DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sac1 and Synj1

DIOPT Version :9

Sequence 1:	NP_001189016.1	Gene:	Sac1 / 38137	FlyBaseID:	FBgn0283500	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_011244377.1	Gene:	Synj1 / 104015	MGIID:	1354961	Length:	1714	Species:	Mus musculus

Alignment Length:	550	Identity:	157/550 - (28%)
Similarity:	253/550 - (46%)	Gaps:	93/550 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SREENAVYDDMNLYIA------------PQSFIIEPNGGDELLVIGRHDKVTRVQPASGGLVANL 55
            ||.:.|..::..:..:            |.|.|:|....:|.|:.            ..|.||.|
Mouse   133 SRRKRAASEERRMAFSKGFRIYHKLDPPPFSLIVETRHKEECLMF------------ESGAVAVL 185

  Fly    56 RPTRR------------ICGVLGTIHLLSCD----YLLVATHRLFVGVLNGAVVWRLAGYDIIPY 104
            ....:            ..|:||.:.|...|    ||::.|..:.||.:..:.|:|:...:.|..
Mouse   186 SSAEKEAIKGTYAKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISL 250

  Fly   105 IPNSFQRKENENYLRLLRQTLDTKFFYFSYR---YDLTNSLQRQREVAQSRPEVSGLLQRAEQRF 166
            ..::    .:|:.:..:|:.|::..|||::.   ..|..||...|.:.:         ...:.||
Mouse   251 RVDA----SDEDRISEVRKVLNSGNFYFAWSASGVSLDLSLNAHRSMQE---------HTTDNRF 302

  Fly   167 VWNGYV---LRQF--NCDKMEKFQLPLVLGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRG 226
            .||..:   |:.:  |||   .:.|.|:.|.|.|..:....:.....:|:|.|.:|||||...||
Mouse   303 FWNQSLHLHLKHYGVNCD---DWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRG 364

  Fly   227 SDEQGHVANFVETEQIVEFNGQLTGFVQTRGSMPFHWHQLPNLRYKPRPVLV--------PGKDH 283
            :::.|||||||||||::..:..::.|:|.|||:|..|.| |.|:.....|.:        |..|.
Mouse   365 TNDDGHVANFVETEQVIYLDDCVSSFIQIRGSVPLFWEQ-PGLQVGSHRVRMSRGFEANAPAFDR 428

  Fly   284 LAACGLHFKEQIRLYGNNVAVNLVDHKGAEGEL-EATYARLVREMGNPQVRYESFDFHSECRKMR 347
                  ||:....|||..:.|||:..|..|..| :|..:.|........:...|||:|...:..:
Mouse   429 ------HFRTLKDLYGKQIVVNLLGSKEGEHMLSKAFQSHLKASEHASDIHMVSFDYHQMVKGGK 487

  Fly   348 WDRLNILIDRLAHEQDQFGVYHVFDDGKLVSTQTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQ 412
            .::|:.::.....:...:|.:: ||..::...|:|..||||:|||||||.||:.|....|...|:
Mouse   488 AEKLHSILKPQVQKFLDYGFFY-FDGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLE 551

  Fly   413 KLGVLHVGQKVEHASDIFESIFKGVWADNADLVSLQYSGTCALKTDFTRTGKRTKSGAMQDGKNS 477
            .||:....|.|..    |:.:|:.:|:.|.|.:|..|:||.||:      || .|:|.::||..|
Mouse   552 ALGLAEKPQLVTR----FQEVFRSMWSVNGDSISKIYAGTGALE------GK-AKAGKLKDGARS 605

  Fly   478 LMRYYLNNFADGQRQDSID-LFLGKYLVND 506
            :.|...|||.|..:|::|| |.||..|.:|
Mouse   606 VTRTIQNNFFDSSKQEAIDVLLLGNTLNSD 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sac1	NP_001189016.1	COG5329	3..566	CDD:227637	156/549 (28%)
Sac1	NP_001189016.1	Syja_N	62..344	CDD:280532	87/302 (29%)
Synj1	XP_011244377.1	COG5329	204..627	CDD:227637	139/457 (30%)
		INPP5c_Synj1	680..1015	CDD:197332
		RRM_SF	1014..1155	CDD:388407
		PHA03247	<1207..1609	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920