Protein Alignment Rabex-5 and rabgef1

DIOPT Version :10

• Sequence 1: NP_612093.1
• Gene: Rabex-5 / 38144
• FlyBaseID: FBgn0262937
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: XP_009303637.1
• Gene: rabgef1 / 393816
• ZFINID: ZDB-GENE-040426-1486
• Length: 554
• Species: Danio rerio
• Alignment Length: 544
• Identity: 169/544 - (31%)
• Similarity: 261/544 - (47%)
• Gaps: 97/544 - (17%)

  Fly     1 MSTAARPPSLRLGQQDLKCRSGCGFYGTPQNEGLCSMCFREKFND-KQRKLKQTGGETGPGSSSS 64
            ||..:....:.:.|.:|.|:.|||:||....:||||.|:|:::.. :||:::         ...:
Zfish     1 MSQRSERRGIHVDQSELLCKKGCGYYGNAAWQGLCSKCWRDEYQKARQRQIQ---------DDWA 56

  Fly    65 VATLDRRSPQHAHLQGKVEQQVRKPSDKEQDNLGTLQK----------------KKFTAVLQKTL 113
            :|...:|..:.|::......|.:.|....|.:|.|..|                |||.:...:|
Zfish    57 LAEKLQREEEAAYVSSHSSSQTQPPQSHSQHSLATFSKFEEKKTNEKTRKVTTVKKFFSPSSRT- 120

  Fly   114 QAGAQKITQQRGHVPDPTE---------GQFLLQ-------------------LRQLRIPDDGK- 149
              ..:|:..::....:..|         |:.||:                   :.:||...:.|
Zfish   121 --APKKVPPEKEREKEKEEKLPGRRESHGENLLRDLKGIFTQPWEMSSPTEALVSRLRESHEAKT 183

  Fly   150 ------RKLKLEIQRLDSDI------------------RKYMNGNGGK----NINELSDLVQNAY 186
                  |:..:|..|:..|.                  |.:::..|.|    :..|||:.||:.|
Zfish   184 PSPSITRQSSIETDRVSRDFVEFLKTLHKPGREIHKHSRAFIDSMGNKKQDLSAEELSECVQDFY 248

  Fly   187 TKVSDIVHNDPSFEIATNEDRDSAIDFFEKVVMTQNHKFLFSPYFTTDEDSDVKVQKRIRQLSWI 251
            ..:||.:.|  .|: .::|..|..:|..||.:||:.:|.:|.|..:.||..|:..|.|||.|.|:
Zfish   249 QGMSDRLLN--HFK-GSSEKVDRVMDQVEKYIMTRLYKSVFCPETSDDEKKDLATQHRIRALHWV 310

  Fly   252 TAKHLDCSIDEVNSEARDLVYNAISELVGIDSYYSPQEKLQCTWRCCRHIFELLKRATGGPASAD 316
            |.:.|...::|...|..|.|..||::::.:||...|::||.|...|.:|||..::.....|||||
Zfish   311 TIQMLCVPVEEEIPEVSDSVVKAITDIIEMDSKRVPRDKLACITSCSKHIFNAIRVTKNEPASAD 375

  Fly   317 DFLPALIFVVLKANPVRLHSNINFVTRFTNASRLMSGESGYYFTNLCSAIAFIENLNGESLGVSS 381
            ||||.||::||||||.||.|||.::|||.|.||||:||.||||||||.|:||||.|:.:||.:|.
Zfish   376 DFLPTLIYIVLKANPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSP 440

  Fly   382 EEFEALMSGQ-------QPYSTPWESALLACESLHLISENMKRMEMLQKRNALISSGITSFEKEL 439
            |:||..||||       .|...| :|.......|..|..|:..:..|:||...:..|..|.|.||
Zfish   441 EDFERYMSGQASPRRQDDPAGWP-QSGSRVNPVLTQIQHNLSVLSSLEKRQQQVIEGAQSLEAEL 504

  Fly   440 IDFQREVTERVDTVIAKAPLNLLP 463
            .::|..|...|..::.:.||::.|
Zfish   505 TEWQESVAREVQEILERYPLDIKP 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rabex-5	NP_612093.1	zf-A20	17..40	CDD:460313	12/22 (55%)
		DUF5601	163..220	CDD:465668	18/78 (23%)
		VPS9	274..373	CDD:460489	57/98 (58%)
rabgef1	XP_009303637.1	zf-A20	17..40	CDD:460313	12/22 (55%)
		DUF5601	219..282	CDD:465668	20/65 (31%)
		VPS9	332..432	CDD:460489	57/99 (58%)