DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tfc and CLEC4A

DIOPT Version :9

Sequence 1:	NP_612091.1	Gene:	tfc / 38141	FlyBaseID:	FBgn0035199	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_057268.1	Gene:	CLEC4A / 50856	HGNCID:	13257	Length:	237	Species:	Homo sapiens

Alignment Length:	163	Identity:	37/163 - (22%)
Similarity:	64/163 - (39%)	Gaps:	45/163 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 VDESQYT--PNKWTMPLLKLGEKRYYLGIFF----KANWFKATQYCRYHGMHLASISSQEENDRL 286
            |:|:.::  |..|         |.:....:|    .|:|..:.:.|.....||..|::|||.|.:
Human    98 VEETAWSCCPKNW---------KSFSSNCYFISTESASWQDSEKDCARMEAHLLVINTQEEQDFI 153

  Fly   287 EKHIRD-----FGL----GHEHF-WISGTDLADEGNFFWMATGRPITFTNWNAGEPNNFRYENGE 341
            .:::::     .||    |..|: |:..|...:...|             |:..||::      .
Human   154 FQNLQEESAYFVGLSDPEGQRHWQWVDQTPYNESSTF-------------WHPREPSD------P 199

  Fly   342 EENCLEL-WNRDGKGLKWNDSPCSFETYFVCEV 373
            .|.|:.| :.:..|...|||..|......|||:
Human   200 NERCVVLNFRKSPKRWGWNDVNCLGPQRSVCEM 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tfc	NP_612091.1	CLECT	249..373	CDD:153057	31/138 (22%)
CLEC4A	NP_057268.1	ITIM motif. /evidence=ECO:0000269\|PubMed:20530286	5..10
		CLECT_DC-SIGN_like	106..232	CDD:153060	34/153 (22%)
		Mannose binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	195..197		1/1 (100%)
		N-acetyl-D-glucosamine binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	207..209		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150874
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BFQ9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840