DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tfc and CLEC4M

DIOPT Version :9

Sequence 1:	NP_612091.1	Gene:	tfc / 38141	FlyBaseID:	FBgn0035199	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_055072.3	Gene:	CLEC4M / 10332	HGNCID:	13523	Length:	399	Species:	Homo sapiens

Alignment Length:	239	Identity:	58/239 - (24%)
Similarity:	99/239 - (41%)	Gaps:	45/239 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 RLAAAASKRQSGYNRKRLREEQEEEEEADDQERDQQPLANQEDFDYDVQESLQSVESEQHDQYYG 208
            ||.||..:.......:.:.:|..|.:.|..:..::..|  ||  .|.....|::...|..||...
Human   187 RLKAAVGELPEKSKLQEIYQELTELKAAVGELPEKSKL--QE--IYQELTQLKAAVGELPDQSKQ 247

  Fly   209 NIFHRDPSE--NEVDNDCPNCVDESQYTPNKWTMPLLKLGEKRYYLG-IFF----KANWFKATQY 266
            ...:::.::  ...:..|.:|       |..||          ::.| .:|    :.||..:...
Human   248 QQIYQELTDLKTAFERLCRHC-------PKDWT----------FFQGNCYFMSNSQRNWHDSVTA 295

  Fly   267 CRYHGMHLASISSQEENDRLEKHIRDFGLGHEHFWISGTDLADEGNFFWMATGRPI--TFTN-WN 328
            |:.....|..|.:.||.:.|:...   ...:...|:..:||..||.:.|: .|.|:  :|.. ||
Human   296 CQEVRAQLVVIKTAEEQNFLQLQT---SRSNRFSWMGLSDLNQEGTWQWV-DGSPLSPSFQRYWN 356

  Fly   329 AGEPNNFRYENGEEENCLELWNRDGKGLKWNDSPCSFETYFVCE 372
            :|||||    :|.|: |.|.   .|.|  |||:.|..:.|::|:
Human   357 SGEPNN----SGNED-CAEF---SGSG--WNDNRCDVDNYWICK 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tfc	NP_612091.1	CLECT	249..373	CDD:153057	38/132 (29%)
CLEC4M	NP_055072.3	Endocytosis signal. /evidence=ECO:0000250	14..15
		transmembrane domain	44..71
		7 X approximate tandem repeats	108..269		17/92 (18%)
		DUF342	<140..251	CDD:302792	15/67 (22%)
		CLECT_DC-SIGN_like	268..391	CDD:153060	42/154 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150816
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BFQ9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1509611at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850