Protein Alignment Sac1 and FIG4

DIOPT Version :9

• Sequence 1: NP_001189016.1
• Gene: Sac1 / 38137
• FlyBaseID: FBgn0283500
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: NP_055660.1
• Gene: FIG4 / 9896
• HGNCID: 16873
• Length: 907
• Species: Homo sapiens
• Alignment Length: 648
• Identity: 178/648 - (27%)
• Similarity: 283/648 - (43%)
• Gaps: 160/648 - (24%)

  Fly     9 VYDDMNLYIAPQSFIIEPNGGDELLVIGRHDKVTRV---QPASGGLVANLRPTRRIC--GVLGTI 68
            :.||.::|  .|..:.|        ::||.|...|.   |..|.||.      |.:.  ||:|.:
Human    51 IIDDRHVY--TQQEVRE--------LLGRLDLGNRTKMGQKGSSGLF------RAVSAFGVVGFV 99

  Fly    69 HLLSCDYLLVATHRLFVGVLNGAVVWRLAGYDIIPYIPNSFQR---KENENYLRLLRQTLDTKFF 130
            ..|...|:::.|.|..:..:.|..::::...::| ||||...|   .:...|||:.:....:..|
Human   100 RFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMI-YIPNDSVRVTHPDEARYLRIFQNVDLSSNF 163

  Fly   131 YFSYRYDLTNSLQ------------RQREVAQSRPE-----------------VSGLLQRAEQRF 166
            ||||.|||::|||            .:.|:.|:|.|                 |.|:......::
Human   164 YFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQNRQESFDIFEDEGLITQGGSGVFGICSEPYMKY 228

  Fly   167 VWNGYVLRQFNCDKMEKFQLPLVLGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQG 231
            ||||.:|..........:.|.::.||...:::.|.|:..:.::|.|||.:.||||...||::.:|
Human   229 VWNGELLDIIKSTVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEG 293

  Fly   232 HVANFVETEQI------VEFN-GQLTGFVQTRGSMPFHWHQ-LPNLRYKPRPVLVPGKD---HLA 285
            .|||.||||||      :.|. |..:.:||.|||:|.:|.| :..:..|| |:.:...|   |:|
Human   294 DVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVPLYWSQDISTMMPKP-PITLDQADPFAHVA 357

  Fly   286 ACGLHFKEQIRLYGNNVAV-NLV------DHKGAEGELEATYARLVREMGNPQ--VRYESFDF-- 339
            |  |||.:..:.:|:.:.: |||      .|:....|........:.:...|:  :.|..:|.
Human   358 A--LHFDQMFQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAK 420

  Fly   340 ---HSECRKMRWDRLNILIDRLAHEQDQF---------------------GVYHVFDDGKLVSTQ 380
               ...|..:  ||||::.:.:..:...|                     |.  |...|:|   |
Human   421 YTKSKLCNVL--DRLNVIAESVVKKTGFFVNRPDSYCSILRPDEKWNELGGC--VIPTGRL---Q 478

  Fly   381 TGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQKLGVLHVGQKVEHASDIFESIFKGVWADNADLV 445
            ||:.||||:|||||||..|.|:.:.:|...|..||::. ...::..:|... :|:.::.|:.|.:
Human   479 TGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLID-KPNLQFDTDAVR-LFEELYEDHGDTL 541

  Fly   446 SLQYSGT---CALKTDFTRTGKRTKSGAMQDGKNSLMRYYLNNFADGQRQDSIDLFLGKYLVNDN 507
            ||||.|:   ..:|| :.:....|:..  :|...:|.|||.|.|:|..|||||:||||.:
Human   542 SLQYGGSQLVHRVKT-YRKIAPWTQHS--KDIMQTLSRYYSNAFSDADRQDSINLFLGVF----- 598

  Fly   508 EGGAVPSPLESK-HGWRFFTFPSVLLVAVAMFMITMTYPAEF-----NTENLL-----FMLFW 559
                  .|.|.| |.|..                    |.:|     ||..||     :..:|
Human   599 ------HPTEGKPHLWEL--------------------PTDFYLHHKNTMRLLPTRRSYTYWW 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sac1	NP_001189016.1	COG5329	3..566	CDD:227637	178/648 (27%)
		Syja_N	62..344	CDD:280532	93/340 (27%)
FIG4	NP_055660.1	COG5329	14..636	CDD:227637	178/648 (27%)
		Syja_N	93..423	CDD:280532	93/333 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	707..788

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5329
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820