DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tfc and Bcan

DIOPT Version :9

Sequence 1:	NP_612091.1	Gene:	tfc / 38141	FlyBaseID:	FBgn0035199	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	XP_030108256.1	Gene:	Bcan / 12032	MGIID:	1096385	Length:	900	Species:	Mus musculus

Alignment Length:	463	Identity:	103/463 - (22%)
Similarity:	165/463 - (35%)	Gaps:	136/463 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DSGH-------NSPVT-----TIPVAEPIS--QVPHGFQLGQNNHISSSSNISRSGGGNG---RD 64
            ||.|       :||.:     .:.|.|.:.  |:|......::.....|..||..|||..   .|
Mouse   371 DSAHPSASSEASSPASDGLEAIVTVTEKLEELQLPQEAMESESRGAIYSIPISEDGGGGSSTPED 435

  Fly    65 KRGAQLDPSE-----IARQNQITQQIFANYLERRLFPN-----------------RTANQKIPT- 106
            ...|...|.|     ||...:.:::......|...|.:                 |..:..:||
Mouse   436 PAEAPRTPLESETQSIAPPTESSEEEGVALEEEERFKDLEALEEEKEQEDLWVWPRELSSPLPTG 500

  Fly   107 ------IADILP----------KPKPSPRPRPRGFAASD-----GGNFKRSGGGAQRNRLAAAAS 150
                  ::.:.|          .|.|.| ||.||..|..     .|:...:.||| |.......|
Mouse   501 SETEHSLSQVSPPAQAVLQLGASPSPGP-PRVRGPPAETLLPPREGSPTSTPGGA-REVGGETGS 563

  Fly   151 KRQSGYNRKRLREEQEEEEEADDQERDQQPL--------ANQEDFDYDVQE----------SLQS 197
            ...||..|        |.|||.....:..|.        ....:.:...:|          |:|:
Mouse   564 PELSGVPR--------ESEEAGSSSLEDGPSLLPATWAPVGPRELETPSEEKSGRTVLAGTSVQA 620

  Fly   198 -----VESEQHDQYYGNIFHRDPSENEVDNDCPN---CVDESQYTPNKWTMPLLKLGEKRYYLGI 254
                 .:|..|    |.:.....|.:.:.:.|.|   |::|.:   ....:.|...|.....:|:
Mouse   621 QPVLPTDSASH----GGVAVAPSSGDCIPSPCHNGGTCLEEKE---GFRCLCLPGYGGDLCDVGL 678

  Fly   255 FF------------------KANWFKATQYCRYHGMHLASISSQEENDRLEKHIRDFGLGHEHFW 301
            .|                  :.:|.:|...||..|.||.||.:.||.|.:....|      |:.|
Mouse   679 HFCSPGWEAFQGACYKHFSTRRSWEEAESQCRALGAHLTSICTPEEQDFVNDRYR------EYQW 737

  Fly   302 ISGTDLADEGNFFWMATGRPITFTNWNAGEPNNFRYENGEEENCLEL-WNRDGKGLKWNDSPCSF 365
            |...|...||:|.| :.|.|:.:.|||.|:|::: :.:|  |||:.: |:..|   :|:|.||::
Mouse   738 IGLNDRTIEGDFLW-SDGAPLLYENWNPGQPDSY-FLSG--ENCVVMVWHDQG---QWSDVPCNY 795

  Fly   366 ETYFVCEV 373
            ...:.|::
Mouse   796 HLSYTCKM 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tfc	NP_612091.1	CLECT	249..373	CDD:153057	41/142 (29%)
Bcan	XP_030108256.1	Ig	65..174	CDD:386229
		Link_domain_CSPGs_modules_1_3	173..267	CDD:239594
		Link_domain_CSPGs_modules_2_4	274..369	CDD:239597
		Treacle	499..>635	CDD:367557	30/149 (20%)
		EGF	643..672	CDD:333761	6/31 (19%)
		CLECT	681..804	CDD:382969	39/136 (29%)
		CCP	808..865	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9266
eggNOG	1	0.900	-	-		E33208_3BFQ9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S11806
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4956
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.790