Protein Alignment CG32333 and fam135b

DIOPT Version :10

• Sequence 1: NP_001261246.1
• Gene: CG32333 / 38142
• FlyBaseID: FBgn0052333
• Length: 1499
• Species: Drosophila melanogaster
• Sequence 2: XP_001343106.4
• Gene: fam135b / 100003594
• ZFINID: ZDB-GENE-140106-172
• Length: 1475
• Species: Danio rerio
• Alignment Length: 1684
• Identity: 529/1684 - (31%)
• Similarity: 759/1684 - (45%)
• Gaps: 397/1684 - (23%)

  Fly     1 MGDLQATIEFVVELHKFFNVDLFQRGLYQVRCGLRVSPRLLVQVETSIPEASGPGKQNGHANGAN 65
            |.::|.|:||.:|||||.||||||||.||||.|||||||
Zfish     2 MSEVQGTVEFSLELHKFHNVDLFQRGFYQVRAGLRVSPR-------------------------- 40

  Fly    66 ATDHGSSDSERGELSPGEVP-RLHESPPG--GSC--SSASVINGSGASRIFQILYRNEEVPLRDI 125
                              || |:..:.||  |.|  |:|.|.:|...|||||||||||||.|.|.
Zfish    41 ------------------VPHRITATTPGYTGECSFSNAGVHDGGVFSRIFQILYRNEEVTLEDH 87

  Fly   126 IHFRSHLLVDSRHLKESIERAEFSLQLELWF--GEQNGSSSLNGNGGGSGMGSFSGPASSALTLA 188
            |:||.|||:|...::|::...:..|:|:|.|  .||..:.                  .|::.:.
Zfish    88 INFRLHLLLDGERVEEAVSEVDVQLKLDLHFTDNEQQLAD------------------ISSVPVI 134

  Fly   189 STRNLQLNFHPGRGLHYHLPVLFDYFHLAAISVGIHASLVALHQPYI---KKSVFSYMKFCAPRS 250
            |:|.|.|:|||.:|||:||||:||||||:.|||.|||||||||||.|   :....:::...:|.|
Zfish   135 SSRTLGLHFHPQQGLHHHLPVMFDYFHLSVISVSIHASLVALHQPLISFARSGKGTWLGKGSPES 199

  Fly   251 SKPWSA----GKLSCRGNTSPGPLEAVFFGPQIGGTTKCSGGPAGRLLQSRAIHREICSLLLGAI 311
            ..|.||    ..:...|...|.|.|..|:.|    :..|       |.::...||.||.|||.|.
Zfish   200 EAPPSAMSVENLMFGAGYCKPVPTEGSFYVP----SENC-------LQRAYTWHRRICKLLLAAH 253

  Fly   312 EQLKATLNEFSTVLPPSINSQIGSPPLRENDTGERLQLLLDQAKQLEAEEDFAIRANSDIAQLCA 376
            ..|::........:|...:.|....||.|......::|.|....:..||:     .:.|:.||||
Zfish   254 RALRSYYTTLMKEIPQLQHIQTEDLPLEETLNQLTIELQLQSGHEKVAEQ-----ISKDLTQLCA 313

  Fly   377 ESIFWWRRVLLASRSSTAVHTLLARKHHILRVRRFAEGFFVLEQPRHAAAAGCPDQTNGSPSPGH 441
            :....|.:.|.::..:..:.:.||::||.||||||:|.:|..|.|:.::.....:..|     .|
Zfish   314 QLSALWTQFLESTVPNPYIRSYLAQEHHTLRVRRFSEAYFFTEHPKESSLTFQEELIN-----RH 373

  Fly   442 CQGYVAIAELARRSRYLQSLPPLPVHCTPIDGDASSLPLIFEDRYVTT-----NSTYARRRS--G 499
            .|    ::...|.|.||..:|||||.|..||||.||||:|||||||.|     |..:.:.::  .
Zfish   374 AQ----VSTEMRNSDYLLRMPPLPVECLDIDGDWSSLPIIFEDRYVDTPCLDYNVVHEQNQAVLN 434

