Protein Alignment CG32333 and fam135a

DIOPT Version :10

• Sequence 1: NP_001261246.1
• Gene: CG32333 / 38142
• FlyBaseID: FBgn0052333
• Length: 1499
• Species: Drosophila melanogaster
• Sequence 2: XP_017214263.1
• Gene: fam135a / 566435
• ZFINID: ZDB-GENE-080130-1
• Length: 1344
• Species: Danio rerio
• Alignment Length: 1642
• Identity: 513/1642 - (31%)
• Similarity: 721/1642 - (43%)
• Gaps: 443/1642 - (26%)

  Fly     1 MGDLQATIEFVVELHKFFNVDLFQRGLYQVRCGLRVSPRLLVQVETSIPEASGPGKQNGHANGAN 65
            |.::|||:||.||||||:||||||||.||||..::|.||:..:||.|:
Zfish     1 MTEVQATVEFSVELHKFYNVDLFQRGFYQVRASMKVPPRIPQRVEASL----------------- 48

  Fly    66 ATDHGSSDSERGELSPGEVPRLHESPPGGS--CSSASVINGSGASRIFQILYRNEEVPLRDIIHF 128
                                 ||   |.||  ...|||.:....|:.|||||:|||:.:.|:..|
Zfish    49 ---------------------LH---PIGSDLAFPASVQDDVVCSKTFQILYKNEEIVVNDVFVF 89

  Fly   129 RSHLLVDSR------HLKESIERAEFSLQLELWFGEQNGSSSLNGNGGGSGMGSFSGPASSALTL 187
            :..:|:|::      .::||:...:|.|.|:|:|.:                |.:|....|:|..
Zfish    90 KVMMLLDAKKGVFLLQVEESLNEVDFQLCLDLFFTD----------------GDYSPEEPSSLQS 138

  Fly   188 ASTRNLQLNFHPGRGLHYHLPVLFDYFHLAAISVGIHASLVALHQPYIK-----KSVFSYMKFCA 247
            .|:|.|:|:|...||:|:|:.|:||||||:.||..|||||||||||.|.     ||  :::...|
Zfish   139 ISSRTLRLHFSLHRGIHHHVNVMFDYFHLSVISATIHASLVALHQPLISFPRPVKS--TWLNRNA 201

  Fly   248 PRSSKPWSAGKLSCRGNTSPGPLEAVFFGPQIGGTTKCSGGPAGR--------LLQSRAIHREIC 304
            |..||           ::...|||.|.|    |.|......|.|:        |..:.::|:.:|
Zfish   202 PAQSK-----------DSLIPPLETVVF----GSTYVKQLSPDGKSFLVSDQCLQHAFSLHQNMC 251

  Fly   305 SLLLGAIEQLKATLNEFSTVLPPSINSQIGSPPLR---------------------ENDTGERLQ 348
            :.||.|.:.|...|...:..||.|...::..|.::                     |.|...||.
Zfish   252 ANLLRAYQSLFCYLTSLTKNLPASQRMELAKPSMQVLYERVLRRPYPPGQRHVYIEELDVEVRLH 316

  Fly   349 LLLDQAKQ-LEAEEDFAIRANSDIAQLCAESIFWWRRVLLASRSSTAVHTLLARKHHILRVRRFA 412
            .|.:|.|| .|:.::.|...|.::||||:..:..|...|.....:..|..|||::||.|||:|||
Zfish   317 ELCEQVKQKAESPDELAELVNMNLAQLCSLLMALWGNFLEVVSLNERVFVLLAQEHHTLRVQRFA 381

  Fly   413 EGFFVLEQPRHAAAAGCPDQTNGSPSPGHCQGYVAIAELARRSRYLQSLPPLPVHCTPIDGDASS 477
            |.||.||.||.:|.|         ....|...:..:....:.|.|..|||||||.|..:|||.:|
Zfish   382 EAFFCLEHPRQSALA---------YQELHAHSHQQMTTAIKSSSYFLSLPPLPVECADLDGDVNS 437

