Protein Alignment CG32333 and Fam135b

DIOPT Version :10

• Sequence 1: NP_001261246.1
• Gene: CG32333 / 38142
• FlyBaseID: FBgn0052333
• Length: 1499
• Species: Drosophila melanogaster
• Sequence 2: NP_808487.2
• Gene: Fam135b / 70363
• MGIID: 1917613
• Length: 1403
• Species: Mus musculus
• Alignment Length: 1709
• Identity: 516/1709 - (30%)
• Similarity: 733/1709 - (42%)
• Gaps: 518/1709 - (30%)

  Fly     1 MGDLQATIEFVVELHKFFNVDLFQRGLYQVRCGLRVSPRLLVQVETSIPEASGPGKQNGHANGAN 65
            |.::|.|:||.||||||:||||||||.||:|..|:||.|:..::..||.
Mouse     1 MSEVQGTVEFSVELHKFYNVDLFQRGYYQIRVTLKVSSRIPHRLSASIV---------------- 49

  Fly    66 ATDHGSSDSERGELSPGEVPRLHESPPGGSCSSASVINGSGASRIFQILYRNEEVPLRDIIHFRS 130
                |.|:|                   .|..||.|...:..||:||||||||||.:.|.:.||.
Mouse    50 ----GQSES-------------------SSLHSACVHESAVHSRVFQILYRNEEVSINDAMLFRV 91

  Fly   131 HLLVDSRHLKESIERAEFSLQLELWF--GEQNGSSSLNGNGGGSGMGSFSGPASSALTLASTRNL 193
            |||:|...:::::...||.|:::|.|  .||.             :...:|     ..:.|:|.|
Mouse    92 HLLLDGERVEDALSEVEFQLKVDLHFTDSEQQ-------------LRDVTG-----TPMISSRTL 138

  Fly   194 QLNFHPGRGLHYHLPVLFDYFHLAAISVGIHASLVALHQPYIKKSVFSYMKFCAP-RSSKPWSAG 257
            .|:|||.||||:.:||:||||||:.|||.|||:||||.||.|        .|..| |.|  | .|
Mouse   139 GLHFHPRRGLHHQVPVMFDYFHLSVISVAIHAALVALQQPLI--------SFTRPGRGS--W-LG 192

  Fly   258 KLSCRGNTSPGP------LEAVFFGPQIGGTTKCSGG---PAGRLLQ-SRAIHREICSLLLGAIE 312
            |    |....||      ||.:.||......|...|.   |:...:| :...||::|.|||.|.:
Mouse   193 K----GGPDTGPEQPTISLENLVFGAGYCKPTSSEGSFYVPSENCIQHAHKWHRDLCLLLLHAYQ 253

  Fly   313 QLKATLNEFSTVLPPSINSQIGSPPLRENDTGERLQLLLDQAKQLEAEEDFAIRANSDIAQLCAE 377
            .|:.........:|     ::.:..|......|.|..|..:.:.|...|..|.:.:.|:|.|.:.
Mouse   254 GLRLYFLVIMRDIP-----ELPTMELEALAVEETLSQLCSELQMLNNPEKIAEQISKDLAWLASH 313

  Fly   378 SIFWWRRVLLASRSSTAVHTLLARKHHILRVRRFAEGFFVLEQPRHAAAAGCPDQTNGSPSPGHC 442
            .:..|.:.|......:.|.|.|.::||.||||||:|.||.:|   |...|....|.|...:  |.
Mouse   314 LMALWTQFLDTVTLHSQVTTYLTQEHHTLRVRRFSEAFFYME---HQKLAVLTFQENLIQT--HS 373

  Fly   443 QGYVAIAELARRSRYLQSLPPLPVHCTPIDGDASSLPLIFEDRYVTTNSTYARRRSGSDPQLEDA 507
            |..:.|    |.|.||.|:||||..|..||||.::||:|||||||
Mouse   374 QLSLDI----RNSEYLTSMPPLPAECLDIDGDWNTLPVIFEDRYV-------------------- 414

