DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rabex-5 and LOC100498468

DIOPT Version :9

Sequence 1:	NP_612093.1	Gene:	Rabex-5 / 38144	FlyBaseID:	FBgn0262937	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	XP_031747412.1	Gene:	LOC100498468 / 100498468	-ID:	-	Length:	477	Species:	Xenopus tropicalis

Alignment Length:	472	Identity:	142/472 - (30%)
Similarity:	228/472 - (48%)	Gaps:	77/472 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 CRSGCGFYGTPQNEGLCSMCFREKFNDKQRKLKQTGGETGP---GSSSSVATLDRRSPQHAHLQG 80
            ||..||:||.|...|.||.|:   .:::|::      :|.|   |......||..:|
Frog    47 CRKNCGYYGNPAWHGYCSRCW---IHERQKR------QTSPLTDGFRHHTGTLFMKS-------- 94

  Fly    81 KVEQQVRKPSDKEQDNLGTLQKKKFTA--VLQKTLQAGAQKITQQRGHVP------DP------- 130
                        |::|...|.:.:.||  |...|....||.......:.|      ||
Frog    95 ------------ERENTSDLGQNENTARVVTINTDTMYAQHSQSSYRYFPTTDVTADPRCFIPWS 147

  Fly   131 -----TEGQFLLQLRQLRIPDDGKRKLKLEIQRLDSD----IRKYMNGNGGKNI--NELSDLVQN 184
                 .:..|...|:.||.|         |.|:|::.    |::..|   .||:  |.:.:.:|:
Frog   148 SLESMAKRDFSDFLKALRRP---------EAQQLNAQCTNLIQRLQN---AKNLTPNTMGEQIQD 200

  Fly   185 AYTKVSDIVHNDPSFEIATNEDRDSAIDFFEKVVMTQNHKFLFSPYFTTDEDSDVKVQKRIRQLS 249
            .|.:::|      .|.....|:|...:|..||:|||:.::.:|....:|||..|:.:|:||:.|.
Frog   201 FYHRIAD------QFPDHMTEERGYFLDNIEKLVMTRLYRSVFCLDGSTDEQKDLLLQRRIKSLK 259

  Fly   250 WITAKHLDCSIDEVNSEARDLVYNAISELVGIDSYYSPQEKLQCTWRCCRHIFELLKRATGGPAS 314
            |:|.|.|...:||...|.:|...:|::.::.:||..:||:||.|..|....:|:.::.:...||:
Frog   260 WVTPKMLQVPLDETIVEVKDWTLSAVTAMLEMDSRRAPQDKLTCVSRASNCLFKSIRASKKDPAT 324

  Fly   315 ADDFLPALIFVVLKANPVRLHSNINFVTRFTNASRLMSGESGYYFTNLCSAIAFIENLNGESLGV 379
            |||||..||::.|:|||.||.||:.::|||.|..||.:||.||.|||||.|::|||||:..||.:
Frog   325 ADDFLSCLIYITLRANPPRLFSNLEYLTRFCNPVRLTTGEWGYCFTNLCCAVSFIENLDASSLSL 389

  Fly   380 SSEEFEALMSGQQPYSTPWESALLACESLHLISENMKRMEMLQKRNALISSGITSFEKELIDFQR 444
            :.|||:.||. |.......::::....:|..:..|.|.:..||.|...:.......||||..:.:
Frog   390 TQEEFDCLMK-QHKTELSTQNSVAQQSTLQQMQHNKKLLAELQHRQDNLIQRAEVLEKELRAWPQ 453

  Fly   445 EVTERVDTVIAKAPLNL 461
            .:...|..:|.:.||::
Frog   454 LIHGEVKEIIRRYPLDI 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rabex-5	NP_612093.1	zf-A20	17..40	CDD:280010	11/20 (55%)
Rabex-5	NP_612093.1	VPS9	274..373	CDD:280383	47/98 (48%)
LOC100498468	XP_031747412.1	zf-A20	46..67	CDD:396357	10/19 (53%)
		DUF5601	175..233	CDD:407982	17/66 (26%)
		VPS9	283..383	CDD:366977	47/99 (47%)
		Lebercilin	399..>462	CDD:406132	12/63 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5190
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3117
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D320193at33208
OrthoFinder	1	1.000	-	-		FOG0002652
OrthoInspector	1	1.000	-	-		otm47608
Panther	1	1.100	-	-	O	PTHR23101
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2025
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.070