Protein Alignment CG32333 and FAM135B

DIOPT Version :9

• Sequence 1: NP_001261246.1
• Gene: CG32333 / 38142
• FlyBaseID: FBgn0052333
• Length: 1499
• Species: Drosophila melanogaster
• Sequence 2: XP_011515358.1
• Gene: FAM135B / 51059
• HGNCID: 28029
• Length: 1410
• Species: Homo sapiens
• Alignment Length: 1703
• Identity: 514/1703 - (30%)
• Similarity: 707/1703 - (41%)
• Gaps: 499/1703 - (29%)

  Fly     1 MGDLQATIEFVVELHKFFNVDLFQRGLYQVRCGLRVSPRLLVQVETSIPEASGPGKQNGHANGAN 65
            |.::|.|:||.||||||:||||||||.||:|..|:||.|:..::..||               |.
Human     1 MSEIQGTVEFSVELHKFYNVDLFQRGYYQIRVTLKVSSRIPHRLSASI---------------AG 50

  Fly    66 ATDHGSSDSERGELSPGEVPRLHESPPGGSCSSASVINGSGASRIFQILYRNEEVPLRDIIHFRS 130
            .|:..|               ||         ||.|.:.:..||:|||||||||||:.|.:.||.
Human    51 QTESSS---------------LH---------SACVHDSTVHSRVFQILYRNEEVPINDAVVFRV 91

  Fly   131 HLLVDSRHLKESIERAEFSLQLELWFGEQNGSSSLNGNGGGSGMGSFSGPASSALTLASTRNLQL 195
            |||:....:::::...:|.|:::|.|  .:....|....|.              .:.|:|.|.|
Human    92 HLLLGGERMEDALSEVDFQLKVDLHF--TDSEQQLRDVAGA--------------PMVSSRTLGL 140

  Fly   196 NFHPGRGLHYHLPVLFDYFHLAAISVGIHASLVALHQPYIKKSVFSYMKFCAPRSSKPWSAGKLS 260
            :|||..|||:.:||:||||||:.|||.:||:||||.||.|        .|..|        |:.|
Human   141 HFHPRNGLHHQVPVMFDYFHLSVISVTVHAALVALQQPLI--------SFTRP--------GRGS 189

  Fly   261 CRGNTSPG--------PLEAVFFGPQIGGTTKCSGG----PAGRLLQSRAIHREICSLLLGAIEQ 313
            ..|...|.        .||.:.||......|...|.    ....:..:...||::|.|||.|...
Human   190 WLGKGGPDTGQEQSIISLENLVFGAGYCKPTSSEGSFYITSENCMQHAHKWHRDLCLLLLHAYRG 254

  Fly   314 LKATLNEFSTVLPPSINSQIGSPPLRENDTGERLQLLLDQAKQLEAEEDFAIRANSDIAQLCAES 378
            |:.........:|...::::.:..:.|.     |..|..:.:.|...|..|.:.:.|:|.|.:..
Human   255 LRLHFLVIMRDIPELPHTELEALAVEET-----LSQLCSELQMLNNPEKIAEQISKDLAWLTSHM 314

  Fly   379 IFWWRRVLLASRSSTAVHTLLARKHHILRVRRFAEGFFVLEQPRHAAAAGCPDQTNGSPSPGHCQ 443
            :..|.:.|......:.|.|.|.::||.||||||:|.||.:|   |...|....|.|...:  |.|
Human   315 MTLWTQFLDTVTLHSQVTTYLTQEHHTLRVRRFSEAFFYME---HQKLAVLTFQENLIQT--HSQ 374

  Fly   444 GYVAIAELARRSRYLQSLPPLPVHCTPIDGDASSLPLIFEDRYVTTNSTYARRRSGSDPQLEDAV 508
            ..:.|    |.|.||.|:||||..|..||||.::||:|||||||
Human   375 LSLDI----RNSEYLTSMPPLPAECLDIDGDWNTLPVIFEDRYV--------------------- 414

