DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sac1 and SYNJ1

DIOPT Version :9

Sequence 1:	NP_001189016.1	Gene:	Sac1 / 38137	FlyBaseID:	FBgn0283500	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_003886.3	Gene:	SYNJ1 / 8867	HGNCID:	11503	Length:	1612	Species:	Homo sapiens

Alignment Length:	550	Identity:	156/550 - (28%)
Similarity:	252/550 - (45%)	Gaps:	96/550 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SREENAVYDDMNLYIA------------PQSFIIEPNGGDELLVIGRHDKVTRVQPASGGLVANL 55
            ||.:.|..::..:..:            |.|.|:|....:|.|:.            ..|.||.|
Human    28 SRRKRAASEERRMAFSKGFRIYHKLDPPPFSLIVETRHKEECLMF------------ESGAVAVL 80

  Fly    56 RPTRR------------ICGVLGTIHLLSCD----YLLVATHRLFVGVLNGAVVWRLAGYDIIPY 104
            ....:            ..|:||.:.|...|    ||::.|..:.||.:..:.|:|:...:.|..
Human    81 SSAEKEAIKGTYSKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISL 145

  Fly   105 IPNSFQRKENENYLRLLRQTLDTKFFYFSYR---YDLTNSLQRQREVAQSRPEVSGLLQRAEQRF 166
            ..:|    .:|:.:..:|:.|::..|||::.   ..|..||...|.:.:         |..:.||
Human   146 RIDS----SDEDRISEVRKVLNSGNFYFAWSASGISLDLSLNAHRSMQE---------QTTDNRF 197

  Fly   167 VWNGYV---LRQF--NCDKMEKFQLPLVLGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRG 226
            .||..:   |:.:  |||   .:.|.|:.|.|.|..:....:.....:|:|.|.:|||||...||
Human   198 FWNQSLHLHLKHYGVNCD---DWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRG 259

  Fly   227 SDEQGHVANFVETEQIVEFNGQLTGFVQTRGSMPFHWHQLPNLRYKPRPVLV--------PGKDH 283
            :::.|||||||||||:|..:..::.|:|.|||:|..|.| |.|:.....|.:        |..|.
Human   260 TNDDGHVANFVETEQVVYLDDSVSSFIQIRGSVPLFWEQ-PGLQVGSHRVRMSRGFEANAPAFDR 323

  Fly   284 LAACGLHFKEQIRLYGNNVAVNLVDHKGAEGEL-EATYARLVREMGNPQVRYESFDFHSECRKMR 347
                  ||:....|||..:.|||:..|..|..| :|..:.|........::..:||:|...:..:
Human   324 ------HFRTLKNLYGKQIIVNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGK 382

  Fly   348 WDRLNILIDRLAHEQDQFGVYHVFDDGKLVSTQTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQ 412
            .::|:.::.....:...:|.:: |:..::...|:|..||||:|||||||.||:.|....|...|:
Human   383 AEKLHSVLKPQVQKFLDYGFFY-FNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLE 446

  Fly   413 KLGVLHVGQKVEHASDIFESIFKGVWADNADLVSLQYSGTCALKTDFTRTGKRTKSGAMQDGKNS 477
            .||:....|.|..    |:.:|:.:|:.|.|.:|..|:||.||:      ||    ..::||..|
Human   447 ALGLAEKPQLVTR----FQEVFRSMWSVNGDSISKIYAGTGALE------GK----AKLKDGARS 497

  Fly   478 LMRYYLNNFADGQRQDSID-LFLGKYLVND 506
            :.|...|||.|..:|::|| |.||..|.:|
Human   498 VTRTIQNNFFDSSKQEAIDVLLLGNTLNSD 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sac1	NP_001189016.1	COG5329	3..566	CDD:227637	155/549 (28%)
Sac1	NP_001189016.1	Syja_N	62..344	CDD:280532	89/302 (29%)
SYNJ1	NP_003886.3	Syja_N	99..379	CDD:280532	89/302 (29%)
		INPP5c_Synj1	572..907	CDD:197332
		DUF1866	906..1047	CDD:286093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920