  Fly   500 SDPQLEDAVSVVGVQKKKVDKTHSSSSLNGIKDCLACHFDYDYPQTNGSGPAHPHAKCVITPRFA 564
            |.|..| ...|.|......:||..:|                .|.|:...|  |...|...|.:
Zfish   435 SQPCFE-PTRVKGQTASPAEKTQDTS----------------LPATSPEEP--PSEDCTEMPTY- 479

  Fly   565 LGGEVLQASLTIAPSK-EAAPEAVAPPTLRHNLSRHSVTGLLEDLDLDSSLPARHSKSLDQLDGC 628
                     :|:...: :...|.:.|......|:.|     :|:.|               :|||
Zfish   480 ---------MTLTDHQDDDVTEHIKPRPQAETLTDH-----VEEAD---------------IDGC 515

  Fly   629 EGLATNPVSTTNNHTLPR-------------LQADDLMRN----ICE-----------------F 659
            |.:.|:  |.:..|::..             :..||::.|    .|:                 |
Zfish   516 EFITTS--SNSRIHSVDEVTCQYENDGNTMSVDTDDVIDNQEKTSCQKEAANESDHTSSQQTNVF 578

  Fly   660 RQ------------------RYGKFDYL----HEIKLL------NPPKQQQQAV-----PQQQQQ 691
            ..                  ..|.|::|    |:..|.      :|..|:.|.|     .|...:
Zfish   579 NSGQPLLLVPTDLGELPDLTSLGSFEFLPTYNHDDNLETPGDTGSPDNQEPQTVFDNRHIQAPAK 643

  Fly   692 CNNGYNSLP----KSMVPPRNSYPPPPPSQHTTMPRSSSSQIPRAVEIARVRVSD-IKEMLRQGQ 751
            ...|.::.|    |:.:|..:.....|........|..|...||.|.:...::.: ...::....
Zfish   644 DYGGKDTSPGILLKATLPGTDPLVTSPSRNVIHQIRRLSETPPRGVFLGGAKLMNRSSSVISDSG 708

  Fly   752 LRKESSS------------SESDMMQKLQMLSSNSVPFRLEGTSNNNTTSSDPNTSGFSESLPNL 804
            :..|.||            ...|::|.|....: :....|||....:..|....|.....|:.:|
Zfish   709 IESEPSSVAWTLEGRGVVAGGRDILQSLARCRT-AHQSSLEGLQTESHGSLPSATQASLTSISSL 772

  Fly   805 APPPEFDSDSQLRRQRSNSTSSLSEESGWVSSRRSSLAISSPDTITSTGMT-NRQRHT--QLNLG 866
              |.|.:.|.||        ::|::.:       |:..|||||.......| |::..|  :.|..
Zfish   773 --PYEEEEDRQL--------NTLTKSA-------SAPQISSPDDTEEDRETPNQETRTVCEANQV 820

  Fly   867 MGMAMET---RLNGEQLRLRLQKVLEQQQLQQQHPHK----NRKRQAGTSSQSRTPARQQTEVHK 924
            .|...|.   |.|.|... .:::.|:.::..||....    |..|....:...:|    ..||.:
Zfish   821 TGTRCEANPMRQNKESAN-EVKRNLQMEETTQQDTTNVLVANHIRDEAANEVKQT----LQEVTR 880

  Fly   925 KISSVTVNIKRERSRYQLDRLRHLPNGESTEVEEMEPPPRRNRHKTACEKSKSDFDITSLKDMQP 989
            :..:.|.| :.:|:....::||......:...:.::...|.:.::|    |..:.||....:...
Zfish   881 EDGNTTTN-QEKRNVCVANQLRKSEVAANEVKQNLQGVFREDGNET----SNQEIDIEESSNQDI 940

  Fly   990 LDAVCLPPP----QQF-QDQEQELALVLAPPPPDEFRDPPPEPAPAAPIAPVPPPAAALPPTG-- 1047
            .|...:.|.    ||| .|..::..|........:|:                         |
Zfish   941 TDLTFVNPEMLLYQQFLMDSGKDATLEELTENSKDFQ-------------------------GNI 980