  Fly   509 SVVGVQKKKVDKTHSSSSLNGIKDCLACHFDYDYPQTNGSGPAHPHAKCVITPRFALGGEVLQAS 573
                                   ||                ||..| ...:.|.|    :|...|
Human   415 -----------------------DC----------------PATGH-NLSVYPNF----DVPVTS 435

  Fly   574 LTIAPSKEAAPEAVAPPTLRHNLSRHSVTGLLEDLDLDSSLPARHSKSLDQLDGCEGLATNPVS- 637
            .||...|:.....:    :..|||      ..|||.|.:..|:       |:|..|.:...|..
Human   436 PTIMNLKDKEDNCM----VNSNLS------FREDLVLSTIKPS-------QMDSDEEVIRCPEPG 483

  Fly   638 ---TTNNHTLPRLQADDLMRNICEFRQRY---GKFDYLHEIKLLNPPKQQQQAVPQQQQQCNNGY 696
               .|.||           .::|...|.|   |:|             |.:..||  :.:|..|.
Human   484 ENVATQNH-----------MDMCSESQVYISIGEF-------------QNKAGVP--EDECWTGQ 522

  Fly   697 NSLPKSMVPPRNSYPPPPPSQHTTMPRSSSSQIPRAVEIARVRVSDIKEMLRQGQLRKESSSSES 761
            .|       ...:||..........|.....|.|....|      |:|
Human   523 TS-------DAGTYPVADVDTSRRSPGPEDGQAPVLTYI------DVK----------------- 557

  Fly   762 DMMQKLQMLSSNSVPFRLEGTSNNNTTSSDPNTSGFSESLPNLAPPPEFDSDSQLRRQRSNSTSS 826
                     |||..|.|.|                         |...|::..:.|..|......
Human   558 ---------SSNKNPSRAE-------------------------PLVAFNAQHESRSSRDKYGLD 588

  Fly   827 LSEESGWVSSRRSSLAISSPDTITSTGMTNRQRHTQLNLGMGMAMETRLNGEQLRL--------- 882
            .:..|..|.......||||..|..         |....||.|:..|.::....|:|
Human   589 RTGLSKVVVGGSHQNAISSDKTTL---------HELSTLGKGIDQEGKMVLLSLKLTPSEPCDPL 644

  Fly   883 --RLQKVLE-QQQLQQQHPHKNR---------KRQAGTSSQSRTPARQQTEVHKKISSVTVNIKR 935
              .|::.|: :..|:..|..:..         ||.:...|.|        .:..:.|||..:..|
Human   645 SSTLREPLDIRSSLKDSHTEEQEELSVLSGVIKRSSSIISDS--------GIESEPSSVAWSEAR 701

  Fly   936 ERSRYQLDRLRHLPNGESTEVEEMEPPPRRNR-HKTACEKSKSDFDITSLKD--MQPLDAVCLPP 997
            .|:       ..||    ::.|.:.|..||:. |:.:.|...::.: |||..  ...|.::...|
Human   702 SRA-------LELP----SDREVLHPFVRRHALHRNSLEGGHTESN-TSLPSGIQASLTSISSLP 754

  Fly   998 PQQFQDQEQELAL------VLAP---PPPDEFRDPPPEPAPAAPIAP---------VPPPAAALP 1044
               |::.|:|:||      |.||   .|.:...|...:........|         .|...:.|.
Human   755 ---FEEDEREVALTKLTKSVSAPHISSPEEAAEDADTKQQDGGFAEPSDMHSKSQGSPGSCSQLC 816

  Fly  1045 PTGKTKIVACHLPPPLKE-------RQPIGAIDNP---------VYHIYESLRPISTPAIFSNKP 1093
            ....|...|.|   ||.|       :|..|.||.|         ..|.....|..:||.:.:...
Human   817 GDSGTDAGADH---PLVEIVLDADNQQGPGYIDIPKGKGKQFDAQGHCLPDGRTENTPGVETKGL 878

  Fly  1094 VLKSHSLAELKRPQNLPNH-SINHHCK--THAINANGNVLEN-------GLDHEQ---------- 1138
            .||...:..|:.|:....| ::....|  ...:|.....|.|       ||...|
Human   879 NLKIPRVIALENPRTRSLHRALEETPKGMPKDLNVGQQALSNSGISEVEGLSQHQVPELSCTSAA 943

