DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rabex-5 and rabgef1

DIOPT Version :9

Sequence 1:	NP_612093.1	Gene:	Rabex-5 / 38144	FlyBaseID:	FBgn0262937	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	XP_009303637.1	Gene:	rabgef1 / 393816	ZFINID:	ZDB-GENE-040426-1486	Length:	554	Species:	Danio rerio

Alignment Length:	544	Identity:	169/544 - (31%)
Similarity:	261/544 - (47%)	Gaps:	97/544 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTAARPPSLRLGQQDLKCRSGCGFYGTPQNEGLCSMCFREKFND-KQRKLKQTGGETGPGSSSS 64
            ||..:....:.:.|.:|.|:.|||:||....:||||.|:|:::.. :||:::         ...:
Zfish     1 MSQRSERRGIHVDQSELLCKKGCGYYGNAAWQGLCSKCWRDEYQKARQRQIQ---------DDWA 56

  Fly    65 VATLDRRSPQHAHLQGKVEQQVRKPSDKEQDNLGTLQK----------------KKFTAVLQKTL 113
            :|...:|..:.|::......|.:.|....|.:|.|..|                |||.:...:|
Zfish    57 LAEKLQREEEAAYVSSHSSSQTQPPQSHSQHSLATFSKFEEKKTNEKTRKVTTVKKFFSPSSRT- 120

  Fly   114 QAGAQKITQQRGHVPDPTE---------GQFLLQ-------------------LRQLRIPDDGK- 149
              ..:|:..::....:..|         |:.||:                   :.:||...:.|
Zfish   121 --APKKVPPEKEREKEKEEKLPGRRESHGENLLRDLKGIFTQPWEMSSPTEALVSRLRESHEAKT 183

  Fly   150 ------RKLKLEIQRLDSDI------------------RKYMNGNGGK----NINELSDLVQNAY 186
                  |:..:|..|:..|.                  |.:::..|.|    :..|||:.||:.|
Zfish   184 PSPSITRQSSIETDRVSRDFVEFLKTLHKPGREIHKHSRAFIDSMGNKKQDLSAEELSECVQDFY 248

  Fly   187 TKVSDIVHNDPSFEIATNEDRDSAIDFFEKVVMTQNHKFLFSPYFTTDEDSDVKVQKRIRQLSWI 251
            ..:||.:.|  .|: .::|..|..:|..||.:||:.:|.:|.|..:.||..|:..|.|||.|.|:
Zfish   249 QGMSDRLLN--HFK-GSSEKVDRVMDQVEKYIMTRLYKSVFCPETSDDEKKDLATQHRIRALHWV 310

  Fly   252 TAKHLDCSIDEVNSEARDLVYNAISELVGIDSYYSPQEKLQCTWRCCRHIFELLKRATGGPASAD 316
            |.:.|...::|...|..|.|..||::::.:||...|::||.|...|.:|||..::.....|||||
Zfish   311 TIQMLCVPVEEEIPEVSDSVVKAITDIIEMDSKRVPRDKLACITSCSKHIFNAIRVTKNEPASAD 375

  Fly   317 DFLPALIFVVLKANPVRLHSNINFVTRFTNASRLMSGESGYYFTNLCSAIAFIENLNGESLGVSS 381
            ||||.||::||||||.||.|||.::|||.|.||||:||.||||||||.|:||||.|:.:||.:|.
Zfish   376 DFLPTLIYIVLKANPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSP 440

  Fly   382 EEFEALMSGQ-------QPYSTPWESALLACESLHLISENMKRMEMLQKRNALISSGITSFEKEL 439
            |:||..||||       .|...| :|.......|..|..|:..:..|:||...:..|..|.|.||
Zfish   441 EDFERYMSGQASPRRQDDPAGWP-QSGSRVNPVLTQIQHNLSVLSSLEKRQQQVIEGAQSLEAEL 504

  Fly   440 IDFQREVTERVDTVIAKAPLNLLP 463
            .::|..|...|..::.:.||::.|
Zfish   505 TEWQESVAREVQEILERYPLDIKP 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rabex-5	NP_612093.1	zf-A20	17..40	CDD:280010	12/22 (55%)
Rabex-5	NP_612093.1	VPS9	274..373	CDD:280383	57/98 (58%)
rabgef1	XP_009303637.1	zf-A20	17..40	CDD:280010	12/22 (55%)
rabgef1	XP_009303637.1	VPS9	332..432	CDD:280383	57/99 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584032
Domainoid	1	1.000	129	1.000	Domainoid score	I5211
eggNOG	1	0.900	-	-		E1_KOG3173
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8720
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3157
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D320193at33208
OrthoFinder	1	1.000	-	-		FOG0002652
OrthoInspector	1	1.000	-	-		otm25816
orthoMCL	1	0.900	-	-		OOG6_102142
Panther	1	1.100	-	-	LDO	PTHR23101
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1663
SonicParanoid	1	1.000	-	-		X2025
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790