DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rabex-5 and rin1

DIOPT Version :9

Sequence 1:	NP_612093.1	Gene:	Rabex-5 / 38144	FlyBaseID:	FBgn0262937	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	XP_031756551.1	Gene:	rin1 / 100495483	XenbaseID:	XB-GENE-493062	Length:	886	Species:	Xenopus tropicalis

Alignment Length:	526	Identity:	108/526 - (20%)
Similarity:	186/526 - (35%)	Gaps:	183/526 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PSLRLGQQDLKCRSGCGFYGTPQNEGLCSMCF--------------REKFNDKQRKLKQTGGETG 58
            |||:. :..|:..||.|       ||  ::||              |.:|   ||.:|.......
Frog   289 PSLKT-RSPLEVSSGGG-------EG--ALCFFNPLFKPKVSGALKRSQF---QRSIKVRVSTEN 340

  Fly    59 PGSSS---------------SVATLDRRSPQHAHLQGKVE-------QQVRKPSDKEQDNLGTLQ 101
            .||.|               .....:|.:|..|..:.:||       |..|||.       .:|:
Frog   341 SGSLSPPINPPPPVPSQEVVKEEEEERIAPLLASQEAEVEQCQLSSDQNYRKPR-------SSLR 398

  Fly   102 KKKFTAVLQKTLQAGAQ----KITQQRG------HVPDP-TEGQFLLQLRQ--------LRIPDD 147
            ::     |:|:|..|:.    ||:|.|.      .||.| |..|...::.|        :.:.|.
Frog   399 QR-----LKKSLSKGSMELGLKISQLRSTDGGDYKVPVPLTRTQESKEIEQSSSNGLSPVEVQDS 458

  Fly   148 G-----------------------------------------------KRKLKLEIQRLDSDIRK 165
            |                                               :||:.:.|:.:..||:.
Frog   459 GSSSSEEGTSEDFGKFSPQLTRRRKIKKKSGRSSFRAVSGAFLSLLSPERKVLMFIEEMSRDIQT 523

  Fly   166 YMNGNGGKNINELSDLVQNAYT------KVSDIVHNDPSFEIATNEDRDSAIDFFEKV--VMTQN 222
            ..    ||   ||.|.::....      |..|....:.|::....|.|    ||.:||  |:.::
Frog   524 EF----GK---ELQDFLRRVTDGESMGGKEKDTEDEEGSYKTLLKEVR----DFMDKVKHVLRES 577

  Fly   223 HKFLFSPYFTTDEDSDVKVQKRIRQ--LSWITAKHLDCSIDEVNSEARDL---------VYNAIS 276
            .:.....  .:.|:.|..::|.:.:  |..:.| ||...|.:...|:.||         |.|:.|
Frog   578 AELQLET--LSLEEQDRVLEKSLHRLILKPLNA-HLVSVIHKGVEESGDLERLGKNMQAVKNSGS 639

  Fly   277 ELVGI--------------------DSYYSPQEKLQCTWRCCRHIFELLKRATGGPASADDFLPA 321
            .|:|:                    ...|||.:|::...:.||.::..:.........||:||||
Frog   640 SLLGVSLMAPTAPELEKIRHKLLRMQEKYSPTDKVRLLLQACRLVYRNIDAQQDDACGADEFLPA 704

  Fly   322 LIFVVLKANPVRLHSNINFVTRFTNASRLMSGESGYYFTNLCSAIAFIENLNGE--SLGVSSEEF 384
            |.:|:...:..:|..:..:.........|: ||.|||.|::.::::.:.:|:..  .:|:|..|:
Frog   705 LCYVLALCDLPQLLIHTYYTGELLPQDTLV-GEGGYYLTSVSASLSVLSSLHTHPPDMGLSLSEW 768

  Fly   385 EALMSG 390
            .....|
Frog   769 HRKRQG 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rabex-5	NP_612093.1	zf-A20	17..40	CDD:280010	8/36 (22%)
Rabex-5	NP_612093.1	VPS9	274..373	CDD:280383	25/118 (21%)
rin1	XP_031756551.1	SH2_RIN1	118..218	CDD:198256
		VPS9	654..742	CDD:366977	21/88 (24%)
		RA_Rin1	782..869	CDD:340735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910