|....|...|....:.|::|| .::|.|....|.|      
Zfish  1314 EQLQDAQMAIERSVMNRIFKLAFYPNQDGDIHRDELFHEHIQRLSRVVSANHKALQIPE------ 1372

  Fly   269 DLVY-------NAISELVGIDSYYSPQEKLQCTWRCCRHIFELLKRAT-GGPASADDFLPALIFV 325
              ||       :|.:|:..|::|.:|::|:||..|.|..|..||..|. .....||||:|.|:||
Zfish  1373 --VYLKEAPWPSAQAEIKTINAYKTPRDKVQCILRMCSTIMNLLSLANEDAVPGADDFVPVLVFV 1435

  Fly   326 VLKANPVRLHSNINFVTRFTNASRLMSGESGYYFTNLCSAIAFIENLN 373
            ::||||..|.|.|.::..| .|||| |||..|::....:|:.||:.::
Zfish  1436 LIKANPPCLLSTIQYINNF-YASRL-SGEECYWWMQFTAAVEFIKTID 1481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rabex-5NP_612093.1 zf-A20 17..40 CDD:280010 6/22 (27%)
VPS9 274..373 CDD:280383 41/99 (41%)
gapvd1XP_009302368.1 RasGAP_RAP6 84..449 CDD:213331
VPS9 1380..1481 CDD:280383 41/102 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG2319
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D944088at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

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