DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tfc and Vcan

DIOPT Version :9

Sequence 1:	NP_612091.1	Gene:	tfc / 38141	FlyBaseID:	FBgn0035199	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001074718.1	Gene:	Vcan / 13003	MGIID:	102889	Length:	3354	Species:	Mus musculus

Alignment Length:	485	Identity:	99/485 - (20%)
Similarity:	168/485 - (34%)	Gaps:	167/485 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VDSG--------HNS--PVTTI-----PVAEPISQVPHGFQ-----LGQNNHISSSSNISRSGGG 60
            ||:|        |.|  ||:|:     .:..|..:|....:     ||.|.|.:...::||.
Mouse  2803 VDNGVSKFPEVPHTSAQPVSTVTSSQKSIESPFKEVHANIEETIKPLGGNVHRTEPPSMSRD--- 2864

  Fly    61 NGRDKRGAQLDPSEIARQNQITQQIFANYLERRL---FPNRTANQKIP--TIADILPKPKPSPRP 120
                   ..||.||...::::.:::..:..:...   |||: |...||  |:..:.........|
Mouse  2865 -------PALDVSEDESKHKLLEELETSPTKPETSQDFPNK-AKDHIPGETVGMLAGIRTTESEP 2921

  Fly   121 RPRGFAASDGGNFKRSGGGAQRNRLAAAASKRQSGYNRKRLREEQE------------------- 166
               ...|.|    ...||..|:...|:||.:.::|...:.:::|.|
Mouse  2922 ---VITADD----MELGGATQQPHSASAAFRVETGMVPQPIQQEPERPTFPSLEINHETHTSLFG 2979

  Fly   167 EEEEADDQERDQQPL---ANQ----EDFDYDVQESLQ-----------------SVESEQHDQYY 207
            |...|..:::..|.:   :||    ...|.....:|.                 |.||.:....|
Mouse  2980 ESILATSEKQVSQKILDNSNQATVSSTLDLHTAHALSPFSILDNSNETAFLIGISEESVEGTAVY 3044

  Fly   208 ---------------GNIFHRDPS------------ENEVD------NDCPN---CVD------- 229
                           |..:..:.|            :.|:|      |.|.|   |||
Mouse  3045 LPGPDLCKTNPCLNGGTCYPTETSYVCTCAPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRC 3109

  Fly   230 ----------------ESQYTPNKWTMPLLKLGEKRYYLGIFFKANWFKATQYCRYHGMHLASIS 278
                            ...|..:|:        :.:.|.....:..|..|.:.||..|.||.||.
Mouse  3110 LCLPSYVGALCEQDTETCDYGWHKF--------QGQCYKYFAHRRTWDAAERECRLQGAHLTSIL 3166

  Fly   279 SQEENDRLEKHIRDFGLGHEHFWISGTDLADEGNFFWMATGRPITFTNWNAGEPNNFRYENGEEE 343
            |.||...:.:      :||::.||...|...|.:|.| ..|..:.:.||...:|::| :..||:
Mouse  3167 SHEEQMFVNR------VGHDYQWIGLNDKMFEHDFRW-TDGSALQYENWRPNQPDSF-FSAGED- 3222

  Fly   344 NCLE-LWNRDGKGLKWNDSPCSFETYFVCE 372
             |:. :|:.:|   :|||.||::...:.|:
Mouse  3223 -CVVIIWHENG---QWNDVPCNYHLTYTCK 3248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tfc	NP_612091.1	CLECT	249..373	CDD:153057	37/125 (30%)
Vcan	NP_001074718.1	IG_like	29..147	CDD:214653
		Ig_Versican	36..151	CDD:143309
		Link_domain_CSPGs_modules_1_3	150..244	CDD:239594
		Link_domain_CSPGs_modules_2_4	251..346	CDD:239597
		GAG-alpha (glucosaminoglycan attachment domain)	348..1308
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	625..646
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..863
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	881..908
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1010..1088
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1252..1288
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1396..1421
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1458..1524
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1924..1963
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2471..2490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2849..2904		14/65 (22%)
		EGF_CA	3049..3083	CDD:238011	2/33 (6%)
		EGF_CA	3085..3121	CDD:238011	7/35 (20%)
		CLECT_CSPGs	3127..3250	CDD:153058	39/143 (27%)
		CCP	3254..3310	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9266
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4956
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940