DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sac1 and unc-26

DIOPT Version :9

Sequence 1:	NP_001189016.1	Gene:	Sac1 / 38137	FlyBaseID:	FBgn0283500	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001023266.1	Gene:	unc-26 / 178284	WormBaseID:	WBGene00006763	Length:	1119	Species:	Caenorhabditis elegans

Alignment Length:	516	Identity:	155/516 - (30%)
Similarity:	238/516 - (46%)	Gaps:	95/516 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SFIIEPNGGDELLVIGRHDKVTRVQPASGGLVANL---------RPTRRIC---GVLGTIHLLSC 73
            |.::|.||.|..|:.            .||.:|.|         |..::|.   |:||.:.:...
Worm    19 SILVEKNGLDGSLLF------------QGGAIATLDSDSTDVERRSYQKIVDAYGILGVLAITKD 71

  Fly    74 DYLLVA-THRLFVGVLNGAVVWRLAGYDIIPYIPNSFQRKEN-ENYLRLLRQTLDTKFFYFS--Y 134
            :.:||| |..|.||.|.||.:.::...:.|..  .:|...|| ::.:..|::.|.::.||||  .
Worm    72 EAVLVAVTGVLSVGQLYGADILKITNVEFISL--RTFGSVENVDSRIIDLQRLLSSQMFYFSSLQ 134

  Fly   135 RYDLTNSLQRQREVAQSRPEVSGLLQRAEQRFVWN---GYVLRQFNCDKMEKFQLPLVLGFVSIN 196
            .||||.|.|.:.....|           :.||.||   .:..:::..| .:.:.|..:.|.|.:.
Worm   135 SYDLTRSAQHRDSHDCS-----------DARFFWNRSLHFSFQRYGID-TDNWLLKCMAGSVLVR 187

  Fly   197 QVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQIVEFNGQLTGFVQTRGSMPF 261
            .|.:...|...::|:|.|.:|.|||...||::..|:|||||||||::.|:.:....:|.|||:|.
Worm   188 VVYVGANTGRVALISRLSCERVGTRFNVRGANYLGNVANFVETEQLLLFDEKECSLLQIRGSIPL 252

  Fly   262 HWHQLPNLRYKPRPV-LVPGKDHLAACGLHFKEQIRLYGNNVAVNLVDHKGAEGELEATYARLVR 325
            .|.| |.:......| |...:..|.|...|..:....||....|||:..|  |||         |
Worm   253 FWEQ-PGVNVGSHKVKLRAFETSLPAYHRHLSQLQHRYGEFAIVNLLGRK--EGE---------R 305

  Fly   326 EMGN------------PQVRYESFDFHSECRKMRWDRLNILIDRLAHEQDQFGVYHVFDDGK-LV 377
            .:|:            |.|.:..||:|:: .|:..:.:..|..:::....:.|.:  :..|| :|
Worm   306 VLGDAFKTQHKSSHFAPLVDFIDFDYHAQ-MKISKEAIVQLKKKMSPHMTKHGFF--YSMGKEIV 367

  Fly   378 STQTGVFRTNCIDCLDRTNVVQS----MLARRSLTAVLQKLGVLHVGQKVEHASDIFESIFKGVW 438
            ..||||.||||:|||||||.||:    .::...:..:....|.::|.|:|       |.|.:.:|
Worm   368 KRQTGVIRTNCLDCLDRTNAVQTAIGLQMSHDQVAFLNLNAGKVNVEQRV-------EEILRDLW 425

  Fly   439 ADNADLVSLQYSGTCALKTDFTRTGKRTKSGAMQDGKNSLMRYYLNNFADGQRQDSIDLFL 499
            ..|.|..|..|:||.||      .||    ..::|...||.|...||..||.:|:|.||||
Worm   426 QKNGDQCSTIYAGTGAL------DGK----SKLKDASRSLARTIQNNLMDGAKQESFDLFL 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sac1	NP_001189016.1	COG5329	3..566	CDD:227637	155/516 (30%)
Sac1	NP_001189016.1	Syja_N	62..344	CDD:280532	89/304 (29%)
unc-26	NP_001023266.1	Syja_N	60..336	CDD:280532	89/302 (29%)
		INPP5c_Synj	527..835	CDD:197323
		RRM_SF	850..978	CDD:302621
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920