DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rabex-5 and RABGEF1

DIOPT Version :9

Sequence 1:	NP_612093.1	Gene:	Rabex-5 / 38144	FlyBaseID:	FBgn0262937	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_001354670.1	Gene:	RABGEF1 / 27342	HGNCID:	17676	Length:	530	Species:	Homo sapiens

Alignment Length:	520	Identity:	166/520 - (31%)
Similarity:	256/520 - (49%)	Gaps:	68/520 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTAARPPSLRLGQQDLKCRSGCGFYGTPQNEGLCSMCFREKFNDKQRKLKQTGGETGPGSSSSV 65
            ||..:....:.:.|.||.|:.|||:||.|..:|.||.|:||:::..::|..|...|        :
Human     1 MSLKSERRGIHVDQSDLLCKKGCGYYGNPAWQGFCSKCWREEYHKARQKQIQEDWE--------L 57

  Fly    66 ATLDRRSPQHAHLQGKVEQQVRKPSDKEQDNLGTLQKKKFTAVLQKTLQA----GAQKITQQRGH 126
            |...:|..:.|....:..|..:..:..:.:...|.:|.:....::|...|    |::|..|: ..
Human    58 AERLQREEEEAFASSQSSQGAQSLTFSKFEEKKTNEKTRKVTTVKKFFSASSRVGSKKEIQE-AK 121

  Fly   127 VPDPTEGQFLLQLRQLRIPDDGKRKLKLEI--------QRLDSDIRKYMNGNGGK---NINELSD 180
            .|.|:..      ||..|..|...|..:|.        |.:....:.::.|...|   :|.|.|:
Human   122 APSPSIN------RQTSIETDRVSKEFIEFLKTFHKTGQEIYKQTKLFLEGMHYKRDLSIEEQSE 180

  Fly   181 LVQNAYTKVSD---------------------IVHNDP---SFEIATN------------EDRDS 209
            ..|:.|..|::                     :...||   :.:.|.|            |..:.
Human   181 CAQDFYHNVAERMQTRGKERRFHHVGQAGLELLTSGDPPASASQSAGNTGVEPPHPAVPPERVEK 245

  Fly   210 AIDFFEKVVMTQNHKFLFSPYFTTDEDSDVKVQKRIRQLSWITAKHLDCSIDEVNSEARDLVYNA 274
            .:|..||.:||:.:|::|.|..|.||..|:.:|||||.|.|:|.:.|...::|...|..|:|..|
Human   246 IMDQIEKYIMTRLYKYVFCPETTDDEKKDLAIQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKA 310

  Fly   275 ISELVGIDSYYSPQEKLQCTWRCCRHIFELLKRATGGPASADDFLPALIFVVLKANPVRLHSNIN 339
            |::::.:||...|::||.|..:|.:|||..:|.....|||||||||.||::|||.||.||.|||.
Human   311 ITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGNPPRLQSNIQ 375

  Fly   340 FVTRFTNASRLMSGESGYYFTNLCSAIAFIENLNGESLGVSSEEFEALMSGQ-QPYSTPWES-AL 402
            ::|||.|.||||:||.||||||||.|:||||.|:.:||.:|.|:|:..|||| .|.....|| :.
Human   376 YITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSP 440

  Fly   403 LACESLHLISENMKRMEMLQKRNALISSGITSFEKELIDFQREVTERVDTVIAKAPLNLLPIKTP 467
            .||..:..:.:|:..:..|.:|...|.:.....||:|||:...:...|..::.|.||.:.|...|
Human   441 DACLGVKQMYKNLDLLSQLNERQERIMNEAKKLEKDLIDWTDGIAREVQDIVEKYPLEIKPPNQP 505

Fly 468 467
Human 506 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rabex-5	NP_612093.1	zf-A20	17..40	CDD:280010	12/22 (55%)
Rabex-5	NP_612093.1	VPS9	274..373	CDD:280383	57/98 (58%)
RABGEF1	NP_001354670.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149890
Domainoid	1	1.000	127	1.000	Domainoid score	I5390
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8720
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3159
Isobase	1	0.950	-	0	Normalized mean entropy	S3044
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D320193at33208
OrthoFinder	1	1.000	-	-		FOG0002652
OrthoInspector	1	1.000	-	-		oto88586
orthoMCL	1	0.900	-	-		OOG6_102142
Panther	1	1.100	-	-	LDO	PTHR23101
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2025
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.810