  Fly   478 LPLIFEDRYVTTNSTYARRRSGSDPQLEDAVSVVGVQKKKVDKTHSSSSLNGIKDCLACHFDYDY 542
            ||:||||||:   .:....|.|  |.|       |:|..:.....:.:..:..|||:|
Zfish   438 LPIIFEDRYL---ESVTEDRDG--PWL-------GLQNNRSGSVSAKADRSNSKDCIA------- 483

  Fly   543 PQTNGSGPAHPHAKCVITPRFALGGEVLQASLTIA------PSKEAAPEAVAPPTLRHNLSRHSV 601
                 ||...|:.            :..|||...|      ||.::..:::   .|:.|....:.
Zfish   484 -----SGALGPYP------------DKQQASFATAWPEQNEPSLKSKAKSI---KLKKNTKTENS 528

  Fly   602 TGLLEDLDLDS-------SLPARHSKSL-------------DQL-DGCEGLATNPVSTTNNHTLP 645
            ..|:.....||       :|...||:..             |:| ||.:.|..|  .||..|...
Zfish   529 KKLIRQSSKDSVVLTGYKNLKVPHSEKTIKSKDIDHQCNQRDELEDGGKFLLQN--ETTTTHCAQ 591

  Fly   646 RLQADDLMRNICEFRQRYGKFDYLHEIKLLNPPKQQQQAVPQQQQQCNNGYNSLPKSMVPPRNSY 710
              .|.|     |......|....|.: ...|....|.||.|    |...|..:....:.|   ::
Zfish   592 --NAKD-----CTSGNLQGNATILSD-GFPNLMSLQMQARP----QAGTGAEAAAARVDP---TH 641

  Fly   711 PP--------------PPPSQHTTM------PRSSSSQIPRAVEIARVRVSDIK----------- 744
            ||              |......|:      .|::...:|   ||.:...|:.|
Zfish   642 PPAGLRHIDVKPSDKDPYQGDKVTVLLPHHPERTTKRDVP---EITQTDFSEFKSRVGDGATFVG 703

  Fly   745 --------EMLRQGQLRKESSSSESDMMQKLQMLSSNSVPFRLEGTSNNNTTSSDPNTSGFSESL 801
                    :.:.|...|...|..||:.....|:...:..||...|            ....:|.:
Zfish   704 PCGAALRNDNIPQASSRLSDSGIESEPSSATQLAPVSPSPFAPIG------------IEAPTELI 756

  Fly   802 PNLAPP--PEFDSDSQLRRQRSNSTSSLSEESGWVSSRRSSLAISSPDTITSTGMTNRQRHTQLN 864
            |:..||  |.....:.|......|||.:   ||..||..|..::.|.|.: .|..|:|:...
Zfish   757 PHRPPPLSPASRGATALEGLNPESTSGV---SGVQSSLTSINSLPSDDEV-ETEATSRKSSI--- 814

  Fly   865 LGMGMAMETRL--NGEQLRLRL--QKVLEQQQLQQQHPHKNRKRQAGTSSQSRTPARQQTEVHKK 925
                :..|..|  :||...|.|  .:||.||           |...|....|...:|.:|...
Zfish   815 ----LVQEQSLIFSGESQSLLLTNSRVLAQQ-----------KASHGDGMDSALQSRCETSAS-- 862

  Fly   926 ISSVTVNIKRERSRYQLDRL-----RHLPNGESTEVEEMEPPPRRNRHKTACEKSKSDFDITSLK 985
                             |||     ..||.|          |...:..:||.:.|.|   :||..
Zfish   863 -----------------DRLVGSNETDLPGG----------PEACSEPQTAAQSSTS---VTSST 897

