DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rabex-5 and zfand4

DIOPT Version :9

Sequence 1:	NP_612093.1	Gene:	Rabex-5 / 38144	FlyBaseID:	FBgn0262937	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_001189400.1	Gene:	zfand4 / 100148477	ZFINID:	ZDB-GENE-090312-102	Length:	673	Species:	Danio rerio

Alignment Length:	432	Identity:	96/432 - (22%)
Similarity:	155/432 - (35%)	Gaps:	105/432 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KQRKLKQTGGETGPGSSSSVATLDRRSPQHAHLQGKVEQQVRKPSDKEQDNLGTLQKKKFTAVLQ 110
            |..||| .....||...|.    ...|.:| |...:|..|:...|......:|..|:.     :.
Zfish   225 KTAKLK-IRPPVGPRPCSG----SHGSARH-HRMFRVLPQIGHASSTHLPPIGDQQQP-----VL 278

  Fly   111 KTLQAG---------AQKITQQRGHVPDPTEGQFLLQLRQLRIPDDG--KRKLKL--EIQRLDSD 162
            .|..||         :...:..|.|......|.::||..:   |.|.  .||::|  ::.|||..
Zfish   279 STPTAGSAHQPYTSLSSPASSSRAHPSSAASGIYMLQAEE---PWDNPVPRKIRLPPKVSRLDMR 340

  Fly   163 IRKYMNGNGGKNINELSDLVQNAYTKVSDIVHNDPSFEIATNEDRDSAIDF-FEKVVMTQNHKFL 226
            ..|.|.                      |.|:  |...:.::......:|. .|.:.:|:....:
Zfish   341 GPKVMR----------------------DCVY--PPLSLLSSPGVQDEVDIKNEHLTLTEKTTVI 381

  Fly   227 FSPY---FTTDE--DSDVKVQKRIRQLSWITAKHLDCSIDEVNSEARDLVYNAISELVGIDSYYS 286
            .||.   |...|  ..||..| |.|.|:.:|       :.|.|:.|     ..:|:.|..:....
Zfish   382 ESPKAVPFNLPEPLSLDVSAQ-RERSLNSLT-------MPEANAAA-----PLLSQAVNSNWRLP 433

  Fly   287 PQEKLQCT---WRCCRHIFELLKRATGGPASADDFLPALIFVVLKANP-VRLHSNINFVTRFTNA 347
            .|..|..|   :...|| ||.    ||....     |:....:|:.:| :.:.|......:....
Zfish   434 SQHDLTLTTEPFTPPRH-FEF----TGSSVH-----PSPSHALLRTSPSLPISSPSKTTFKVDKH 488

  Fly   348 SRLMSGESGYYFTNLCSAIAFIENLNGESLG-VSSEEFEALMS---GQQPYSTPWESALLAC--- 405
            |.::|.......|||.:      ....|.|| ||:.|..|.::   ||:..::|:....|..
Zfish   489 SEVISKSEARDITNLAN------KATKEPLGSVSNAELLASLAGSGGQETLTSPYALGRLCATAA 547

  Fly   406 ---ESLHLISEN-MKRMEMLQKRNALI----SSGITSFEKEL 439
               .::||:.|: ::|:..||:.....    |||::|..|.|
Zfish   548 PLPNNIHLLQEDLLRRISPLQRTAGFTASSSSSGLSSSIKRL 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rabex-5	NP_612093.1	zf-A20	17..40	CDD:280010
Rabex-5	NP_612093.1	VPS9	274..373	CDD:280383	20/102 (20%)
zfand4	NP_001189400.1	AN1_N	1..103	CDD:176397
		UBQ	28..99	CDD:214563
		ZnF_AN1	613..651	CDD:197545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3173
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900