DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32333 and C09D4.4

DIOPT Version :9

Sequence 1:	NP_001261246.1	Gene:	CG32333 / 38142	FlyBaseID:	FBgn0052333	Length:	1499	Species:	Drosophila melanogaster
Sequence 2:	NP_491605.2	Gene:	C09D4.4 / 172200	WormBaseID:	WBGene00015635	Length:	916	Species:	Caenorhabditis elegans

Alignment Length:	1538	Identity:	277/1538 - (18%)
Similarity:	455/1538 - (29%)	Gaps:	686/1538 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VELHKFFNVDLFQRGLYQVRCGLRVSPRLLVQVETSIPEASGPGKQNGHANGANATDHGSSDSER 76
            ::|.:||||||..||.||:    |:.||...::              |..:.::.|:   .|.:.
Worm    13 IQLCEFFNVDLSDRGYYQI----RLRPRKTAEI--------------GSVDISHDTE---GDRDT 56

  Fly    77 GELSPGEVPRLHESPPGGSCSSASVINGSGASRIFQILYRNEEVPLRDIIH----FRSHLLVDSR 137
            |..:...:...|            |..|:..|:..::.|::|:..|.|..|    |.|.|
Worm    57 GPKTSSNILLAH------------VYQGAAVSKTVEVTYQHEKFNLDDWFHISVQFNSTL----- 104

  Fly   138 HLKESIERAEFSLQLELWFGEQNGSSSLNGNGGGSGMGSFSGPASSALTLASTRNLQLNFHPGRG 202
               ...|..:..:::||.:                 |..:..|...:....:.|.:::...|.|.
Worm   105 ---NLCEPQKLEIEIELLY-----------------MDRYHPPQYESFVKITKRIVEIPLDPTRL 149

  Fly   203 LHYHLPVLFDYFHLAAISVGIHASLVALHQPYIKKSVFSYMKFCAPRSSKPWSAGKLSCRGNTSP 267
            :.....:.||..:|:||::                ||||.:...|.|..|..::..|....:|..
Worm   150 VAAARSLYFDSTYLSAITM----------------SVFSSLVMVATRQRKANASESLLQASSTKS 198

  Fly   268 GPLEAVFFGPQIGGTTKCSGGPAGRLL------------QSRAIHREICSLLLGAIEQLKATLNE 320
            ..|..|:            ...|..||            .||.|:..:..::|....::||.|.:
Worm   199 TKLRRVY------------NSSAHALLFATRSIQQFIVNNSRLINASVSVVVLDVQTEMKAALQQ 251

  Fly   321 FSTVLPPSINSQIGSPPLRENDTGERLQLLLDQAKQLEAEEDFAIRANSDIAQLCAESIFWWRRV 385
            |.:          ...|.|..:|                          |:.:...:....::::
Worm   252 FDS----------SDHPTRCVET--------------------------DVCEWSTKITLIYQQM 280

  Fly   386 LLASRSSTAVHTLLARKHHILRVRRFAEGFFVLEQPRHAAAAGCPDQTNGSPSPGHCQGYVAIAE 450
            |:..|.|..::..|.......|...|.|.|::.|:|........|...        .:.|.:|.:
Worm   281 LILFRKSKELNQQLLLIFDKQRRAVFREAFWINERPIDKCLIRTPVSV--------LEHYKSIIK 337

  Fly   451 LARRSRYLQSLPPLPVHCTPIDGDASSLPLIFEDRYVTTNSTYARRRSGSDPQLEDAVSVVGVQK 515
            :    .||:.||...:.|...|......|:||||.:
Worm   338 V----DYLRKLPRCTIFCEETDCPGEFCPIIFEDVF----------------------------- 369

  Fly   516 KKVDKTHSSSSLNGIKDCLACHFDYDYPQTNGSGPAHPHAKCVITPRFALGGEVLQASLTIAPSK 580

Worm   370 ----------------------------------------------------------------- 369

  Fly   581 EAAPEAVAPPTLRHNLSRHSVTGLLEDLDLDSSLPARHSKSLDQLDGCEGLATNPVSTTNNHTLP 645
                            :|:|| |||:
Worm   370 ----------------TRNSV-GLLD--------------------------------------- 378

  Fly   646 RLQADDLMRNICEFRQRYGKFDYLHEIKLLNPPKQQQQAVPQQQQQCNNGYNSLPKSMVPPRNSY 710
                                                          .||.
Worm   379 ----------------------------------------------LNNA--------------- 382

  Fly   711 PPPPPSQHTTMPRSSSSQIPRAVEIARVRVSDIKEMLRQGQLRKESSSSESDMMQKLQMLSSNSV 775
                 ::..|:|.|:|..:.:|.|    :....:|.||
Worm   383 -----NRQVTIPNSASMPVVKAHE----KHKSFREKLR--------------------------- 411

  Fly   776 PFRLEGTSNNNTTSSDPNTSGFSESLPNLAPPPEFDSDSQLRRQRSNSTSSLSEESGWVSSRRSS 840
                                                          |.|..|      :..||.|
Worm   412 ----------------------------------------------NETRKL------IHPRRKS 424

