DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32333 and Fam135a

DIOPT Version :9

Sequence 1:	NP_001261246.1	Gene:	CG32333 / 38142	FlyBaseID:	FBgn0052333	Length:	1499	Species:	Drosophila melanogaster
Sequence 2:	XP_006496292.1	Gene:	Fam135a / 68187	MGIID:	1915437	Length:	1536	Species:	Mus musculus

Alignment Length:	1722	Identity:	494/1722 - (28%)
Similarity:	742/1722 - (43%)	Gaps:	469/1722 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 YQVRCGLRVSPRLLVQVETSIPEASGPGKQNGHANGANATDHGSSDSERGELSPGEVPRLHESPP 92
            ||:|..:::..|:..:||.|:.          ||.|...
Mouse    32 YQIRASMKIPARIPHRVEASLL----------HATGMTL-------------------------- 60

  Fly    93 GGSCSSASVINGSGASRIFQILYRNEEVPLRDIIHFRSHLLVDSRHLKESIERAEFSLQLELWFG 157
               ...|||.:....|:.|||||:||||.|.|::.|:..:|:|.|.::|::|...|.|.|.|.|.
Mouse    61 ---AFPASVHDALVCSKTFQILYKNEEVVLNDVMIFKVKMLLDERKIEETLEEISFLLSLGLHFT 122

  Fly   158 EQNGSSSLNGNGGGSGMGSFSGPASSALTLASTRNLQLNFHPGRGLHYHLPVLFDYFHLAAISVG 222
            :                |.:|....:||.|.|:|.|:|::...||||:|..|:||||||:.:||.
Mouse   123 D----------------GDYSADDLNALQLISSRTLKLHYSICRGLHHHANVMFDYFHLSVVSVT 171

  Fly   223 IHASLVALHQPYIKKSVFSYMKFCAPRSSK-PWSAGKLSCRGNTSPGP-LEAVFFGPQIGGTTKC 285
            :||||||||||.|.          .||..| .|.......:...|..| ||:|.||  |..|.:.
Mouse   172 VHASLVALHQPLIS----------FPRPVKTTWLNRNAPAQSKDSAIPTLESVVFG--INYTKQL 224

  Fly   286 SGGPAGRLLQSRAIHR------EICSLLLGAIEQLKATLNEFSTVLPPSINSQIG---------- 334
            |......|:....:|.      .:|:.||.|.:.|.:.....:..:|......:.
Mouse   225 SPDGCSFLIAESFLHHAYHFHYTLCATLLLAFKGLHSYFITVTEEIPSCQKLDLAKASMQVLYER 289

  Fly   335 ----SPPLRENDT-------GERLQLLLDQAKQLEAEEDFAIRANSDIAQLCAESIFWWRRVLLA 388
                :.|..:|||       ..||..|.::.|::|..::.|...|.::||||:..:..|.:.|.|
Mouse   290 LLRRTQPRTQNDTCLEEMDVEARLTELCEEVKKVENPDELAELINMNLAQLCSLLMALWGQFLEA 354

  Fly   389 SRSSTAVHTLLARKHHILRVRRFAEGFFVLEQPRHAAAAGCPDQTNGSPSPGHCQGYVAIAELAR 453
            ......:..|||::||.||||||:|.||..|.||.||.|         ....|.|.::.:....:
Mouse   355 ITLHEDLRVLLAQEHHTLRVRRFSEAFFCFEHPREAAIA---------YQELHAQSHLQMCTAIK 410

  Fly   454 RSRYLQSLPPLPVHCTPIDGDASSLPLIFEDRYVTTNSTYARRRSGSDPQLEDA-VSVVGVQKKK 517
            .:.:..||||||:.|:.:|||.:|||:||||||:             |..:||. ...:|:|..:
Mouse   411 NTSFCSSLPPLPIECSELDGDLNSLPIIFEDRYL-------------DSVIEDLDAPWMGIQSLQ 462

  Fly   518 VDKTHSSSSLNGIKDCLACHFDYDYPQTNGSGPAHPHAKCVITPRFALGGEVLQASLTIAPSKEA 582
            :.:...:..             ::..:::..|.:.|..|  :.|..|......:....:..|.:.
Mouse   463 ISEASKTDK-------------HETEESSVVGLSSPELK--VRPAVASSNCYTEGEKQLTKSLKG 512

