DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sac1 and Synj1

DIOPT Version :9

Sequence 1:	NP_001189016.1	Gene:	Sac1 / 38137	FlyBaseID:	FBgn0283500	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_038944618.1	Gene:	Synj1 / 85238	RGDID:	69434	Length:	1609	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	157/550 - (28%)
Similarity:	252/550 - (45%)	Gaps:	93/550 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SREENAVYDDMNLYIA------------PQSFIIEPNGGDELLVIGRHDKVTRVQPASGGLVANL 55
            ||.:.|..::..:..:            |.|.|:|....:|.|:.            ..|.||.|
  Rat    29 SRRKRAASEERRMAFSKGFRIYHKLDPPPFSLIVETRHKEECLMF------------ESGAVAVL 81

  Fly    56 RPTRR------------ICGVLGTIHLLSCD----YLLVATHRLFVGVLNGAVVWRLAGYDIIPY 104
            ....:            ..|:||.:.|...|    ||::.|..:.||.:..:.|:|:...:.|..
  Rat    82 SSAEKEAIKGTYAKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISL 146

  Fly   105 IPNSFQRKENENYLRLLRQTLDTKFFYFSYR---YDLTNSLQRQREVAQSRPEVSGLLQRAEQRF 166
            ..::    .:|:.:..:|:.|::..|||::.   ..|..||...|.:.:         ...:.||
  Rat   147 RVDA----SDEDRISEVRKVLNSGNFYFAWSASGVSLDLSLNAHRSMQE---------HTTDNRF 198

  Fly   167 VWNGYV---LRQF--NCDKMEKFQLPLVLGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRG 226
            .||..:   |:.:  |||   .:.|.|:.|.|.|..:....:.....:|:|.|.:|||||...||
  Rat   199 FWNQSLHLHLKHYGVNCD---DWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRG 260

  Fly   227 SDEQGHVANFVETEQIVEFNGQLTGFVQTRGSMPFHWHQLPNLRYKPRPVLV--------PGKDH 283
            :::.|||||||||||::..:..::.|:|.|||:|..|.| |.|:.....|.:        |..|.
  Rat   261 TNDDGHVANFVETEQVIYLDDCVSSFIQIRGSVPLFWEQ-PGLQVGSHRVRMSRGFEANAPAFDR 324

  Fly   284 LAACGLHFKEQIRLYGNNVAVNLVDHKGAEGEL-EATYARLVREMGNPQVRYESFDFHSECRKMR 347
                  ||:....|||..:.|||:..|..|..| :|..:.|........:...|||:|...:..:
  Rat   325 ------HFRTLKDLYGKQIVVNLLGSKEGEHMLSKAFQSHLKASEHASDIHMVSFDYHQMVKGGK 383

  Fly   348 WDRLNILIDRLAHEQDQFGVYHVFDDGKLVSTQTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQ 412
            .::|:.::.....:...:|.:: ||...:...|:|..||||:|||||||.||:.|....|...|:
  Rat   384 AEKLHSVLKPQVQKFLDYGFFY-FDGSAVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLE 447

  Fly   413 KLGVLHVGQKVEHASDIFESIFKGVWADNADLVSLQYSGTCALKTDFTRTGKRTKSGAMQDGKNS 477
            .||:....|.|..    |:.:|:.:|:.|.|.:|..|:||.||:      || .|:|.::||..|
  Rat   448 ALGLAEKPQLVTR----FQEVFRSMWSVNGDSISKIYAGTGALE------GK-AKAGKLKDGARS 501

  Fly   478 LMRYYLNNFADGQRQDSID-LFLGKYLVND 506
            :.|...|||.|..:|::|| |.||..|.:|
  Rat   502 VTRTIQNNFFDSSKQEAIDVLLLGNTLNSD 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sac1	NP_001189016.1	COG5329	3..566	CDD:227637	156/549 (28%)
Sac1	NP_001189016.1	Syja_N	62..344	CDD:280532	87/302 (29%)
Synj1	XP_038944618.1	COG5329	100..523	CDD:227637	139/457 (30%)
		INPP5c_Synj1	576..911	CDD:197332
		RRM_SF	910..1052	CDD:418427
		PHA03247	<1097..1498	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920