  Fly  1048 ---------KTKIVACHLPPPLKERQPIGAIDNPVYHIYESLRPISTPAIFSNKPVLKSHSLAEL 1103
                     .|:|..|.......:|:    :::..||  :....||...|..|:        .|:
Zfish   981 LLKEYLMDESTEICRCEDEYCEHKRK----LESNQYH--KDADDISVCHIHLNE--------LEV 1031

  Fly  1104 KRPQNLPNHSINHHCKTHAINAN-----GNVLENGLDHEQDEIKENSNGQVRTNK-QGHG-SNTN 1161
            ...:|||..:.|.. :||.|.||     .:.:|...:....:|.|   ||.|.|| ...| :..|
Zfish  1032 ASMENLPEPTTNDK-RTHGIAANEKERPADPIEPPTNERDQQILE---GQSRINKVPSTGLAFVN 1092

  Fly  1162 SKHKRKGQLA----------SAVQEAPPSIS---------------------------------- 1182
            .|......|:          |:|....||:|
Zfish  1093 KKVVEVVNLSVSCAPTCLPFSSVLRDSPSVSGISTRQATSPITHQPLGSFGIISSNSFFGADQEI 1157

  Fly  1183 ---LLEFEKYREEFRKQIKYQGSIYSDYVQLASELPYFYISDEYRAFSPNGMHLVICVHGLDGNS 1244
               ::.|.|.:|...:::.::|::|||...||||.|||...::...|. :|:|||:|||||||||
Zfish  1158 NERMINFFKAKEALLRELVFRGTLYSDLPYLASEHPYFPPEEDDTEFE-DGIHLVVCVHGLDGNS 1221

  Fly  1245 ADLRLVRTYLELGLPGVNLEFLMSERNQGDTFSDFDTMTDRLVTEILYHIDSCALNPARISFVAH 1309
            ||||||:|::||||||..|:||||||||.|||:|||||||||:.||:.||....|...||||:.|
Zfish  1222 ADLRLVKTFVELGLPGSRLDFLMSERNQTDTFADFDTMTDRLLDEIIQHIQLYNLTIHRISFIGH 1286

  Fly  1310 SLGTIIVRSALARPQMRPLLPRLHTFLSLSGPHLGTLYNTSGLVNMGMWFMQKWKKSGSLLQLCM 1374
            |||.:|:||.|.||:.|..|.:|||||||||||||||||.|.||:.|:|.|||.|||||||||..
Zfish  1287 SLGNVIIRSVLTRPRFRCYLCKLHTFLSLSGPHLGTLYNNSTLVSTGLWLMQKLKKSGSLLQLTF 1351

  Fly  1375 RDTTDMRNSFLYRLSQRSTLHHFKNILLCGSSQDRYVPAHSARLELCKAAMRDSSSLGTIYREMV 1439
            ||.||.|.:|||.||::..|..|||::|..|.||||||.||||:|:|:.|::|.:: |.:|.||:
Zfish  1352 RDHTDPRQTFLYTLSKKPGLQFFKNVVLVASPQDRYVPFHSARIEMCRTALKDRTT-GPVYTEMI 1415

  Fly  1440 HNIIAPILARPELTLARFDVHHALPHTANTLIGRAAHIAVLDSELFIEKFMLIAGLKYF 1498
            :|::.|:|:.|...|.|.:|.||||:||||||||||||||||||||:|||:|:|||.||
Zfish  1416 NNLLQPLLSAPNCRLIRQNVFHALPNTANTLIGRAAHIAVLDSELFLEKFLLVAGLNYF 1474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32333	NP_001261246.1	DUF3657	150..227	CDD:463558	33/78 (42%)
		DUF676	1227..1422	CDD:309968	129/194 (66%)
fam135b	XP_001343106.4	DUF3657	112..173	CDD:463558	33/78 (42%)
		DUF676	1205..1399	CDD:309968	129/194 (66%)