DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rabex-5 and GAPVD1

DIOPT Version :9

Sequence 1:	NP_612093.1	Gene:	Rabex-5 / 38144	FlyBaseID:	FBgn0262937	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_056450.2	Gene:	GAPVD1 / 26130	HGNCID:	23375	Length:	1487	Species:	Homo sapiens

Alignment Length:	429	Identity:	101/429 - (23%)
Similarity:	167/429 - (38%)	Gaps:	115/429 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STAARPPSLRLGQQDLK-------C--------------RSGCGFYGTPQ-NEGLCSM------- 37
            |.||.|.......:|.|       |              |:|...:..|: ||.:|.:
Human  1114 SQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLTHSTRNGLPDHTDPEDNEIVCFLKVQIAEA 1178

  Fly    38 -----------------CFREKFNDKQRKLKQTGGETGPGSSSSVATLDR----RSPQHAHLQGK 81
                             |.....|...|||..:..|.....:..:|.|.|    .....|||:..
Human  1179 INLQDKNLMAQLQETMRCVCRFDNRTCRKLLASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERL 1243

  Fly    82 VEQQVRKPSDKEQDNLGTLQKKKFTAVLQKTLQAGAQKITQQRGHVPDPTEGQFLLQLRQLRIPD 146
            :::.:|   |||..|      :.||.|..:.|....:|..:           :|:...::|...|
Human  1244 LQRVLR---DKEVAN------RYFTTVCVRLLLESKEKKIR-----------EFIQDFQKLTAAD 1288

  Fly   147 DGKRKLKLEIQRLDSDIRKYMNGNGGKNINELSDLVQNAYTKVSDIVHNDPSFEIATNEDRDSAI 211
            |                          ...::.|.:|..|..::    .|..::.|:.|....|.
Human  1289 D--------------------------KTAQVEDFLQFLYGAMA----QDVIWQNASEEQLQDAQ 1323

  Fly   212 DFFEKVVMTQNHKFLFSPYFTTDEDSDV----KVQKRIRQLS-WITAKHLDCSIDEVNSEARDLV 271
            ...|:.||.:..|..|.|    ::|.|:    .:.:.|::|| .:||.|....|.||  ..|:..
Human  1324 LAIERSVMNRIFKLAFYP----NQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEV--YLREAP 1382

  Fly   272 Y-NAISELVGIDSYYSPQEKLQCTWRCCRHIFELLKRAT-GGPASADDFLPALIFVVLKANPVRL 334
            : :|.||:..|.:|.:|::|:||..|.|..|..||..|. .....||||:|.|:||::||||..|
Human  1383 WPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCL 1447

  Fly   335 HSNINFVTRFTNASRLMSGESGYYFTNLCSAIAFIENLN 373
            .|.:.:::.|  .:..:|||..|::....:|:.||:.::
Human  1448 LSTVQYISSF--YASCLSGEESYWWMQFTAAVEFIKTID 1484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rabex-5	NP_612093.1	zf-A20	17..40	CDD:280010	9/68 (13%)
Rabex-5	NP_612093.1	VPS9	274..373	CDD:280383	37/99 (37%)
GAPVD1	NP_056450.2	RasGAP_RAP6	84..449	CDD:213331
		DUF5601	1272..1335	CDD:407982	15/103 (15%)
		VPS9	1383..1484	CDD:366977	37/102 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D944088at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920