DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tfc and CD209

DIOPT Version :9

Sequence 1:	NP_612091.1	Gene:	tfc / 38141	FlyBaseID:	FBgn0035199	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_066978.1	Gene:	CD209 / 30835	HGNCID:	1641	Length:	404	Species:	Homo sapiens

Alignment Length:	244	Identity:	64/244 - (26%)
Similarity:	97/244 - (39%)	Gaps:	55/244 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 RLAAAA------SKRQSGYNR-KRLREEQEEEEEADDQERDQQPLANQEDFDYDVQESLQSVESE 201
            ||.||.      ||:|..|.. .||:....|..|...|:...|.|...:....::.|     :|:
Human   175 RLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPE-----KSK 234

  Fly   202 QHDQYYGNIFHRDPSENEVDNDCPNCVDESQYTPNKWTMPLLKLGEKRYYLG-IFF----KANWF 261
            |.:.|.    .....:..|:..|..|       |.:||          ::.| .:|    :.||.
Human   235 QQEIYQ----ELTQLKAAVERLCHPC-------PWEWT----------FFQGNCYFMSNSQRNWH 278

  Fly   262 KATQYCRYHGMHLASISSQEENDRLEKHIRDFGLGHEHFWISGTDLADEGNFFWMATGRPI--TF 324
            .:...|:..|..|..|.|.||.:.|:   ......:...|:..:||..||.:.|: .|.|:  :|
Human   279 DSITACKEVGAQLVVIKSAEEQNFLQ---LQSSRSNRFTWMGLSDLNQEGTWQWV-DGSPLLPSF 339

  Fly   325 TN-WNAGEPNNFRYENGEEENCLELWNRDGKGLKWNDSPCSFETYFVCE 372
            .. ||.|||||.     .||:|.|.   .|.|  |||..|:...:::|:
Human   340 KQYWNRGEPNNV-----GEEDCAEF---SGNG--WNDDKCNLAKFWICK 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tfc	NP_612091.1	CLECT	249..373	CDD:153057	39/132 (30%)
CD209	NP_066978.1	Endocytosis signal	14..15
		Endocytosis signal. /evidence=ECO:0000255	16..18
		Endocytosis signal. /evidence=ECO:0000255	31..34
		transmembrane domain	36..59
		PilO	38..>184	CDD:294757	4/8 (50%)
		neck domain	60..249		19/82 (23%)
		CLECT_DC-SIGN_like	256..379	CDD:153060	43/154 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BFQ9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840