  Fly   583 APEAVAPPTLRHNLSRHSVTGLLEDLDLDSS--LPARHSKSLDQLDGCEGLATNPVST------- 638
            ..|       ..|.|:..||.|::.:..:::  |..::||....|...:.|.|...|.
Mouse   513 KNE-------ESNKSKVKVTKLMKTMKPENTKKLIKQNSKDSVVLVSYKCLKTTASSDFTKCLEG 570

  Fly   639 TNNHTLPRLQADDLMRNICEFRQRYGKFD---YLHEIKLLNPPKQQQQA---------------- 684
            :.:|:    |.:.|...:|.     |.||   |..:      |.|::.:
Mouse   571 SPSHS----QKEGLDPTLCA-----GNFDPKTYTRQ------PSQKEASSLSANTDRSEHKSPDT 620

  Fly   685 ---VPQQQQQCNNGYNSL-------PKSMVPPRNSYPPPPPSQHTTMPRSSSSQIP--RAVEIAR 737
               .|.|.:..|:|..:|       .|..:...||  ..|.::|.....|||:...  :....:.
Mouse   621 ENMQPDQFELLNSGSLNLCANLSISGKLAISQDNS--DIPDTEHNLASTSSSNDCHDYQTTPSSG 683

  Fly   738 VRVSDIKEMLRQGQLRKESSSSE-------------------SDMMQKLQMLSSN------SVPF 777
            ||..::|..      .|||.:.|                   .:::...:.|.||      .:|.
Mouse   684 VRTLEVKSS------SKESFNGEKITVKIGPWTELQEAELFVDNLLPDFEALDSNDKPKSIDIPL 742

  Fly   778 RLEGTSNNNTTSSDPNTSGFSESLPNLAP-PPEFD---SDSQLRRQRSNST--SSLSEESGWVSS 836
            ..:........|::.:.:.|..:||  || ..|:.   |...::...:|:|  ||...:|| |.|
Mouse   743 ERDALQETKCHSTEESLTKFRSNLP--APSTKEYHVAVSSDTIKLPDTNATYASSRFSDSG-VES 804

  Fly   837 RRSSLAI-SSP----DTITSTGMTNRQRHTQLNLGMGMAMETRLNGEQLRLRLQKVLEQQQLQQQ 896
            ..||.|. .:|    :|:...|..|.:|                            |..|.|.:
Mouse   805 EPSSFATHPNPEIAFETLQGPGPCNNER----------------------------LFPQLLMK- 840

  Fly   897 HPHKNRKRQAGTSSQSRTPARQQTEVHKKISSVTVNIKRERSRYQLDRLRHLPNGESTEVEEMEP 961
             |..|.|...|:.....|.|  .:|:...::|:                ..||:.     :|:.|
Mouse   841 -PDHNVKFSLGSHCTESTSA--LSEIQSSLTSI----------------NSLPSD-----DELSP 881

  Fly   962 PPRRNRHKTACEKSK-SDFDITSLKDMQPLDAVCLPPPQQFQD-----QEQELAL-------VLA 1013
            ...       |:||. .|..::..|.:..|..:.||.....:.     |:|.:..       .||
Mouse   882 DDN-------CKKSAVPDCHLSDSKTVFNLGTMDLPKCDDTKKSSIILQQQSVVFSGHLDNDTLA 939

  Fly  1014 PPPPDEFRDPP------PEPAPAAPIAPVPPPAAALPPTGKTKIVACHLPPPLKERQPIGAIDNP 1072
            ....|...:.|      .|.|.:.    |.....:.|          ||..|....|..|...|
Mouse   940 MHSLDLSTEDPLRLVFLDEDASSG----VRSSWGSKP----------HLDAPFTGPQSQGTSSN- 989

  Fly  1073 VYHIYESLRPISTPAIFSNKPVLKSHSL---AELKRPQNLPNHS---INHH--C------KTHAI 1123
              :..||:..:::..|....|.:.|.|:   |.|...:.:...|   :||.  |      ::..:
Mouse   990 --NSTESVPTLNSKLICLGSPCVVSGSVCTDAGLSADRTVEGKSGEPLNHKQVCSAAPVVESDPL 1052