  Fly   986 DM---------------------QPLDAVCLPPPQQFQDQEQELALVLAPPPPDEFRDPPPEPAP 1029
            ||                     .||:...:           .|.:...|...||..:
Zfish   898 DMVKKGFVENYFGSRSSTDISEISPLETAAI-----------TLGIQTCPNANDEEDE------- 944

  Fly  1030 AAPIAPVPPPAAALPPTGKTKIVACHLPPPLKERQPIGAIDNPVYHIYESLRPISTPAIFSNKPV 1094
                                           :|.|....|:|..|...:.:       ::.|
Zfish   945 -------------------------------EEEQEHEMIENGYYEETDGV-------VYVN--- 968

  Fly  1095 LKSHSLAELKRPQNLPNHSINHHCKTHAINANGNVL---ENGLDHEQDEIKENSNGQVRTNKQGH 1156
                         .||..  ...|:..  .|.|..|   ..||:..|:....::.  :||...|.
Zfish   969 -------------GLPED--EGRCEDG--GAEGRTLFYDHLGLEQLQETYIPSAG--IRTRPTGP 1014

  Fly  1157 GSNTNSKHKRKGQLASAVQEAPPSISLLEFEKYREEFRKQIKYQGSIYSDYVQLASELPYFYISD 1221
            ...::.         ....::.|:..:..|.:.:||. ||:|..|.:||:...|||.:|||.:.:
Zfish  1015 APTSSD---------LCWYKSAPTAQMTAFVQAKEEL-KQLKLPGFLYSEVADLASTVPYFSMDE 1069

  Fly  1222 EYRAFSPNGMHLVICVHGLDGNSADLRLVRTYLELGLPGVNLEFLMSERNQGDTFSDFDTMTDRL 1286
            :...  .:|:||::|||||||||||||||:|||||||||..::||||||||.|||:||::|||||
Zfish  1070 DENC--DDGIHLIVCVHGLDGNSADLRLVKTYLELGLPGARIDFLMSERNQNDTFADFESMTDRL 1132

  Fly  1287 VTEILYHIDSCALNPARISFVAHSLGTIIVRSALARPQMRPLLPRLHTFLSLSGPHLGTLYNTSG 1351
            :.||:.:|....|..::||||.||||.:||||.|.||:.:..|.||||||||||||||||||:|.
Zfish  1133 LDEIVQYIQIYNLTVSKISFVGHSLGNLIVRSVLTRPRFKCYLSRLHTFLSLSGPHLGTLYNSSA 1197

  Fly  1352 LVNMGMWFMQKWKKSGSLLQLCMRDTTDMRNSFLYRLSQRSTLHHFKNILLCGSSQDRYVPAHSA 1416
            |||.|:|||||||||||||||..||.:|.|.:|||:||:::.|..|||::|.||.||||||.|||
Zfish  1198 LVNTGLWFMQKWKKSGSLLQLTCRDHSDPRQTFLYKLSKKAGLQFFKNVVLVGSLQDRYVPYHSA 1262

  Fly  1417 RLELCKAAMRDSSSLGTIYREMVHNIIAPILARPELTLARFDVHHALPHTANTLIGRAAHIAVLD 1481
            |:|:||.|::|..: |.:|.||:.|::.|:|...:..|.|:||.||||:|||:||||||||||||
Zfish  1263 RIEMCKTALKDKQT-GPVYAEMIENLLLPVLQNKDCNLVRYDVIHALPNTANSLIGRAAHIAVLD 1326

  Fly  1482 SELFIEKFMLIAGLKYF 1498
            ||:|:|||.|:||||:|
Zfish  1327 SEIFLEKFFLVAGLKFF 1343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32333	NP_001261246.1	DUF3657	150..227	CDD:463558	29/76 (38%)
		DUF676	1227..1422	CDD:309968	130/194 (67%)
fam135a	XP_017214263.1	DUF3657	117..178	CDD:463558	29/76 (38%)
		DUF676	1075..1268	CDD:309968	130/192 (68%)