DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sac1 and Sacm1l

DIOPT Version :9

Sequence 1:	NP_001189016.1	Gene:	Sac1 / 38137	FlyBaseID:	FBgn0283500	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001344426.1	Gene:	Sacm1l / 116482	RGDID:	69223	Length:	609	Species:	Rattus norvegicus

Alignment Length:	587	Identity:	278/587 - (47%)
Similarity:	389/587 - (66%)	Gaps:	25/587 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 YDDMNLYIAPQSFIIE--PNGGDELLVIGRHDKV-TRVQPASGGLVANLRPTRRICGVLGTIHLL 71
            |:.:.|:|.|:.|.:|  .:|.|::|:|   |:| |.|..|....|.....||.|.|::|||||:
  Rat     6 YEHLKLHITPEKFYVEACDDGADDVLII---DRVSTEVTLAVKKDVPPSAVTRPIYGIMGTIHLV 67

  Fly    72 SCDYLLVATHRLFVGVLNGAVVWRLAGYDIIPYIP-----NSFQRKENENYLRLLRQTLDTKFFY 131
            :.:||:|.|.::.||.....|:|:...:|::.|..     ...|.::|:.:|.:|...|.|..||
  Rat    68 AGNYLVVITKKMKVGEFFNHVIWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLSTDGFY 132

  Fly   132 FSYRYDLTNSLQRQREVAQSRPEVSGLLQRAEQRFVWNGYVLRQFNCD-KMEKFQLPLVLGFVSI 195
            ||..||||::|||....:....|:| ||:||:|||||||::||:.:.. ::.:|.||::.||:::
  Rat   133 FSTTYDLTHTLQRLSNTSPEFQEMS-LLERADQRFVWNGHLLRELSAQPEVHRFALPVLHGFITM 196

  Fly   196 NQVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQIVEFNGQLTGFVQTRGSMP 260
            :...|||:.|.|.:|:|||..|||.|.:.||.|.:||.||||||||||.::|....|||||||:|
  Rat   197 HSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYSGNRASFVQTRGSIP 261

  Fly   261 FHWHQLPNLRYKPRPVLVPGKDHLAACGLHFKEQIRLYGNNVAVNLVDHKGAEGELEATYARLVR 325
            ..|.|.|||:|||.|.:....:|:.....||..|:.:||..|.:|||:|||:|..||.|:|::|.
  Rat   262 VFWSQRPNLKYKPDPQINKVANHMDGFQRHFDSQVIIYGKQVIINLVNHKGSEKPLEQTFAKMVS 326

  Fly   326 EMGNPQVRYESFDFHSECRKMRWDRLNILIDRLAHEQDQFGVYHVFDDGKLVSTQTGVFRTNCID 390
            .:|:..:||.:||||.||:.||||||:||:|::|..||:...:.|...||:|:.|.||||:||:|
  Rat   327 SLGSGMIRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYFLVDSAGKVVTNQEGVFRSNCMD 391

  Fly   391 CLDRTNVVQSMLARRSLTAVLQKLGVLHVGQKVEHASDIFESIFKGVWADNADLVSLQYSGTCAL 455
            |||||||:||:||||||.|.||:|||||||||:|. .|.||.|:|..|||||:..:.||:||.||
  Rat   392 CLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEE-QDEFEKIYKNAWADNANACAKQYAGTGAL 455

  Fly   456 KTDFTRTGKRTKSGAMQDGKNSLMRYYLNNFADGQRQDSIDLFLGKYLVNDNEGGAVPSPLESKH 520
            |||||||||||:.|.:.||.|||:|||.|||:||.||||||||||.|.|::.:.   .|||....
  Rat   456 KTDFTRTGKRTQLGLVMDGFNSLLRYYKNNFSDGFRQDSIDLFLGNYSVDELDS---HSPLSVPR 517

  Fly   521 GWRFFTFPSVLLVAVAMFMITMTYPAEFNTENLLFMLFWGAMIAVSATG----ILHYGVEFVQWP 581
            .|:|...|.:::||.:|.:|.:....:..||.|.::||||    |::.|    ||:.|.:||..|
  Rat   518 DWKFLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWG----VASIGTFFIILYNGKDFVDAP 578

  Fly   582 RL 583
            ||
  Rat   579 RL 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sac1	NP_001189016.1	COG5329	3..566	CDD:227637	268/564 (48%)
Sac1	NP_001189016.1	Syja_N	62..344	CDD:280532	126/287 (44%)
Sacm1l	NP_001344426.1	COG5329	57..513	CDD:227637	234/460 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352472
Domainoid	1	1.000	263	1.000	Domainoid score	I1863
eggNOG	1	0.900	-	-		E1_COG5329
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6320
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1183
OMA	1	1.010	-	-		QHG55111
OrthoDB	1	1.010	-	-		D153624at33208
OrthoFinder	1	1.000	-	-		FOG0002973
OrthoInspector	1	1.000	-	-		oto96050
orthoMCL	1	0.900	-	-		OOG6_101364
Panther	1	1.100	-	-	LDO	PTHR45662
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1717
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770