Protein Alignment CG32333 and FAM135A

DIOPT Version :10

• Sequence 1: NP_001261246.1
• Gene: CG32333 / 38142
• FlyBaseID: FBgn0052333
• Length: 1499
• Species: Drosophila melanogaster
• Sequence 2: NP_001317925.1
• Gene: FAM135A / 57579
• HGNCID: 21084
• Length: 1541
• Species: Homo sapiens
• Alignment Length: 1779
• Identity: 507/1779 - (28%)
• Similarity: 758/1779 - (42%)
• Gaps: 520/1779 - (29%)

  Fly     1 MGDLQATIEFVVELHKFFNVDLFQRGLYQVRCGLRVSPRLLVQVETSIPEASGPGKQNGHANGAN 65
            |.::||.:||.|||:||:||||||||.||:|..:::..|:..:||.|:.          ||.|..
Human     1 MTEVQAMVEFSVELNKFYNVDLFQRGFYQIRASMKIPSRIPHRVEASLL----------HATGMT 55

  Fly    66 ATDHGSSDSERGELSPGEVPRLHESPPGGSCSSASVINGSGASRIFQILYRNEEVPLRDIIHFRS 130
            .                             ...|||.:....|:.|||||:||||.|.|::.|:.
Human    56 L-----------------------------AFPASVHDSLICSKTFQILYKNEEVVLNDVMIFKV 91

  Fly   131 HLLVDSRHLKESIERAEFSLQLELWFGEQNGSSSLNGNGGGSGMGSFSGPASSALTLASTRNLQL 195
            .:|:|.|.::|::|...|.|.|:|.|.:                |.:|....:||.|.|:|.|:|
Human    92 KMLLDERKIEETLEEMNFLLSLDLHFTD----------------GDYSADDLNALQLISSRTLKL 140

  Fly   196 NFHPGRGLHYHLPVLFDYFHLAAISVGIHASLVALHQPYIKKSVFSYMKFCAPRSSK-PWSAGKL 259
            :|.|.||||:|:.|:||||||:.:||.:||||||||||.|.          .||..| .|.....
Human   141 HFSPHRGLHHHVNVMFDYFHLSVVSVTVHASLVALHQPLIS----------FPRPVKTTWLNRNA 195

  Fly   260 SCRGNTSPGP-LEAVFFGPQIGGTTKCSGGPAGRLLQSRAIHR------EICSLLLGAIEQLKAT 317
            ..:...|..| ||:|.||  |..|.:.|......::....:|.      .:|:.||.|.:.|.:.
Human   196 PAQNKDSVIPTLESVVFG--INYTKQLSPDGCSFIIADSFLHHAYRFHYTLCATLLLAFKGLHSY 258

  Fly   318 LNEFSTVLP-------PSINSQI--------------GSPPLRENDTGERLQLLLDQAKQLEAEE 361
            ....:..:|       ...|.|:              ....|.|.|...||..|.::.|::|..:
Human   259 FITVTEEIPSCQKLELAKANMQLLYERLLRRKQLRTQKDNHLEEMDVEARLTELCEEVKKIENPD 323

  Fly   362 DFAIRANSDIAQLCAESIFWWRRVLLASRSSTAVHTLLARKHHILRVRRFAEGFFVLEQPRHAAA 426
            :.|...|.::||||:..:..|.:.|........:..|||::||.||||||:|.||..|.||.||.
Human   324 ELAELINMNLAQLCSLLMALWGQFLEVITLHEELRILLAQEHHTLRVRRFSEAFFCFEHPREAAI 388

  Fly   427 AGCPDQTNGSPSPGHCQGYVAIAELARRSRYLQSLPPLPVHCTPIDGDASSLPLIFEDRYVTTNS 491
            |         ....|.|.::.:....:.:.:..||||||:.|:.:|||.:|||:||||||:
Human   389 A---------YQELHAQSHLQMCTAIKNTSFCSSLPPLPIECSELDGDLNSLPIIFEDRYL---- 440

