Protein Alignment Rabex-5 and rabgef1

DIOPT Version :10

• Sequence 1: NP_612093.1
• Gene: Rabex-5 / 38144
• FlyBaseID: FBgn0262937
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: XP_012812130.2
• Gene: rabgef1 / 394956
• XenbaseID: XB-GENE-5952242
• Length: 492
• Species: Xenopus tropicalis
• Alignment Length: 509
• Identity: 174/509 - (34%)
• Similarity: 258/509 - (50%)
• Gaps: 61/509 - (11%)

  Fly     1 MSTAARPPSLRLGQQDLKCRSGCGFYGTPQNEGLCSMCFREKFNDKQRKLKQTGGETGPGSSSSV 65
            ||.......:.:.|.:|.|:.|||:||.|..:|.||.|:||::...::|..|...|        :
 Frog     1 MSLKTERRGIHVDQSELLCKKGCGYYGNPAWQGFCSKCWREEYQKARQKQIQDDWE--------L 57

  Fly    66 ATLDRRSPQHAHLQGKVEQ---------QVRKPSDKEQDNLGTLQKKKFTAVLQKTLQAGAQKIT 121
            |...:|..:.|:...:..|         :..:....|:....|..||.|||   .|.....:.|.
 Frog    58 AERLQREEEEAYASSQGAQAGPQSLTFSKFEEKKSNEKTRKVTTVKKFFTA---STKSLPKKDIK 119

  Fly   122 QQRGHVPDPTEGQFLLQLRQLRIPDDGKRKLKLEI----QRLDSDIRKY-------MNGNGGKNI 175
            :.:.  |.|:..      ||..:..|...|..:|.    |:...|:.|.       |......||
 Frog   120 EAKS--PSPSLS------RQYSLETDRVSKDFIEFLKTYQKAGHDVYKMSKIFLEAMYHKRESNI 176

  Fly   176 NELSDLVQNAYTKVSDIVHNDPSFEIATNEDRDSAIDFFEKVVMTQNHKFLFSPYFTTDEDSDVK 240
            :|.|:..|:.|...::.:.   .:...:.:..:...|..|:.:||:.:|.:|.|..|.||..|:.
 Frog   177 DEQSEFTQDFYQNTAEKLQ---MYWKVSPDKVEKVTDQIERFIMTRLYKHVFCPETTDDEKKDLT 238

  Fly   241 VQKRIRQLSWITAKHLDCSIDEVNSEARDLVYNAISELVGIDSYYSPQEKLQCTWRCCRHIFELL 305
            ||||||.|.|:|.:.|...::|..:|..|:|..||::::.:||...|::||.|..||.:|||..:
 Frog   239 VQKRIRALHWVTPQMLCVPVNEDIAEVSDMVVKAITDIIEMDSKRIPRDKLACITRCSKHIFNAI 303

  Fly   306 KRATGGPASADDFLPALIFVVLKANPVRLHSNINFVTRFTNASRLMSGESGYYFTNLCSAIAFIE 370
            |.....|||||||||.||::||||||.||.|||.::|||.|.||||:||.||||||||.|:||||
 Frog   304 KITKNEPASADDFLPTLIYIVLKANPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIE 368

  Fly   371 NLNGESLGVSSEEFEALMSGQQPYSTP-------WESALLACESLHLISENMKRMEMLQKRNALI 428
            .|:.:||.:|.|||...||||   ::|       |.:.  .|..:..:..|:..:..|.||...|
 Frog   369 KLDAQSLNLSEEEFSRYMSGQ---ASPKKQDLENWPAD--TCPGVKQMHRNLDLLTQLSKRQEHI 428

  Fly   429 SSGITSFEKELIDFQREVTERVDTVIAKAPLNLLPIKTPAFLIGQARAHLLNES 482
            .:|....||:|||:..:||:.|..::.|.|||   |||.:    ||.|.|.:|:
 Frog   429 VNGAKKLEKDLIDWTDDVTKEVKDIVEKYPLN---IKTAS----QALAALESEN 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rabex-5	NP_612093.1	zf-A20	17..40	CDD:460313	12/22 (55%)
		DUF5601	163..220	CDD:465668	10/63 (16%)
		VPS9	274..373	CDD:460489	59/98 (60%)
rabgef1	XP_012812130.2	zf-A20	17..40	CDD:460313	12/22 (55%)
		DUF5601	159..221	CDD:465668	12/64 (19%)
		VPS9	271..371	CDD:460489	59/99 (60%)