  Fly  1124 NANGNVLENGL------------------------------------DHEQDEIKEN-------- 1144
            :::.:|::.||                                    |.:|::.||.
Mouse  1053 SSSTDVVKQGLVENYFGSQSTTDVSDACAITCHSPVSSQETCDKGISDLQQEQGKEEEEEDQEMV 1117

  Fly  1145 SNG-----------------QVRTNKQGHGSNTNSKHKRKGQLA-----------------SAVQ 1175
            .||                 .:..|:.|.|.:..|:......|:                 ||::
Mouse  1118 QNGYHEETDFSATDGTVSVHYISGNELGEGRHEQSEKLSSNYLSAGVTVPAVCTSGCLSFPSALR 1182

  Fly  1176 EAP----------------------------------PSISLLEFEKYREEFRKQIKYQGSIYSD 1206
            |:|                                  |...:..|.:.:||. ||::..|.:|||
Mouse  1183 ESPCVKYSSRSKVDAITKQPSSISYNFSSSTSWYENSPKPQIHAFLQAKEEL-KQLRLPGFMYSD 1246

  Fly  1207 YVQLASELPYFYISDEYRAFSPNGMHLVICVHGLDGNSADLRLVRTYLELGLPGVNLEFLMSERN 1271
            ...|||..|||.:.:|  ..|.:|:||::|||||||||||||||:||:||||||..::|||||||
Mouse  1247 VPLLASSAPYFSMDEE--DGSEDGVHLIVCVHGLDGNSADLRLVKTYIELGLPGGRVDFLMSERN 1309

  Fly  1272 QGDTFSDFDTMTDRLVTEILYHIDSCALNPARISFVAHSLGTIIVRSALARPQMRPLLPRLHTFL 1336
            |.|||:|||.|||||:.||:.:|...:|..::|||:.||||.:|:||.|.||:.:..|.:|||||
Mouse  1310 QNDTFADFDCMTDRLLDEIIQYIQIYSLTVSKISFIGHSLGNLIIRSVLTRPRFKYYLSKLHTFL 1374

  Fly  1337 SLSGPHLGTLYNTSGLVNMGMWFMQKWKKSGSLLQLCMRDTTDMRNSFLYRLSQRSTLHHFKNIL 1401
            ||||||||||||:|.|||.|:|||||||||||||||..||.:|.|.:|||:||.::.||:|||::
Mouse  1375 SLSGPHLGTLYNSSALVNTGLWFMQKWKKSGSLLQLTCRDHSDPRQTFLYKLSNKAGLHYFKNVV 1439

  Fly  1402 LCGSSQDRYVPAHSARLELCKAAMRDSSSLGTIYREMVHNIIAPILARPELTLARFDVHHALPHT 1466
            |.||.||||||.||||:|:||.|::|..| |.||.||:||::.|:|......|.|::|.:|||:|
Mouse  1440 LVGSLQDRYVPYHSARIEMCKTALKDKQS-GQIYSEMIHNLLRPVLQSKGCNLVRYNVINALPNT 1503

  Fly  1467 ANTLIGRAAHIAVLDSELFIEKFMLIAGLKYF 1498
            |::||||||||||||||:|:|||.|:|.||||
Mouse  1504 ADSLIGRAAHIAVLDSEIFLEKFFLVAALKYF 1535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32333	NP_001261246.1	DUF3657	150..226	CDD:289180	28/75 (37%)
		MhpC	1223..>1447	CDD:223669	142/223 (64%)
		DUF676	1227..1422	CDD:282860	129/194 (66%)
Fam135a	XP_006496292.1	DUF3657	115..175	CDD:372086	28/75 (37%)
Fam135a	XP_006496292.1	DUF676	1265..1460	CDD:309968	129/194 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830693
Domainoid	1	1.000	280	1.000	Domainoid score	I1668
eggNOG	1	0.900	-	-		E1_KOG2205
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	630	1.000	Inparanoid score	I845
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001840
OrthoInspector	1	1.000	-	-		otm43232
orthoMCL	1	0.900	-	-		OOG6_102700
Panther	1	1.100	-	-	O	PTHR12482
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3354
SonicParanoid	1	1.000	-	-		X1527
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780