DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sac1 and synj1

DIOPT Version :9

Sequence 1:	NP_001189016.1	Gene:	Sac1 / 38137	FlyBaseID:	FBgn0283500	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_004912203.1	Gene:	synj1 / 100487517	XenbaseID:	XB-GENE-956330	Length:	1548	Species:	Xenopus tropicalis

Alignment Length:	523	Identity:	157/523 - (30%)
Similarity:	241/523 - (46%)	Gaps:	82/523 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PQSFIIEPNGGDELLVIGRHDKVTRVQPASGGLVANLRPTRR------------ICGVLGTIHLL 71
            |.|.|:|....:|.|:.            ..|.||.|....:            ..|:||.:.|.
Frog    17 PFSVIVEARNREECLLF------------ESGAVAVLSSAEKEAIKNSYTKVMDAYGLLGVLRLN 69

  Fly    72 SCD----YLLVATHRLFVGVLNGAVVWRLAGYDIIPYIPNSFQRKENENYLRLLRQTLDTKFFYF 132
            ..|    ||::.|..:.||.:..:.|:|:...|.|....:...    |:.:..:|:.|::..|||
Frog    70 LGDSMSYYLVLVTGCMSVGKIQDSEVFRVTSTDFISLRMDPMA----EDRMSEVRKVLNSGSFYF 130

  Fly   133 SYR---YDLTNSLQRQREVAQSRPEVSGLLQRAEQRFVWNGYV---LRQF--NCDKMEKFQLPLV 189
            ::.   ..|..||...|...:         .|.:.||.||..:   |:.:  |||   ::.|.|:
Frog   131 AWSSTGVSLDLSLNAHRSTQE---------HRTDNRFFWNQSLHLHLKHYGVNCD---EWLLRLM 183

  Fly   190 LGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQIVEFNGQLTGFVQ 254
            .|.|.|..:....|.....||:|.|.:|||||...||:::.|..||||||||::..:..::.|:|
Frog   184 CGGVEIRTIYAGHQQAKACIISRLSCERAGTRFNVRGTNDYGQAANFVETEQVIYLDDCVSSFIQ 248

  Fly   255 TRGSMPFHWHQLPNLRYKPRPVLV--------PGKDHLAACGLHFKEQIRLYGNNVAVNLVDHKG 311
            .|||:|..|.| |.|:.....|.:        |..|.      ||....||||....|||:..|.
Frog   249 IRGSIPLFWEQ-PGLQVGSHRVRMSRGFEANAPAFDR------HFLTLKRLYGKQFIVNLLGSKE 306

  Fly   312 AEGELEATYA-RLVREMGNPQVRYESFDFHSECRKMRWDRL-NILIDRLAHEQDQFGVYHVFDDG 374
            .|..|...:. .|.....:..::..:||:|...|..:.::| ::|..::....::.|.:.: |..
Frog   307 GESMLSRAFQNHLKASEHSASIQMMNFDYHQMVRGGKAEKLHSVLKPKVNTFLEECGFFFL-DKN 370

  Fly   375 KLVSTQTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQKLGVLHVGQKVEHASDIFESIFKGVWA 439
            .:..||.|..|:||:|||||||.||:.|....|...|:.||:....|.|..    |:.:|:.:|:
Frog   371 GVHRTQIGTIRSNCLDCLDRTNSVQAFLGLEMLLKQLEVLGLAEKPQLVTR----FQEVFRSMWS 431

  Fly   440 DNADLVSLQYSGTCALKTDFTRTGKRTKSGAMQDGKNSLMRYYLNNFADGQRQDSID-LFLGKYL 503
            .|.|.:|..|:||.||:      || .|.|.::||..|:.|...|||.||.:|::|| |.||..|
Frog   432 TNGDSISKIYAGTGALE------GK-AKGGKLKDGARSVTRTIQNNFFDGSKQEAIDVLLLGNTL 489

  Fly   504 VND 506
            .:|
Frog   490 NSD 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sac1	NP_001189016.1	COG5329	3..566	CDD:227637	157/523 (30%)
Sac1	NP_001189016.1	Syja_N	62..344	CDD:280532	88/302 (29%)
synj1	XP_004912203.1	COG5329	9..484	CDD:227637	152/513 (30%)
		EEP	537..872	CDD:382041
		RRM_SF	871..987	CDD:388407
		PHA03247	<1061..1264	CDD:223021
		PHA03378	<1072..1483	CDD:223065
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920