DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tfc and acanb

DIOPT Version :9

Sequence 1:	NP_612091.1	Gene:	tfc / 38141	FlyBaseID:	FBgn0035199	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	XP_021326217.1	Gene:	acanb / 559593	ZFINID:	ZDB-GENE-100422-16	Length:	1376	Species:	Danio rerio

Alignment Length:	411	Identity:	90/411 - (21%)
Similarity:	152/411 - (36%)	Gaps:	106/411 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SLASVDSGHNSPVTTIPVAEPISQVPHGFQLGQNNHI---SSSSNISRSGGGNGRDKRGAQLDPS 73
            |.:...||..|.:.:.|.:...|....||  |.::.|   |||:::.:|....|..  |....||
Zfish   936 SASGFGSGIASGIESSPASAFGSSSASGF--GSSSAIGLESSSASVFKSVSVTGTS--GYPNHPS 996

  Fly    74 EIARQNQITQQIFANYLERRLFPNRTANQKIPTIADILPKPKPSPRPRPRGFAASDGGNFKRSGG 138
                 .::::.|.....|..:|.:....:.  |:             ||........|:.:.||.
Zfish   997 -----GEVSENIQRQDGEMIIFTDDEVTEL--TL-------------RPTAGTEQGRGSVEISGE 1041

  Fly   139 GAQRNRLAAAASKRQSGYNRKRLREEQEEEEEADD--QERDQQPLANQEDFDYDVQE-------- 193
            |:           ....|....:........|::|  .|||::.....|.||...:.
Zfish  1042 GS-----------TPEPYTEDSISVSNSTSHESNDLLPERDEKISVTMEAFDVTDKSPLITTPTN 1095

  Fly   194 ----------SLQSVESEQHDQYYGNIFHRDPSENEVDND-C-PN---------------CVDES 231
                      |||..:|..           :||.||..:| | ||               |...|
Zfish  1096 IPVLTTPSSASLQMPKSTM-----------NPSVNEAPSDPCDPNPCGQGLCSLQDGVALCQCHS 1149

  Fly   232 QYTPNKWTMPLLKLGE------KRYYLGIFFKANWFKATQYCRYHGMHLASISSQEENDRLEKHI 290
            .::....::.:....|      ...|:....:..|..|.|:|:....||.|||||:|.:.::...
Zfish  1150 GFSGENCSVLVQGCAEGWMEFMGSCYIHFDERETWTSAEQHCQELNSHLVSISSQQEQEFVKTQA 1214

  Fly   291 RDFGLGHEHFWISGTDLADEGNFFWMATGRPITFTNWNAGEPNNFRYENGEEENC-LELWNRDGK 354
            :|:.      ||...|...:..|.| ..|.|:.:.||...:|:|: :..||:  | :.:|:.:|
Zfish  1215 QDYQ------WIGLNDKDVQNEFRW-TDGSPLEYENWRPNQPDNY-FSTGED--CVVMIWHENG- 1268

  Fly   355 GLKWNDSPCSFETYFVCEVQP 375
              :|||.||::...|.|:.:|
Zfish  1269 --QWNDVPCNYHLPFTCKSEP 1287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tfc	NP_612091.1	CLECT	249..373	CDD:153057	37/124 (30%)
acanb	XP_021326217.1	Ig	45..159	CDD:325142
		Link_domain_CSPGs_modules_1_3	158..252	CDD:239594
		Link_domain_CSPGs_modules_2_4	260..354	CDD:239597
		Xlink	459..553	CDD:306661
		Link_domain_CSPGs_modules_2_4	560..655	CDD:239597
		CLECT	1163..1284	CDD:321932	37/133 (28%)
		CCP	1290..1347	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8750
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4956
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940