  Fly   508 VSVVGVQKKKVDKTHSSSSLNGIKDC------LACHFDYDYPQTNGSGPAHPHAKCVITPRFALG 566
                                    ||      |:.:.::|.|.|:   ||..:.|         |
Mouse   415 ------------------------DCPVSGHNLSVYPNFDVPVTS---PAIMNLK---------G 443

  Fly   567 GEV------------LQASLTIAPSKEAAPEAVAPPTLRHNLSRHSVTGLLEDLDLDSSLPARHS 619
            .|.            :..|.|.||...:..:....|.::.|:|
Mouse   444 KEKNLINQNSSSRKDIPLSTTEAPQLGSDEDVTRRPEVQENVS---------------------- 486

  Fly   620 KSLDQLDGCEGLATNPVSTTNNHTLPRLQADDLMRNICEFRQRY---GKFDYLHEIKLLNPPKQQ 681
                        ..||:                  ::|...|.|   |:|             |.
Mouse   487 ------------TWNPI------------------DVCSESQVYLTIGEF-------------QN 508

  Fly   682 QQAVPQQQQQCNNG------YNSLPKSMVPPRNSYPPPPPSQHTTMP----RSSSSQIPRAVEIA 736
            :..:|  :.:|..|      .:||..:.:..|:  |.|...|...:.    :||:...|||..:.
Mouse   509 RAGIP--EDECWTGPRPDAVKDSLTDTDICSRS--PGPDEGQTPALTYIDVQSSNKYCPRAELVQ 569

  Fly   737 RVRVSDIKEMLRQGQLRKESSSSESDMMQKLQMLSSNSVPFR-LEGTSNNNTTS----------- 789
            .:.|.           .:..||.||..:.|       :||.: :.|||.||:||
Mouse   570 GINVQ-----------HEHRSSRESYGIVK-------TVPSKVVAGTSQNNSTSLNQTAALELRT 616

  Fly   790 -----------------------SDPNTSGFSESL------PNLAPPPEFDSDSQLRRQRSNSTS 825
                                   .||.::...|:|      |:.|..||
Mouse   617 LGRGVNQDGKPVLLSLKLTPAEPCDPPSTALREALDTKPSQPDHAEEPE---------------- 665

  Fly   826 SLSEESGWVSSRRSSLAISSPDTITSTGMTNRQRHTQLNLGMGMAMETRLNGEQLRLRLQKVLEQ 890
            .||..|| |..|.:|:       |:.:|:.:.......:.....|:|...:.:.|
Mouse   666 DLSALSG-VIKRSASI-------ISDSGIESEPSSVAWSEARSRALELPSDRDVL---------- 712

  Fly   891 QQLQQQHPHKNRKRQAG-TSSQSRTPARQQTEVHKKISSVTV-NIKRERSRYQLDRLRHLPNGES 953
            .|:.::|.|.....:.| |.|.:..|:..|..: ..|||:.. ..:||.:..:|.:....|...|
Mouse   713 HQVVRRHAHHRNSLEGGHTESNTSLPSGIQASL-SSISSLPFEEEERELALNKLTKSVSAPQISS 776

  Fly   954 TE---------------VEEMEPPPRRN---RHKTACEKSKSDFDIT---SLKDMQPLDAVCLPP 997
            .|               .|:::|..:.|   ||.:.........|:.   ||.|: .||:
Mouse   777 PEESAEGADTIKNTAGFSEDLDPSSKENSPPRHTSLSYGGSRVQDVRAGHSLADI-ALDS----- 835

  Fly   998 PQQFQDQEQELALVLAPP----PPDEFRDPP-PEPAPAAPIAPVPPPAAALPPTGKTKIVACHLP 1057
                 |:.|      .|.    |.|:...|. .||.....:|..|...       :||.:...:|
Mouse   836 -----DRPQ------GPGYMDIPNDKGNHPELQEPCCLDGMAETPLHV-------ETKGLNLKIP 882

