DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sac1 and synj1

DIOPT Version :9

Sequence 1:	NP_001189016.1	Gene:	Sac1 / 38137	FlyBaseID:	FBgn0283500	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_005155414.1	Gene:	synj1 / 337236	ZFINID:	ZDB-GENE-030131-9180	Length:	1612	Species:	Danio rerio

Alignment Length:	520	Identity:	155/520 - (29%)
Similarity:	247/520 - (47%)	Gaps:	75/520 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PQSFIIEPNGGDELLVIGRHDKVTRVQPASGGLVANLRPTRR------------ICGVLGTIHLL 71
            |.|.|:|....:|.|:.            ..|.||.|....:            ..|:||.:.|.
Zfish    17 PYSVIVETRNREECLMF------------ESGAVAVLSAAEKETIKASYTKMLDAYGILGVLRLN 69

  Fly    72 SCDYLL----VATHRLFVGVLNGAVVWRLAGYDIIPYIPNSFQRKENENYLRLLRQTLDTKFFYF 132
            ..|.:|    |.|....||.:..:.|:|:.|.|.:. :.|.   ..:|:.:..:|:.|::..|||
Zfish    70 LGDSMLHSLVVVTGCSSVGKVQDSEVFRVTGTDFVS-LKND---PTDEDRIADVRKVLNSGNFYF 130

  Fly   133 SYR---YDLTNSLQRQREVAQSRPEVSGLLQRAEQRFVWNGYV---LRQF--NCDKMEKFQLPLV 189
            ::.   ..|..||...|.:.:         ..::.||.||..:   |:.:  |||   .:.|.|:
Zfish   131 AWSSTGVSLDLSLNAHRRIRE---------DTSDNRFFWNQSLHLHLKHYGVNCD---DWLLRLM 183

  Fly   190 LGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQIVEFNGQLTGFVQ 254
            .|.|.|..:....:.....:|:|.|.:|||||...||:::.|.||||||||||:..:.:::.|:|
Zfish   184 CGGVEIRTIYAGHKQAKACVISRLSSERAGTRFNVRGTNDDGQVANFVETEQIIFLDDKVSSFIQ 248

  Fly   255 TRGSMPFHWHQLPNLRY-KPRPVLVPG-KDHLAACGLHFKEQIRLYGNNVAVNLVDHKGAEGEL- 316
            .|||:|..|.| |.::. ..|..|..| :.:..|...||....||||..:.:||:..|..|..|
Zfish   249 IRGSIPLFWEQ-PGIQVGSHRVKLSRGFEANAPAFERHFSALKRLYGKQLIINLLGMKEGEHMLS 312

  Fly   317 EATYARLVREMGNPQVRYESFDFHSECRKMRWDRLNIL----IDRLAHEQDQFGVYHVFDDGKLV 377
            :|..:.|.....:..|:..:||:|...:..:.::|..:    |.:...:.|.|  |:..:.| :.
Zfish   313 KAFQSHLKASEHSNAVKMLNFDYHQMVKGGKTEKLQTVLKPQISKFVEDCDFF--YYSGETG-IQ 374

  Fly   378 STQTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQKLGVLHVGQKVEHASDIFESIFKGVWADNA 442
            ..|:|..|:||:|||||||.||:.:|...|...|:.:|:....|.|..    |:.:|:.:|:.|.
Zfish   375 RCQSGTIRSNCLDCLDRTNSVQAFIALEMLPKQLEAMGLTEKPQLVAR----FQEVFRSMWSTNG 435

  Fly   443 DLVSLQYSGTCALKTDFTRTGKRTKSGAMQDGKNSLMRYYLNNFADGQRQDSIDLF-LGKYLVND 506
            |.:|..|:||.||      .|| .|.|.::||..|:.|...|||.|..:|::||:. ||..|.:|
Zfish   436 DSISKIYAGTGAL------DGK-AKGGKLKDGARSVTRTIQNNFFDSSKQEAIDILRLGSTLNSD 493

Fly 507 506
Zfish 494 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sac1	NP_001189016.1	COG5329	3..566	CDD:227637	155/520 (30%)
Sac1	NP_001189016.1	Syja_N	62..344	CDD:280532	89/296 (30%)
synj1	XP_005155414.1	Syja_N	60..340	CDD:280532	89/296 (30%)
		INPP5c_Synj1	538..873	CDD:197332
		RRM_SF	872..1010	CDD:302621
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920