DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sac1 and Synj2

DIOPT Version :9

Sequence 1:	NP_001189016.1	Gene:	Sac1 / 38137	FlyBaseID:	FBgn0283500	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001106824.1	Gene:	Synj2 / 20975	MGIID:	1201671	Length:	1479	Species:	Mus musculus

Alignment Length:	564	Identity:	164/564 - (29%)
Similarity:	249/564 - (44%)	Gaps:	129/564 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PQSFIIEPNG-GDELLVIGRHDKVTRVQPASGGLVANLRPTRR------------ICGVLGTIHL 70
            |.|.::|..| ||.||.             ..|.||.|.|..:            ..|.||.:.|
Mouse    18 PSSVLLEARGRGDCLLF-------------EAGAVATLAPEEKEVIKGLYSKLTDAYGCLGELRL 69

  Fly    71 LS----CDYLLVATHRLFVGVLNGAVVWRLAGYDIIPYIPNSFQRKENENYLRLLRQTLDTKFFY 131
            .|    ..:|::.|..:.||.:..|.::::...::.|.    .:..:.|:.|..|::.|.:..||
Mouse    70 QSGGVPLSFLVLVTGCMSVGRIPDAEIYKITATELYPL----QEEAKEEDRLPTLKKILSSGVFY 130

  Fly   132 FSYR-----YDLTNSLQRQREVAQSRPEVSGLLQRAE--QRFVWNGYV---LR--QFNCDKMEKF 184
            |::.     :|||...|:|.:            ..:|  ..|.||..:   ||  |.||   ..:
Mouse   131 FAWPNDGACFDLTIRAQKQGD------------DGSEWGTSFFWNQLLHVPLRQHQVNC---HNW 180

  Fly   185 QLPLVLGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQIVEFNGQL 249
            .|.::.|.|:|..|..:.:.....:|:|.|.:|||.|...||.::.|||:|||||||.:..:..:
Mouse   181 LLKVICGVVTIRTVYASHKQAKACLISRISCERAGARFLTRGVNDDGHVSNFVETEQTIYMDDGV 245

  Fly   250 TGFVQTRGSMPFHWHQLPNLRYKPRPVLVPGKDHLAACGLH----------------FKEQIRLY 298
            :.|||.|||:|..|.|         |.|..|..||.   ||                .|||   |
Mouse   246 SSFVQIRGSVPLFWEQ---------PGLQVGSHHLR---LHRGLEANAPAFERHMVLLKEQ---Y 295

  Fly   299 GNNVAVNLVDHKGAEGELEATYARLV----REMGNPQVRYESFDFHSECRKMRWDRL-NILIDRL 358
            |..|.|||:..:|.|..|...:.:|:    .....|.:   :||||...:..:.::| |:|..:|
Mouse   296 GKQVVVNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMI---NFDFHQFAKGRKLEKLENLLRPQL 357

  Fly   359 AHEQDQFGVYHVFDDGKLVST--QTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQKLGVLHVGQ 421
            ....:.||   ||..|:.||.  |.|..|.||:|||||||.||..:|...|...|:.||:
Mouse   358 QLHWEDFG---VFAKGENVSPRFQKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGL----- 414

  Fly   422 KVEHASDIFESIFKGVWADNADLVSLQYSGTCALKTDFTRTGKRTKSGAMQDGKNSLMRYYLNNF 486
            ..:...|.|...||.:|:.|...:|..::|:.||:      || .|.|.::||..|:.|...:||
Mouse   415 NSKPIIDRFVESFKAMWSLNGHSLSKVFTGSRALE------GK-AKVGKLKDGARSMSRTIQSNF 472

  Fly   487 ADGQRQDSIDLFL------------GKYLVNDNEGGAVPSPLES 518
            .||.:|::|.|.|            |:.|:::....|.|..|::
Mouse   473 FDGVKQEAIKLLLVGDVYNEESTDKGRMLLDNTALLATPRILKA 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sac1	NP_001189016.1	COG5329	3..566	CDD:227637	164/564 (29%)
Sac1	NP_001189016.1	Syja_N	62..344	CDD:280532	90/317 (28%)
Synj2	NP_001106824.1	Syja_N	61..342	CDD:280532	90/317 (28%)
		EEP	530..861	CDD:294334
		DUF1866	872..1008	CDD:286093
		CEND1	1290..>1405	CDD:292305
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920