DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tfc and ACAN

DIOPT Version :9

Sequence 1:NP_612091.1 Gene:tfc / 38141 FlyBaseID:FBgn0035199 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_001356197.1 Gene:ACAN / 176 HGNCID:319 Length:2568 Species:Homo sapiens


Alignment Length:187 Identity:46/187 - (24%)
Similarity:76/187 - (40%) Gaps:54/187 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   187 FDYDVQESLQSVESEQHDQYYGNIFHRDPSENEVDNDCPNCVDESQYTPNKWTMPLLKLGEKRYY 251
            ::.|:.|..|.|..|..::|.|:.:...|.                                   
Human  2346 YEGDLCEIDQEVCEEGWNKYQGHCYRHFPD----------------------------------- 2375

  Fly   252 LGIFFKANWFKATQYCRYHGMHLASISSQEENDRLEKHIRDFGLGHEHFWISGTDLADEGNFFWM 316
                 :..|..|.:.||....||:||.:.||.:.:..:.:|:.      ||...|...||:|.| 
Human  2376 -----RETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQ------WIGLNDRTIEGDFRW- 2428

  Fly   317 ATGRPITFTNWNAGEPNNFRYENGEEENC-LELWNRDGKGLKWNDSPCSFETYFVCE 372
            :.|.|:.|.||...:|:|| :..||:  | :.:|:..|   :|||.||::...|.|:
Human  2429 SDGHPMQFENWRPNQPDNF-FAAGED--CVVMIWHEKG---EWNDVPCNYHLPFTCK 2479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tfcNP_612091.1 CLECT 249..373 CDD:153057 38/125 (30%)
ACANNP_001356197.1 Ig_Aggrecan 43..154 CDD:143308
G1-A 48..141
G1-B 152..247
Link_domain_CSPGs_modules_1_3 153..247 CDD:239594
G1-B' 253..349
Link_domain_CSPGs_modules_2_4 254..349 CDD:239597
G2-B 477..571
Link_domain_CSPGs_modules_1_3 478..572 CDD:239594
G2-B' 578..673
Link_domain_CSPGs_modules_2_4 579..674 CDD:239597
KS 677..849
PHA03307 716..>975 CDD:223039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 734..979
12 X 6 AA approximate tandem repeats of E-[GVE]-P-[SFY]-[APT]-[TSP] 773..844
CS-1 852..1612
35 X 19 AA approximate tandem repeats of E-[IVDG]-[LV]-[EV]-[GTI]-[STA]-[ATV]-[SP]-[GA]-[VIFAD]- [GEDL]-[DE]-[LVI]-[SG]-[GERK]-[LV]-P-S-G 942..1612
PRK15387 <1433..>1614 CDD:185285
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1499..1526
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1543..1649
CS-2 1613..2277
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1687..1772
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1784..1827
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1883..1902
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1948..1977
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2048..2204
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2249..2281
EGF_CA 2283..2313 CDD:238011
EGF_CA 2316..2352 CDD:238011 1/5 (20%)
CLECT_CSPGs 2358..2481 CDD:153058 42/175 (24%)
CCP 2485..2541 CDD:153056
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2548..2568
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 77 1.000 Domainoid score I8850
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4956
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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