DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tfc and Clec4a

DIOPT Version :9

Sequence 1:	NP_612091.1	Gene:	tfc / 38141	FlyBaseID:	FBgn0035199	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001005899.2	Gene:	Clec4a / 474143	RGDID:	1359662	Length:	240	Species:	Rattus norvegicus

Alignment Length:	170	Identity:	45/170 - (26%)
Similarity:	72/170 - (42%)	Gaps:	45/170 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 NCV------DESQYT--PNKWTMPLLKLGEKRYYL----GIFFKANWFKATQYCRYHGMHLASIS 278
            ||:      :|..::  |..|.    ..|...|::    ..:.||:|.::.:.|...|.||..|.
  Rat    91 NCIKNVLLMEEKSWSCCPKNWK----PFGSHCYWVTKHTSTYSKASWNESEKNCFSMGAHLLVIH 151

  Fly   279 SQEENDRLEKHI-RD----FGL---GHEHF-WISGTDLADEGNFFWMATGRPITFTNWNAGEPNN 334
            |:||.|.:...: ||    .||   ||..: |:|.|.......|             |:.|||::
  Rat   152 SKEEQDFITGILNRDAAYFIGLWDSGHRQWQWVSQTPYNASATF-------------WHKGEPSS 203

  Fly   335 FRYENGEEENCLELWNRDGKGLKWNDSPCSFETYFVCEVQ 374
                  ::|.|: :.|....|..|||.|||.:...||:::
  Rat   204 ------DDEKCV-IINHLNSGWGWNDIPCSGKQQSVCQMK 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tfc	NP_612091.1	CLECT	249..373	CDD:153057	39/136 (29%)
Clec4a	NP_001005899.2	ITIM motif	5..10
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..38
		CLECT_DC-SIGN_like	107..235	CDD:153060	42/151 (28%)
		Mannose binding. /evidence=ECO:0000250\|UniProtKB:Q9UMR7	200..202		1/1 (100%)
		N-acetyl-D-glucosamine binding. /evidence=ECO:0000250\|UniProtKB:Q9UMR7	211..213		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344291
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BFQ9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840