Protein Alignment tfc and Acan

DIOPT Version :9

• Sequence 1: NP_612091.1
• Gene: tfc / 38141
• FlyBaseID: FBgn0035199
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_001348429.1
• Gene: Acan / 11595
• MGIID: 99602
• Length: 2170
• Species: Mus musculus
• Alignment Length: 383
• Identity: 82/383 - (21%)
• Similarity: 130/383 - (33%)
• Gaps: 112/383 - (29%)

  Fly    25 TTIPVAEPISQV---PHGFQLGQ---------NNHISSSSNISRSGGGNGRDKRGAQLDPSEI-- 75
            |.:.:..|.::|   |..||.|.         :...|::|:|.....|.......|..|.:||
Mouse  1776 TDLEMTTPSTEVNSNPWTFQEGTREGSAAPEVSGESSTTSDIDTGTSGVPSATPMASGDRTEISG 1840

  Fly    76 -----------ARQNQITQQIFANYLERRLFPNRTANQKIPTIADILPKPKPSPRPRPRG----- 124
                       |..:.||:..:|.       |.|...:.:..|        .||.|...|
Mouse  1841 EWSDHTSEVNVAISSTITESEWAQ-------PTRYPTETLQEI--------ESPNPSYSGEETQT 1890

  Fly   125 ----FAASDGGNFKRSGGGAQRNRLAAAASKRQSGYNRKRLREEQEEEEEADDQERDQQPLANQE 185
                .:.:|......|.|               ||         :.|...||..|....|..|
Mouse  1891 AETTMSLTDAPTLSSSEG---------------SG---------ETESTVADIDECLSSPCLN-- 1929

  Fly   186 DFDYDVQESLQSVESEQHDQYYGNIFHRDPSENEVDNDCPNCVDESQYTPNKWTMPLLKLGEKRY 250
              .....::|.:........|.||:                |..:.:.....||.     .:...
Mouse  1930 --GATCVDALDTFTCLCLPSYRGNL----------------CEIDQEQCEEGWTK-----FQGHC 1971

  Fly   251 YLGIFFKANWFKATQYCRYHGMHLASISSQEENDRLEKHIRDFGLGHEHFWISGTDLADEGNFFW 315
            |.....:..|..|.:.||....||:||.:.||.:.:.|:.:|:.      ||...|...||:|.|
Mouse  1972 YRHFHDRETWVDAERRCREQQSHLSSIVTPEEQEFVNKNAQDYQ------WIGLNDRTIEGDFRW 2030

  Fly   316 MATGRPITFTNWNAGEPNNFRYENGEEENC-LELWNRDGKGLKWNDSPCSFETYFVCE 372
             :.|..:.|..|...:|:|| :..||:  | :.:|:..|   :|||.||:::..|.|:
Mouse  2031 -SDGHSLQFEKWRPNQPDNF-FATGED--CVVMIWHERG---EWNDVPCNYQLPFTCK 2081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tfc	NP_612091.1	CLECT	249..373	CDD:153057	38/125 (30%)
Acan	NP_001348429.1	Ig_Aggrecan	43..154	CDD:143308
		G1-A	48..140
		G1-B	152..247
		Link_domain_CSPGs_modules_1_3	153..247	CDD:239594
		G1-B'	253..349
		Link_domain_CSPGs_modules_2_4	254..349	CDD:239597
		G2-B	486..580
		Link_domain_CSPGs_modules_1_3	487..581	CDD:239594
		G2-B'	587..682
		Link_domain_CSPGs_modules_2_4	588..683	CDD:239597
		KS	685..803
		Herpes_ICP4_C	689..>1027	CDD:332854
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	737..1079
		CS-1	805..1231
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1108..1239
		AidA	<1171..>1630	CDD:330218
		Cell attachment site. /evidence=ECO:0000255	1171..1173
		CS-2	1232..1917		32/179 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1299..1465
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1491..1538
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1586..1671
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1782..1838		12/55 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1861..1914		13/91 (14%)
		EGF_CA	1918..1954	CDD:238011	8/55 (15%)
		CLECT_CSPGs	1960..2083	CDD:153058	40/140 (29%)
		CCP	2087..2143	CDD:153056

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9266
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4956
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940