  Fly  1058 PPL-----KERQPIGAIDNPVYHIYESLRPISTPAIFS-NKPVLKSHSLAELKRPQNLPNHSINH 1116
            ..:     |.|.         :|..........|...| :|.||.::|::|::        :.:|
Mouse   883 CTIVLENSKSRS---------FHRAAGETAKGKPEELSMSKCVLSNNSISEVR--------AASH 930

  Fly  1117 H------CK--THAINANGNVLENG-------------------LDHEQDEI----------KEN 1144
            |      |.  ..|:|.|...::|.                   ..||...:          :.:
Mouse   931 HRVPEISCSPAVEAVNLNSTGVQNSSLSVNDTMTLNRRHNASLEAKHEAGTVCPTVTHTIASQVS 995

  Fly  1145 SNGQVRTNKQGHGSNTNS----------------------------------------------- 1162
            .|.:::|.....||:.||
Mouse   996 RNQELKTGTSISGSHLNSTEAFTLDSLKAVEVVNLSVSCTATCLPFSSVPKETPARAGLSSKQNP 1060

  Fly  1163 ---KHKRKGQLA-----SAVQEAPPSISLLEFEKYREEFRKQIKYQGSIYSDYVQLASELPYFYI 1219
               .|:..|...     |:..|...|..:..|.:.:|:|:|::|.:|.:|||...|||::|||..
Mouse  1061 APITHQPLGSFGVVSTYSSKLEEEVSERMFSFYQAKEKFKKELKIEGFLYSDLSVLASDIPYFPP 1125

  Fly  1220 SDEYRAFSPNGMHLVICVHGLDGNSADLRLVRTYLELGLPGVNLEFLMSERNQGDTFSDFDTMTD 1284
            .:|..... :|:|||:|||||||||||||||:|::||||||..|:|||||:||.|||:|||||||
Mouse  1126 EEEEENLE-DGIHLVVCVHGLDGNSADLRLVKTFIELGLPGGKLDFLMSEKNQTDTFADFDTMTD 1189

  Fly  1285 RLVTEILYHIDSCALNPARISFVAHSLGTIIVRSALARPQMRPLLPRLHTFLSLSGPHLGTLYNT 1349
            ||:.||:.||....|:.:||||:.||||.||:||.|.||:.|..|.:|||||||||||||||||.
Mouse  1190 RLLDEIIQHIQLYNLSISRISFIGHSLGNIIIRSVLTRPRFRYYLNKLHTFLSLSGPHLGTLYNN 1254

  Fly  1350 SGLVNMGMWFMQKWKKSGSLLQLCMRDTTDMRNSFLYRLSQRSTLHHFKNILLCGSSQDRYVPAH 1414
            |.||:.|:|.|||.|||||||||..||..|:|..|||:|||::.|.:|||::|..|.||||||.|
Mouse  1255 STLVSTGLWLMQKLKKSGSLLQLTFRDNADLRKCFLYQLSQKTGLQYFKNVVLVASPQDRYVPFH 1319

  Fly  1415 SARLELCKAAMRDSSSLGTIYREMVHNIIAPILARPELTLARFDVHHALPHTANTLIGRAAHIAV 1479
            |||:|:||.|::|..: |.:|.||::|::.|::...:.||.|.:|.||||:||||||||||||||
Mouse  1320 SARIEMCKTALKDRHT-GPVYAEMINNLLGPLVEAKDCTLIRHNVFHALPNTANTLIGRAAHIAV 1383

  Fly  1480 LDSELFIEKFMLIAGLKYF 1498
            ||||||:|||.|:|||.||
Mouse  1384 LDSELFLEKFFLVAGLNYF 1402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32333	NP_001261246.1	DUF3657	150..227	CDD:463558	31/78 (40%)
		DUF676	1227..1422	CDD:309968	129/194 (66%)
Fam135b	NP_808487.2	DUF3657	111..172	CDD:463558	31/78 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	445..483		6/37 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	514..548		8/35 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	648..669		7/36 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	718..740		6/21 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	790..819		5/28 (18%)
		DUF676	1133..1327	CDD:309968	129/194 (66%)