  Fly  1139 DEIKENSNGQVRTN-----------KQGHGSNTNSKHKR----------------KGQ------- 1169
            |.|..||.||...:           .:|..:...:|||.                |.|
Human   944 DAINRNSTGQQSQSGSPCIMDDTAFNRGVNAFPEAKHKAGTVCPTVTHSVHSQVLKNQELKAGTS 1008

  Fly  1170 -----------------------------------LASAVQEAPP-------------------- 1179
                                               .:|..:|.|.
Human  1009 IMGSHLTSAETFTLDSLKAVEVVNLSVSCTATCLPFSSVPKETPARAGFSSKQTLFPITHQPLGS 1073

  Fly  1180 -------SISLLE------------FEKYREEFRKQIKYQGSIYSDYVQLASELPYFYISDEYRA 1225
                   |.:|.|            |.:.:|:|:|::|.:|.:|||...|||::|||...:|...
Human  1074 FGVVSTHSSTLDEEVSERMFSVFSSFYQAKEKFKKELKIEGFLYSDLTVLASDIPYFPPEEEEEN 1138

  Fly  1226 FSPNGMHLVICVHGLDGNSADLRLVRTYLELGLPGVNLEFLMSERNQGDTFSDFDTMTDRLVTEI 1290
            .. :|:|||:|||||||||||||||:|::||||||..|:|||||:||.|||:|||||||||:.||
Human  1139 LE-DGIHLVVCVHGLDGNSADLRLVKTFIELGLPGGKLDFLMSEKNQMDTFADFDTMTDRLLDEI 1202

  Fly  1291 LYHIDSCALNPARISFVAHSLGTIIVRSALARPQMRPLLPRLHTFLSLSGPHLGTLYNTSGLVNM 1355
            :.||....|:.:||||:.||||.||:||.|.||:.|..|.:|||||||||||||||||.|.||:.
Human  1203 IQHIQLYNLSISRISFIGHSLGNIIIRSVLTRPRFRYYLNKLHTFLSLSGPHLGTLYNNSTLVST 1267

  Fly  1356 GMWFMQKWKKSGSLLQLCMRDTTDMRNSFLYRLSQRSTLHHFKNILLCGSSQDRYVPAHSARLEL 1420
            |:|.|||.|||||||||..||..|:|..|||:|||::.|.:|||::|..|.||||||.||||:|:
Human  1268 GLWLMQKLKKSGSLLQLTFRDNADLRKCFLYQLSQKTGLQYFKNVVLVASPQDRYVPFHSARIEM 1332

  Fly  1421 CKAAMRDSSSLGTIYREMVHNIIAPILARPELTLARFDVHHALPHTANTLIGRAAHIAVLDSELF 1485
            ||.|::|..: |.:|.||::|::.|::...:.||.|.:|.||||:||||||||||||||||||||
Human  1333 CKTALKDRHT-GPVYAEMINNLLGPLVEAKDCTLIRHNVFHALPNTANTLIGRAAHIAVLDSELF 1396

  Fly  1486 IEKFMLIAGLKYF 1498
            :|||.|:|||.||
Human  1397 LEKFFLVAGLNYF 1409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32333	NP_001261246.1	DUF3657	150..226	CDD:289180	27/75 (36%)
		MhpC	1223..>1447	CDD:223669	139/223 (62%)
		DUF676	1227..1422	CDD:282860	129/194 (66%)
FAM135B	XP_011515358.1	DUF3657	111..170	CDD:289180	26/74 (35%)
		DUF676	1140..1334	CDD:282860	129/194 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140722
Domainoid	1	1.000	280	1.000	Domainoid score	I1691
eggNOG	1	0.900	-	-		E1_KOG2205
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	638	1.000	Inparanoid score	I823
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132320at2759
OrthoFinder	1	1.000	-	-		FOG0001840
OrthoInspector	1	1.000	-	-		otm41161
orthoMCL	1	0.900	-	-		OOG6_102700
Panther	1	1.100	-	-	LDO	PTHR12482
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3354
SonicParanoid	1	1.000	-	-		X1527
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.880