DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tfc and CLEC12B

DIOPT Version :9

Sequence 1:	NP_612091.1	Gene:	tfc / 38141	FlyBaseID:	FBgn0035199	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001123470.1	Gene:	CLEC12B / 387837	HGNCID:	31966	Length:	276	Species:	Homo sapiens

Alignment Length:	218	Identity:	43/218 - (19%)
Similarity:	73/218 - (33%)	Gaps:	49/218 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 QEEEEEADDQERDQQPLANQEDFDYDVQESLQSVESEQHDQ----YYGNIFHRDPSENEVDNDCP 225
            |::::....|..:...|:.:|:|   ::..:.||...|...    ....|.|..      |:.|.
Human    86 QQQQDNLSQQLGNSNNLSMEEEF---LKSQISSVLKRQEQMAIKLCQELIIHTS------DHRCN 141

  Fly   226 NCVDESQYTPNKWTMPLLKLGEKRYYLGIFFKANWFKATQYCRYHGMHLASISSQEENDRLEKHI 290
            .|....|:..|..           ||.....:..|..:.:.|......|..|.|.||.|.|....
Human   142 PCPKMWQWYQNSC-----------YYFTTNEEKTWANSRKDCIDKNSTLVKIDSLEEKDFLMSQP 195

  Fly   291 RDFGLGHEHFWISGTDLADEGNFFWMATGRPITFTNWNAGEPNNFRYENGEEENCLELWNRDGKG 355
            .   |....||:         ...|.::||...:.:.:...|:.|..:..::.|       ..||
Human   196 L---LMFSFFWL---------GLSWDSSGRSWFWEDGSVPSPSLFSTKELDQIN-------GSKG 241

  Fly   356 LKWND------SPCSFETYFVCE 372
            ..:..      |.||.|.:::||
Human   242 CAYFQKGNIYISRCSAEIFWICE 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tfc	NP_612091.1	CLECT	249..373	CDD:153057	28/130 (22%)
CLEC12B	NP_001123470.1	ITIM motif	5..10
CLEC12B	NP_001123470.1	CLECT_NK_receptors_like	143..265	CDD:153063	31/152 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000