DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rabex-5 and rabx-5

DIOPT Version :9

Sequence 1:	NP_612093.1	Gene:	Rabex-5 / 38144	FlyBaseID:	FBgn0262937	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_001360492.1	Gene:	rabx-5 / 176481	WormBaseID:	WBGene00012644	Length:	520	Species:	Caenorhabditis elegans

Alignment Length:	599	Identity:	153/599 - (25%)
Similarity:	252/599 - (42%)	Gaps:	157/599 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LRLGQQDLKCRSGCGFYGTPQNEGLCSMCFRE------------------KFNDKQRKLKQT--- 53
            :.|...||.|.:|||||||||.|..||.|:|.                  .|:..|.:.|.|
Worm    14 MHLKANDLLCVNGCGFYGTPQWENRCSKCWRAHQNEMKKCQDFAKNRSLLSFDQFQERRKSTTES 78

  Fly    54 ----------------GGETGPGSSSSVATLDRRSPQHAHLQGKVEQQVRKPSDKEQDNLGTLQK 102
                            ||.:.|.|:|..:|..|.|          .::...|...|       .:
Worm    79 KSRGIKNLFKTSPIPEGGTSSPTSTSPASTPTRHS----------RRRELSPDSLE-------AR 126

  Fly   103 KKFTAVLQKTLQAG-AQKITQQRGHVPDPTEGQFLLQLRQLRIPDDGKRKLKLEIQRLDSDIRKY 166
            ::||..|...|..| ||:|.:...:..:                       |:...|:.||
Worm   127 QQFTDFLVANLSTGMAQEIARSVKNAVN-----------------------KISEMRMSSD---- 164

  Fly   167 MNGNGGKNINELSDLVQNAYTKVSDIVHNDPSFEIATNEDR-DSAIDFFEKVVMTQNHKFLFSPY 230
                      ::|:||.:.|..:.:.:.....|:....:.: :..:|..||.:.|    |.:|.:
Worm   165 ----------DMSELVMSYYQYLGERIGGHSLFDSPDCKVKVEDVMDQVEKYIST----FCYSIF 215

  Fly   231 FTT---DEDSDVKVQKRIRQLSWITAKHLDCSIDEVNSEARDLVYNAISELVGIDSYYSPQEKLQ 292
            |..   :|.:|:.:|.|||.|.|:||..|:..:.......||.:..|||||:.|::..|..|||.
Worm   216 FCANHEEEVADMSLQDRIRSLHWVTAGFLETKMVFKKQTVRDKIDEAISELIEINAKRSAFEKLD 280

  Fly   293 CTWRCCRHIFELLKRATGGPASADDFLPALIFVVLKANPVRLHSNINFVTRFTNASRLMSGESGY 357
            |..:.|:.|||.||.:... .|||:|||.||:|:.:.||..:.||:.|::||...:||||||:.|
Worm   281 CLTKSCKAIFEALKESEAS-TSADEFLPTLIYVLFRGNPPLIQSNVKFISRFAIPARLMSGEAAY 344

  Fly   358 YFTNLCSAIAFIENLNGESLGVSSEEFEALMSGQQPYSTPWESALLAC-ESLHLISENMKRMEML 421
            :||||..|:.|..|:|.|||.:...||||..||.  .:.|......|| ::::::...::.:..:
Worm   345 FFTNLSCALEFARNMNHESLQMEKSEFEAYTSGH--LAPPLSVINSACNQAIYVLEGTIETITNV 407

  Fly   422 QKRNALISSGITSFE--------------KELIDF--QREVTERVDTVIAKAPLNLLPIKTPAFL 470
            .|:...::..:|:..              ||.:||  ..|......::.|:..      :|...|
Worm   408 AKKAGSLAKNLTNMHGKSDDDLEKMLAVIKETVDFYPTDEYMNMKQSIFAEEK------ETADIL 466

  Fly   471 IGQARAHLLNESEAGHYQANMLHGGSLTSQSLTAAGGLVKPAAASKESGL------SLKDTSMSS 529
            :..:|    ..||:|.        |:||.         .:|:....::.|      .::..:::|
Worm   467 VSLSR----QSSESGR--------GTLTD---------TQPSTPQPDTSLESPLIAEIQAINLTS 510

  Fly   530 MGRLSPLQQNVQPA 543
            .|.    |::|:.|
Worm   511 SGN----QEHVEEA 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rabex-5	NP_612093.1	zf-A20	17..40	CDD:280010	15/22 (68%)
Rabex-5	NP_612093.1	VPS9	274..373	CDD:280383	47/98 (48%)
rabx-5	NP_001360492.1	zf-A20	21..44	CDD:366793	15/22 (68%)
		DUF5601	147..212	CDD:375592	14/105 (13%)
		VPS9	259..361	CDD:366977	47/102 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164600
Domainoid	1	1.000	95	1.000	Domainoid score	I4658
eggNOG	1	0.900	-	-		E1_KOG3173
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8720
Inparanoid	1	1.050	165	1.000	Inparanoid score	I2812
Isobase	1	0.950	-	0	Normalized mean entropy	S3044
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D320193at33208
OrthoFinder	1	1.000	-	-		FOG0002652
OrthoInspector	1	1.000	-	-		oto20800
orthoMCL	1	0.900	-	-		OOG6_102142
Panther	1	1.100	-	-	LDO	PTHR23101
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1663
SonicParanoid	1	1.000	-	-		X2025
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740