DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rabex-5 and Gapvd1

DIOPT Version :9

Sequence 1:	NP_612093.1	Gene:	Rabex-5 / 38144	FlyBaseID:	FBgn0262937	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_572704.1	Gene:	Gapvd1 / 32070	FlyBaseID:	FBgn0030286	Length:	1712	Species:	Drosophila melanogaster

Alignment Length:	451	Identity:	109/451 - (24%)
Similarity:	183/451 - (40%)	Gaps:	110/451 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QQDLKCRS-----GCGFYGT---PQNEGLCSMCFREKFNDKQRKLK--QTGGETGPGSSSSVATL 68
            |.|::..|     ||..:||   ..:|.:.:. :|.|.:.......  .||...|.||:.||..
  Fly  1278 QADIRSVSFDPSAGCDNFGTHYCDTSEDILAK-YRRKVSSSSEATNSDSTGNGHGVGSTGSVGA- 1340

  Fly    69 DRRSPQHAHLQGK---------VEQQVRKPSDKEQDNLGTLQKKKFTAV-----LQKTLQAG-AQ 118
              .:..|.|:.|.         |:|::|....:...:.|..::...|:.     ||..||.. ||
  Fly  1341 --AAHLHKHMNGGHIPGVVFGCVKQKLRTVLSRTDLHSGDFRQTSTTSTTMATPLQIYLQIQLAQ 1403

  Fly   119 KITQQR----GHVPD----------PTEGQFLLQL------------------RQLRIPDDGKRK 151
            .|:.||    .||.:          |..||.|.:|                  :||.:..:...:
  Fly  1404 CISLQRLPQISHVAEALRCLAQLERPQHGQLLAELQRDLERRQSYLQYLMRHRQQLLLRSEQLEQ 1468

  Fly   152 LKLEI-------QR--LDSDIRKYMNGNGGKNINELSDL-VQNAYTKVSD--IVHNDPSFEIATN 204
            |:..:       ||  |.:.:|.|:..:  :...:|... .:.|..:.||  :...:...|....
  Fly  1469 LEARLRGEARSSQRCLLQALVRMYLAWS--RQQEKLEQFQAEFAQLRASDERVELTEEFVESLLQ 1531

  Fly   205 EDRDSA-------ID----FFEKVVMTQNHKFLFSPYFTTDEDSDV-----------KVQKRIRQ 247
            |.|.||       :|    ..|::::.|.::.:..|    :||:||           |:|:.:.
  Fly  1532 ELRSSADLQDEWQVDAARVAIERMLLEQMYEQVMFP----NEDADVSRDEVLSAHIGKLQRFVH- 1591

  Fly   248 LSWITAKHLDCSIDEVNSEARDLVYNAISELVGIDSYYSPQEKLQCTWRCCRHIFELLKRATGGP 312
                .|....|...|...||....  |..:|..:.:|.:|:|||||...|...|..||:.::|..
  Fly  1592 ----PAHPALCIAQEYLGEAPWTF--AQQQLCHMAAYKTPREKLQCIINCISSIMSLLRMSSGRV 1650

  Fly   313 ASADDFLPALIFVVLKANPVRLHSNINFVTRFTNASRLMSGESGYYFTNLCSAIAFIENLN 373
            .:|||.||.||:||:.|||..|.|.:.:::.|  ..:.:.||..:|:|...|.:.||:.::
  Fly  1651 PAADDLLPVLIYVVIMANPPYLLSTVEYISCF--LGKKLEGEDEFYWTLFGSVVKFIKTMD 1709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rabex-5	NP_612093.1	zf-A20	17..40	CDD:280010	6/30 (20%)
Rabex-5	NP_612093.1	VPS9	274..373	CDD:280383	36/98 (37%)
Gapvd1	NP_572704.1	RasGAP_RAP6	90..460	CDD:213331
Gapvd1	NP_572704.1	VPS9	1609..1709	CDD:280383	36/103 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454064
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2319
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D944088at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23101
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850