  Fly   492 TYARRRSGSDPQLEDA-VSVVGVQ------KKKVDKTHSSSSLNGIKDCLACHFDYDYPQTNGSG 549
                     |...||. ...:|:|      ..|:||                   |:..:::.:|
Human   441 ---------DSVTEDLDAPWMGIQNLQRSESSKMDK-------------------YETEESSVAG 477

  Fly   550 PAHPHAKCVITPRFALGGEVLQASLTIAPSKEAAPEAVAPPTLRHNLSRHSVTGLLEDLDLDSS- 613
            .:.|..|  :.|..|       :|:.....::...:::.......|.|:..||.|::.:..:::
Human   478 LSSPELK--VRPAGA-------SSIWYTEGEKQLTKSLKGKNEESNKSKVKVTKLMKTMKSENTK 533

  Fly   614 -LPARHSKSLDQLDGCEGLATNPVSTTNNHTLPRLQADDLMRNICEFRQRYGKFDYLHEIKLLNP 677
             |..::||....|.|.:.|.    ||.:|         ||::  |        |:.       ||
Human   534 KLIKQNSKDSVVLVGYKCLK----STASN---------DLIK--C--------FEG-------NP 568

  Fly   678 PKQQQQAVPQQQQQCNNGYNSLPKSMVPPRNSYPPPPPSQHTTMPRSSSSQIPRAVEIARVRVSD 742
            ...|::.:  ....|  |||..||:.:            :.|:  :..:|.:|...|
Human   569 SHSQKEGL--DPTIC--GYNFDPKTYM------------RQTS--QKEASCLPTNTE-------- 607

  Fly   743 IKEMLRQGQLRKESSSSESDMMQKLQMLSSNSVPFRLEGTSNNNTTSSDPNTSGFSESLPNLAPP 807
                      |.|..|.:.:.:|..|.                     ||..||......||:..
Human   608 ----------RTEQKSPDIENVQPDQF---------------------DPLNSGNLNLCANLSIS 641

  Fly   808 PEFD---SDSQLRRQRSNSTSSLSEESGWVSSRRSSLAISSPDTITSTGM-------TNRQRHTQ 862
            .:.|   .||::.:...|           ::|||||.......|..|.|:       :|:...:.
Human   642 GKLDISQDDSEITQMEHN-----------LASRRSSDDCHDHQTTPSLGVRTIEIKPSNKDPFSG 695

  Fly   863 LNLGMGMAMETRLNGEQLRL-----------------RLQKVLEQQQLQQQHPHKNRKRQAG--- 907
            .|:.:.:...|.|..|::.:                 .::...|::.||:.     :....|
Human   696 ENITVKLGPWTELRQEEILVDNLLPNFESLESNGKSKSIEITFEKEALQEA-----KCLSIGESL 755

  Fly   908 TSSQSRTPARQQTEVHKKISSVTVNIKRERSRYQLDRLRHLPNGESTEVEEMEPPPRRN------ 966
            |..:|..||....|.|..:|..|:.:....:.|...|..  .:|..:|.......|..:
Human   756 TKLRSNLPAPSTKEYHVVVSGDTIKLPDISATYASSRFS--DSGVESEPSSFATHPNTDLVFETV 818

  Fly   967 RHKTACEKS--------KSDFDITSLKDMQPLDAVCLPPPQQFQDQEQELALVLAPPPPDEFRDP 1023
            :.:..|...        |.|:::..     .|...|........:.:..|..:.:.|..||.
Human   819 QGQGPCNSERLFPQLLMKPDYNVKF-----SLGNHCTESTSAISEIQSSLTSINSLPSDDEL--- 875

  Fly  1024 PPEPAPAAPIAP----------VPPPAAALPPTGKTKIVACHLPPPLKERQPI---GAIDNPVYH 1075
            .|:......:.|          :......||....||..:..|     ::|.:   |.:||....
Human   876 SPDENSKKSVVPECHLNDSKTVLNLGTTDLPKCDDTKKSSITL-----QQQSVVFSGNLDNETVA 935

  Fly  1076 IYESLRPISTPAIF---------------SNKPVL-----------KSHS--------------- 1099
            |:.....|..|..|               |:||.|           ||::
Human   936 IHSLNSSIKDPLQFVFSDEETSSDVKSSCSSKPNLDTMCKGFQSPDKSNNSTGTAITLNSKLICL 1000