  Fly   841 LAISSPDTITSTGMTNRQRHTQLNLGMGMAMETRLNGEQLRLRLQKVLEQQQLQQQHPHKNRKRQ 905
            |..|                                              |.|       :||..
Worm   425 LDCS----------------------------------------------QSL-------SRKLD 436

  Fly   906 AGTSSQSRTPARQQTEVHKKISSVTVNIKRERSRYQLDRLRHLPNGESTEVEEMEPPPRRNRHKT 970
            .|.:|:|||...::|........:.              |:::||.:........|.|.|:   |
Worm   437 GGVTSRSRTKTLKETTSTDGGGGLL--------------LKNIPNSQENNFSPEFPGPSRD---T 484

  Fly   971 ACEKSKSDFDITSLKDMQPLDAVCLPPPQQFQDQEQELALVLAPPPPDEFRDPPPEPAPAAPIAP 1035
            |.|...                 |...|            :.:|.|..||
Worm   485 ATESPS-----------------CSSEP------------IASPSPSSEF--------------- 505

  Fly  1036 VPPPAAALPPTGKTKIVACHLPPPLKERQPIGAIDNPVYHIYESLRPISTPAIFSNKPVLKSHSL 1100
                       |:.....                        |..:....|.|  :|..:.|..:
Worm   506 -----------GRCSAAG------------------------ELFQDDGIPLI--SKESVTSEEI 533

  Fly  1101 AELKRPQNLPNHSINHHCKTHAINANGNVLENGLDHEQDEIKENSNGQVRTNKQGHGSNTNSKHK 1165
            |...|.               :::|: :||...:.                      |:|:.|
Worm   534 ANALRT---------------SVSAD-DVLSCRVT----------------------SSTDMK-- 558

  Fly  1166 RKGQLASAVQEAPPSISLLEFEKYREE------FRKQIKYQGSIYSDYVQLASELPY-------F 1217
                    :.|..|...:.|||..||.      .|:|..|:|.:||:....::..|.       .
Worm   559 --------LTEEHPKDRMAEFELLREREAAKKMLRQQTNYEGHLYSEQSGRSTAGPVCTPIKSSL 615

  Fly  1218 YISDEYRAFSPNGMHLVICVHGLDGNSADLRLVRTYLE---------LGLPGVN-------LEFL 1266
            .|.|.. ..|.|..|||:.||||:|:..||...|..|:         :.:.|.:       .|:|
Worm   616 VIGDPV-VRSKNKTHLVVFVHGLEGSQEDLVPFRCGLDQAIAAHYHCIQMEGRDFDEEPWAFEYL 679

  Fly  1267 MSERNQGDTFSDFDTMTDRLVTEILYHIDSCALNPARISFVAHSLGTIIVRSALA---RPQMRPL 1328
            ||..|:..|::|..||...|::|:..:::....:..||||:|||||.:|||||:.   ..:|:.:
Worm   680 MSSANRSQTWADITTMAHNLLSEVREYVEEARNDIQRISFLAHSLGGVIVRSAVGLAPEVEMQWM 744

  Fly  1329 LPRLHTFLSLSGPHLGTLYNTSGLVNMGMWFMQKWKKSGSLLQLCMRDTTDMRNSFLYRLSQRST 1393
            :.|.:|.::::.||||..| ....::.|:.|::.||||.|:.||..||:.|..:||:|:.|..:.
Worm   745 IDRCYTLMTINSPHLGLAY-VQKHIHWGVQFVKWWKKSRSMEQLSFRDSVDFASSFVYKTSLNNA 808

  Fly  1394 LHHFKNILLCGSSQDRYVPAHSARLELCKAAMRDSSSLGTIYREMVHNIIAPIL-ARPELTLARF 1457
            ...||||||.|:..|:.||..|:.|...|.:..|.|..|..||||:...::.|. :.....|.|:
Worm   809 CGKFKNILLVGTPHDQLVPYMSSLLVPSKISSEDQSQFGEAYREMMTACLSSIQNSEKSENLVRY 873

  Fly  1458 DVHHALPHTANT--LIGRAAHIAVLDSELFIEKFMLIAGLKYF 1498
            ...|.| .::||  :.|||||:..|:..:||||...|:.::||
Worm   874 TTFHQL-GSSNTQKITGRAAHVIALEDSVFIEKLFNISAVRYF 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32333	NP_001261246.1	DUF3657	150..226	CDD:289180	12/75 (16%)
		MhpC	1223..>1447	CDD:223669	84/242 (35%)
		DUF676	1227..1422	CDD:282860	76/213 (36%)
C09D4.4	NP_491605.2	DUF676	624..832	CDD:309968	75/208 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158690
Domainoid	1	1.000	124	1.000	Domainoid score	I3424
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	215	1.000	Inparanoid score	I2336
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132320at2759
OrthoFinder	1	1.000	-	-		FOG0001840
OrthoInspector	1	1.000	-	-		oto19566
orthoMCL	1	0.900	-	-		OOG6_102700
Panther	1	1.100	-	-	LDO	PTHR12482
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3354
SonicParanoid	1	1.000	-	-		X1527
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.930