  Fly  1100 ---------------LAE---LKRPQNLPN-----------HSINHHCKTHAINANGNVLENG-- 1133
                           ::|   :|:..::.|           .|..|...:...:|:.::::.|
Human  1001 GTPCVISGSISSNTDVSEDRTMKKNSDVLNLTQMYSEIPTVESETHLGTSDPFSASTDIVKQGLV 1065

  Fly  1134 -------------------------------------LDHEQDEIKENSNGQVRTNKQGHGSNT- 1160
                                                 |..|||:..|......:..:.|:...|
Human  1066 ENYFGSQSSTDISDTCAVSYSNALSPQKETSEKEISNLQQEQDKEDEEEEQDQQMVQNGYYEETD 1130

  Fly  1161 -----------------------------NSKHKRKG------------QLASAVQEAP------ 1178
                                         ||.:.|.|            ...||.:|:|
Human  1131 YSALDGTINAHYTSRDELMEERLTKSEKINSDYLRDGINMPTVCTSGCLSFPSAPRESPCNVKYS 1195

  Fly  1179 --------------------PSISLLE---------FEKYREEFRKQIKYQGSIYSDYVQLASEL 1214
                                .|||..|         |.:.:||. |.:|..|.:||:...|||.:
Human  1196 SKSKFDAITKQPSSTSYNFTSSISWYESSPKPQIQAFLQAKEEL-KLLKLPGFMYSEVPLLASSV 1259

  Fly  1215 PYFYISDEYRAFSPNGMHLVICVHGLDGNSADLRLVRTYLELGLPGVNLEFLMSERNQGDTFSDF 1279
            |||.:.:|  ..|.:|:||::|||||||||||||||:||:||||||..::||||||||.|||:||
Human  1260 PYFSVEEE--DGSEDGVHLIVCVHGLDGNSADLRLVKTYIELGLPGGRIDFLMSERNQNDTFADF 1322

  Fly  1280 DTMTDRLVTEILYHIDSCALNPARISFVAHSLGTIIVRSALARPQMRPLLPRLHTFLSLSGPHLG 1344
            |:|||||:.||:.:|...:|..::|||:.||||.:|:||.|.||:.:..|.:|||||||||||||
Human  1323 DSMTDRLLDEIIQYIQIYSLTVSKISFIGHSLGNLIIRSVLTRPRFKYYLNKLHTFLSLSGPHLG 1387

  Fly  1345 TLYNTSGLVNMGMWFMQKWKKSGSLLQLCMRDTTDMRNSFLYRLSQRSTLHHFKNILLCGSSQDR 1409
            ||||:|.|||.|:|||||||||||||||..||.:|.|.:|||:||.::.||:|||::|.||.|||
Human  1388 TLYNSSALVNTGLWFMQKWKKSGSLLQLTCRDHSDPRQTFLYKLSNKAGLHYFKNVVLVGSLQDR 1452

  Fly  1410 YVPAHSARLELCKAAMRDSSSLGTIYREMVHNIIAPILARPELTLARFDVHHALPHTANTLIGRA 1474
            |||.||||:|:||.|::|..| |.||.||:||::.|:|...:..|.|::|.:|||:||::|||||
Human  1453 YVPYHSARIEMCKTALKDKQS-GQIYSEMIHNLLRPVLQSKDCNLVRYNVINALPNTADSLIGRA 1516

  Fly  1475 AHIAVLDSELFIEKFMLIAGLKYF 1498
            |||||||||:|:|||.|:|.||||
Human  1517 AHIAVLDSEIFLEKFFLVAALKYF 1540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32333	NP_001261246.1	DUF3657	150..227	CDD:463558	31/76 (41%)
		DUF676	1227..1422	CDD:309968	129/194 (66%)
FAM135A	NP_001317925.1	DUF3657	111..172	CDD:463558	31/76 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	595..618		6/42 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1088..1119		5/30 (17%)
		DUF676	1270..1465	CDD:309968	129/194 (66%)